PMID- 29288827 OWN - NLM STAT- MEDLINE DCOM- 20180903 LR - 20220316 IS - 1872-7573 (Electronic) IS - 0378-8741 (Linking) VI - 215 DP - 2018 Apr 6 TI - Antidepressant-like effects of water extract of Gastrodia elata Blume on neurotrophic regulation in a chronic social defeat stress model. PG - 132-139 LID - S0378-8741(17)33351-2 [pii] LID - 10.1016/j.jep.2017.12.044 [doi] AB - ETHNOPHARMACOLOGY RELEVANCE: Gastrodia elata Blume (GE) is a traditional Chinese medicine commonly used to treat dizziness, epilepsy, paralysis and some emotional symptoms in east Asia. We previously showed that the water extract of Gastrodia elata Blume (WGE) possesses anti-depression like effects in a forced swimming test and chronic mild stress model. AIM OF THE STUDY: The aim of this study was to investigate the antidepressant-like effects of WGE and potential mechanisms related to brain-derived neurotrophic factor (BDNF) regulation in mice exposed to chronic social defeat stress (CSDS) model. MATERIALS AND METHODS: Fifty C57BL/6 mice were divided into 5 groups as follows: a control (CTL) group, CSDS group, and 3 WGE groups receiving 250, 500 or 1000mg/kg body weight in the CSDS model. Mice were administered WGE for 24 days by oral gavage, and the social defeat stress paradigm began on day 14, except for the control group. A social interaction test was conducted to evaluate the antidepressant-like effects of WGE. Blood samples were collected to measure serum corticosterone levels, and the brain was dissected to investigate the expression of BDNF-related signaling pathway proteins using western blotting. RESULTS: Oral administration of WGE improved depression-like behaviors and stress-induced elevations of corticosterone. Further, WGE increased the protein expression of BDNF and promoted the hippocampal protein phosphorylation ratio of cAMP response element binding protein (CREB) and protein kinase B (Akt). CONCLUSION: WGE exerts antidepressant-like effects on mice in a CSDS model, likely through activating of the BDNF/CREB/Akt pathway. Therefore, WGE has potential as a supplement or an adjuvant to prevent or treat clinical depressive disorders. CI - Copyright (c) 2018 Elsevier B.V. All rights reserved. FAU - Lin, Yu-En AU - Lin YE AD - Institute of Food Science and Technology, National Taiwan University, Taipei 10617, Taiwan, ROC. Electronic address: moon7993@hotmail.com. FAU - Chou, Shao-Ting AU - Chou ST AD - Institute of Food Science and Technology, National Taiwan University, Taipei 10617, Taiwan, ROC. Electronic address: silly7995@hotmail.com. FAU - Lin, Shih-Hang AU - Lin SH AD - Institute of Food Science and Technology, National Taiwan University, Taipei 10617, Taiwan, ROC. Electronic address: d01641006@ntu.edu.tw. FAU - Lu, Kuan-Hung AU - Lu KH AD - Institute of Food Science and Technology, National Taiwan University, Taipei 10617, Taiwan, ROC. Electronic address: a062016@gmail.com. FAU - Panyod, Suraphan AU - Panyod S AD - Institute of Food Science and Technology, National Taiwan University, Taipei 10617, Taiwan, ROC. Electronic address: s.panyod@hotmail.com. FAU - Lai, Yi-Syuan AU - Lai YS AD - Department of Hospitality Management, Yu Da University of Science and Technology, Miaoli 36143, Taiwan, ROC. Electronic address: milkway-star@hotmail.com. FAU - Ho, Chi-Tang AU - Ho CT AD - Department of Food Science, Rutgers University, New Brunswick, NJ 08901-8520, USA. Electronic address: hochitang@gmail.com. FAU - Sheen, Lee-Yan AU - Sheen LY AD - Institute of Food Science and Technology, National Taiwan University, Taipei 10617, Taiwan, ROC; Center for Food and Biomolecules, National Taiwan University, Taipei 10617, Taiwan, ROC. Electronic address: lysheen@ntu.edu.tw. LA - eng PT - Journal Article DEP - 20171227 PL - Ireland TA - J Ethnopharmacol JT - Journal of ethnopharmacology JID - 7903310 RN - 0 (Antidepressive Agents) RN - 0 (Plant Extracts) RN - 059QF0KO0R (Water) RN - W980KJ009P (Corticosterone) SB - IM MH - Animals MH - Antidepressive Agents/chemistry/*pharmacology MH - Behavior, Animal/*drug effects MH - Body Weight MH - Corticosterone/blood MH - Depression/drug therapy MH - Gastrodia/*chemistry MH - Male MH - Mice MH - Mice, Inbred C57BL MH - Plant Extracts/chemistry/*pharmacology MH - *Stress, Psychological MH - Water OTO - NOTNLM OT - Antidepressant activity OT - BDNF/CREB/Akt OT - Brain-derived neurotrophic factor OT - Chronic social defeat stress model OT - Gastrodia elata Blume EDAT- 2017/12/31 06:00 MHDA- 2018/09/04 06:00 CRDT- 2017/12/31 06:00 PHST- 2017/09/08 00:00 [received] PHST- 2017/10/31 00:00 [revised] PHST- 2017/12/26 00:00 [accepted] PHST- 2017/12/31 06:00 [pubmed] PHST- 2018/09/04 06:00 [medline] PHST- 2017/12/31 06:00 [entrez] AID - S0378-8741(17)33351-2 [pii] AID - 10.1016/j.jep.2017.12.044 [doi] PST - ppublish SO - J Ethnopharmacol. 2018 Apr 6;215:132-139. doi: 10.1016/j.jep.2017.12.044. Epub 2017 Dec 27.