PMID- 29288952 OWN - NLM STAT- MEDLINE DCOM- 20190627 LR - 20190627 IS - 1879-1379 (Electronic) IS - 0022-3956 (Linking) VI - 98 DP - 2018 Mar TI - Effects of the brain-derived neurotropic factor variant Val66Met on cortical structure in late childhood and early adolescence. PG - 51-58 LID - S0022-3956(17)30759-8 [pii] LID - 10.1016/j.jpsychires.2017.12.008 [doi] AB - BACKGROUND: The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism (rs6265) has been associated with several neuropsychiatric disorders and regional structural brain changes in adults, but little is known about Val66Met's effect on brain morphology during typical or atypical neurodevelopment. Windows of vulnerability to psychopathology may be associated with the different alleles of the Val66Met polymorphism during childhood and adolescence. METHODOLOGY: We investigated the effect of Val66Met on cortical thickness in MRI scans of 718 children and adolescents (6-12 years old) with typical development, and in those meeting DSM criteria for a psychiatric disorder. RESULTS: Val66Met had a significant effect on cortical thickness. Considering the typically developing group, Met-carriers presented thicker parietal and occipital lobes and prefrontal cortices compared to Val homozygotes. Met-carriers with psychiatric disorders presented thicker medial and lateral temporal cortices than Val homozygotes. Furthermore, a significant genotype x psychiatric diagnosis interaction was found: Met-carriers with a psychiatric diagnosis presented thinner bilateral prefrontal cortices than Val homozygotes. CONCLUSION: This study provides evidence that Val66Met is associated with cortical maturation in children and adolescents with and without psychiatric disorders. CI - Copyright (c) 2017 Elsevier Ltd. All rights reserved. FAU - de Araujo, Celia Maria AU - de Araujo CM AD - National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq), Sao Paulo, Brazil; Department of Psychiatry, Universidade Federal de Sao Paulo, Brazil. Electronic address: celia.fit@gmail.com. FAU - Zugman, Andre AU - Zugman A AD - National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq), Sao Paulo, Brazil; Department of Psychiatry, Universidade Federal de Sao Paulo, Brazil. FAU - Swardfager, Walter AU - Swardfager W AD - Department of Pharmacology & Toxicology, University of Toronto, Toronto, Canada; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Canada. FAU - Belangero, Sintia Iole Nogueira AU - Belangero SIN AD - National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq), Sao Paulo, Brazil; Department of Psychiatry, Universidade Federal de Sao Paulo, Brazil; Department of Morphology and Genetics, Universidade Federal de Sao Paulo, Sao Paulo, Brazil. FAU - Ota, Vanessa Kiyomi AU - Ota VK AD - Department of Psychiatry, Universidade Federal de Sao Paulo, Brazil; Department of Morphology and Genetics, Universidade Federal de Sao Paulo, Sao Paulo, Brazil. FAU - Spindola, Leticia Maria AU - Spindola LM AD - Department of Psychiatry, Universidade Federal de Sao Paulo, Brazil; Department of Morphology and Genetics, Universidade Federal de Sao Paulo, Sao Paulo, Brazil. FAU - Hakonarson, Hakon AU - Hakonarson H AD - Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, United States. FAU - Pellegrino, Renata AU - Pellegrino R AD - Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, United States. FAU - Gadelha, Ary AU - Gadelha A AD - National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq), Sao Paulo, Brazil; Department of Psychiatry, Universidade Federal de Sao Paulo, Brazil. FAU - Salum, Giovanni Abrahao AU - Salum GA AD - National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq), Sao Paulo, Brazil; Department of Psychiatry, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. FAU - Pan, Pedro Mario AU - Pan PM AD - National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq), Sao Paulo, Brazil; Department of Psychiatry, Universidade Federal de Sao Paulo, Brazil. FAU - de Moura, Luciana Monteiro AU - de Moura LM AD - Mathematics & Statistics Institute, Universidade Federal do ABC, Santo Andre, Brazil. FAU - Del Aquilla, Marco AU - Del Aquilla M AD - National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq), Sao Paulo, Brazil; Department of Psychiatry, Universidade Federal de Sao Paulo, Brazil. FAU - Picon, Felipe Almeida AU - Picon FA AD - National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq), Sao Paulo, Brazil; Department of Psychiatry, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. FAU - Amaro, Edson Jr AU - Amaro E Jr AD - Institute of Radiology (INRAD), Universidade de Sao Paulo, Sao Paulo, Brazil. FAU - Sato, Joao Ricardo AU - Sato JR AD - National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq), Sao Paulo, Brazil; Mathematics & Statistics Institute, Universidade Federal do ABC, Santo Andre, Brazil. FAU - Brietzke, Elisa AU - Brietzke E AD - Department of Psychiatry, Universidade Federal de Sao Paulo, Brazil. FAU - Grassi-Oliveira, Rodrigo AU - Grassi-Oliveira R AD - Developmental Cognitive Neuroscience Laboratory (DCNL), Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil. FAU - Rohde, Luis Augusto P AU - Rohde LAP AD - National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq), Sao Paulo, Brazil; Department of Psychiatry, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. FAU - Miguel, Euripedes Constantino AU - Miguel EC AD - National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq), Sao Paulo, Brazil; Department & Institute of Psychiatry (IPq), Universidade de Sao Paulo, Sao Paulo, Brazil. FAU - Bressan, Rodrigo A AU - Bressan RA AD - National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq), Sao Paulo, Brazil; Department of Psychiatry, Universidade Federal de Sao Paulo, Brazil. FAU - Jackowski, Andrea Parolin AU - Jackowski AP AD - National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq), Sao Paulo, Brazil; Department of Psychiatry, Universidade Federal de Sao Paulo, Brazil. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20171220 PL - England TA - J Psychiatr Res JT - Journal of psychiatric research JID - 0376331 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Brain-Derived Neurotrophic Factor/*genetics MH - Brazil MH - Cerebral Cortex/*anatomy & histology/diagnostic imaging/*growth & development/pathology MH - Child MH - Child Development/*physiology MH - Cohort Studies MH - Female MH - Humans MH - Magnetic Resonance Imaging MH - Male MH - Mental Disorders/diagnostic imaging/*genetics/*pathology MH - Polymorphism, Single Nucleotide OTO - NOTNLM OT - Adolescents OT - BDNF OT - Brain morphology OT - Brain-derived neurotrophic factor OT - Children OT - Cortical thickness OT - MRI OT - Psychiatric disorders OT - Val66Met OT - rs6265 EDAT- 2017/12/31 06:00 MHDA- 2019/06/30 06:00 CRDT- 2017/12/31 06:00 PHST- 2017/07/28 00:00 [received] PHST- 2017/11/18 00:00 [revised] PHST- 2017/12/14 00:00 [accepted] PHST- 2017/12/31 06:00 [pubmed] PHST- 2019/06/30 06:00 [medline] PHST- 2017/12/31 06:00 [entrez] AID - S0022-3956(17)30759-8 [pii] AID - 10.1016/j.jpsychires.2017.12.008 [doi] PST - ppublish SO - J Psychiatr Res. 2018 Mar;98:51-58. doi: 10.1016/j.jpsychires.2017.12.008. Epub 2017 Dec 20.