PMID- 29288626
OWN - NLM
STAT- MEDLINE
DCOM- 20190109
LR  - 20190109
IS  - 1873-2968 (Electronic)
IS  - 0006-2952 (Linking)
VI  - 151
DP  - 2018 May
TI  - The P2X7 receptor: A main player in inflammation.
PG  - 234-244
LID - S0006-2952(17)30733-5 [pii]
LID - 10.1016/j.bcp.2017.12.021 [doi]
AB  - Damage associated molecular patterns (DAMPs) are intracellular molecules released 
      from infected or injured cells to activate inflammatory and reparatory responses. 
      One of the most ancient and conserved DAMPs is extracellular ATP that exerts its 
      phlogistic activity mainly through activation of the P2X7 receptor (P2X7R). The 
      P2X7R is an ATP gated ion channel, expressed by most immune cells, including the 
      monocyte-derived cell lineages, T and B lymphocytes and their precursors. Here we 
      give an overview of recent and established literature on the role of P2X7R in 
      septic and sterile inflammation. P2X7R ability in restraining intracellular 
      bacteria and parasite infection by modulation of the immune response are 
      described, with particular focus on Mycobacteria and Plasmodium. Emerging 
      literature on the role of P2X7 in viral infections such as HIV-1 is also briefly 
      covered. Finally, we describe the numerous intracellular pathways related to 
      inflammation and activated by the P2X7R, including the NLRP3 inflammasome, NF-kB, 
      NFAT, GSK3beta and VEGF, and discuss the involvement of P2X7R in chronic diseases. 
      The possible therapeutic applications of P2X7R antagonists are also described.
CI  - Copyright (c) 2017. Published by Elsevier Inc.
FAU - Adinolfi, Elena
AU  - Adinolfi E
AD  - Department of Morphology, Surgery and Experimental Medicine, Section of 
      Pathology, Oncology and Experimental Biology, University of Ferrara, Ferrara, 
      Italy.
FAU - Giuliani, Anna Lisa
AU  - Giuliani AL
AD  - Department of Morphology, Surgery and Experimental Medicine, Section of 
      Pathology, Oncology and Experimental Biology, University of Ferrara, Ferrara, 
      Italy.
FAU - De Marchi, Elena
AU  - De Marchi E
AD  - Department of Morphology, Surgery and Experimental Medicine, Section of 
      Pathology, Oncology and Experimental Biology, University of Ferrara, Ferrara, 
      Italy.
FAU - Pegoraro, Anna
AU  - Pegoraro A
AD  - Department of Morphology, Surgery and Experimental Medicine, Section of 
      Pathology, Oncology and Experimental Biology, University of Ferrara, Ferrara, 
      Italy.
FAU - Orioli, Elisa
AU  - Orioli E
AD  - Department of Morphology, Surgery and Experimental Medicine, Section of 
      Pathology, Oncology and Experimental Biology, University of Ferrara, Ferrara, 
      Italy.
FAU - Di Virgilio, Francesco
AU  - Di Virgilio F
AD  - Department of Morphology, Surgery and Experimental Medicine, Section of 
      Pathology, Oncology and Experimental Biology, University of Ferrara, Ferrara, 
      Italy. Electronic address: fdv@unife.it.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20171227
PL  - England
TA  - Biochem Pharmacol
JT  - Biochemical pharmacology
JID - 0101032
RN  - 0 (Inflammasomes)
RN  - 0 (Purinergic P2X Receptor Agonists)
RN  - 0 (Purinergic P2X Receptor Antagonists)
RN  - 0 (Receptors, Purinergic P2X7)
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/drug therapy/immunology/metabolism
MH  - Chronic Disease
MH  - Clinical Trials as Topic
MH  - Communicable Diseases/drug therapy/immunology/metabolism
MH  - Drug Evaluation, Preclinical
MH  - Humans
MH  - Inflammasomes/metabolism
MH  - Inflammation/*drug therapy/immunology/metabolism
MH  - Neoplasms/drug therapy/immunology/metabolism
MH  - Neurodegenerative Diseases/drug therapy/immunology/metabolism
MH  - Purinergic P2X Receptor Agonists/administration & dosage/adverse 
      effects/*therapeutic use
MH  - Purinergic P2X Receptor Antagonists/administration & dosage/adverse 
      effects/*therapeutic use
MH  - Receptors, Purinergic P2X7/*metabolism
OTO - NOTNLM
OT  - ATP
OT  - Immune response
OT  - Inflammation
OT  - P2X7
OT  - Pathogens
EDAT- 2017/12/31 06:00
MHDA- 2019/01/10 06:00
CRDT- 2017/12/31 06:00
PHST- 2017/11/20 00:00 [received]
PHST- 2017/12/22 00:00 [accepted]
PHST- 2017/12/31 06:00 [pubmed]
PHST- 2019/01/10 06:00 [medline]
PHST- 2017/12/31 06:00 [entrez]
AID - S0006-2952(17)30733-5 [pii]
AID - 10.1016/j.bcp.2017.12.021 [doi]
PST - ppublish
SO  - Biochem Pharmacol. 2018 May;151:234-244. doi: 10.1016/j.bcp.2017.12.021. Epub 
      2017 Dec 27.