PMID- 29289723
OWN - NLM
STAT- MEDLINE
DCOM- 20190131
LR  - 20190131
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Linking)
VI  - 24
IP  - 4
DP  - 2018 Apr
TI  - Diaphragm Muscle Dysfunction in Patients With Heart Failure.
PG  - 209-216
LID - S1071-9164(17)31303-9 [pii]
LID - 10.1016/j.cardfail.2017.12.004 [doi]
AB  - BACKGROUND: Inspiratory muscle weakness is associated with the development of 
      exercise intolerance in patients with heart failure (HF). Ultrasound assessment 
      of the diaphragm is used to evaluate respiratory muscle function, but its 
      application in patients with HF remains undefined. We examined the relationship 
      of diaphragm function as assessed by ultrasonography with inspiratory muscle 
      strength and exercise tolerance in HF. METHODS AND RESULTS: Seventy-seven 
      patients hospitalized with HF were enrolled. Impaired diaphragm muscle function 
      was defined as a diaphragm thickness at end-inspiration of less than the median 
      value of 4.0 mm, which represents diaphragm muscle loss and reduced contraction. 
      Compared with patients with preserved diaphragm muscle function, those with 
      impaired diaphragm muscle function were older; had significantly lower vital 
      capacity, handgrip strength, and inspiratory muscle strength as assessed by the 
      maximum inspiratory pressure; and had a significantly shorter 6-minute walk 
      distance (6MWD; P < .05). Although low handgrip strength was also associated with 
      a short 6MWD, the relationship between impaired diaphragm muscle function and 
      short 6MWD was independent from age, vital capacity, and handgrip strength. 
      CONCLUSION: Diaphragm dysfunction as assessed by ultrasonography represents 
      inspiratory muscle weakness and predicts exercise intolerance independently from 
      comorbid pulmonary dysfunction and dynapenia in patients with HF.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Miyagi, Mari
AU  - Miyagi M
AD  - Division of Cardiovascular Medicine, Department of Molecular Medicine and 
      Therapeutics, Faculty of Medicine, Tottori University, Yonago, Japan.
FAU - Kinugasa, Yoshiharu
AU  - Kinugasa Y
AD  - Division of Cardiovascular Medicine, Department of Molecular Medicine and 
      Therapeutics, Faculty of Medicine, Tottori University, Yonago, Japan. Electronic 
      address: ykinugasa-circ@umin.ac.jp.
FAU - Sota, Takeshi
AU  - Sota T
AD  - Division of Cardiovascular Medicine, Department of Molecular Medicine and 
      Therapeutics, Faculty of Medicine, Tottori University, Yonago, Japan.
FAU - Yamada, Kensaku
AU  - Yamada K
AD  - Division of Cardiovascular Medicine, Department of Molecular Medicine and 
      Therapeutics, Faculty of Medicine, Tottori University, Yonago, Japan.
FAU - Ishisugi, Takuya
AU  - Ishisugi T
AD  - Division of Cardiovascular Medicine, Department of Molecular Medicine and 
      Therapeutics, Faculty of Medicine, Tottori University, Yonago, Japan.
FAU - Hirai, Masayuki
AU  - Hirai M
AD  - Division of Cardiovascular Medicine, Department of Molecular Medicine and 
      Therapeutics, Faculty of Medicine, Tottori University, Yonago, Japan.
FAU - Yanagihara, Kiyotaka
AU  - Yanagihara K
AD  - Division of Cardiovascular Medicine, Department of Molecular Medicine and 
      Therapeutics, Faculty of Medicine, Tottori University, Yonago, Japan.
FAU - Haruki, Nobuhiko
AU  - Haruki N
AD  - Division of Cardiovascular Medicine, Department of Molecular Medicine and 
      Therapeutics, Faculty of Medicine, Tottori University, Yonago, Japan.
FAU - Matsubara, Koichi
AU  - Matsubara K
AD  - Division of Cardiovascular Medicine, Department of Molecular Medicine and 
      Therapeutics, Faculty of Medicine, Tottori University, Yonago, Japan.
FAU - Kato, Masahiko
AU  - Kato M
AD  - Division of Cardiovascular Medicine, Department of Molecular Medicine and 
      Therapeutics, Faculty of Medicine, Tottori University, Yonago, Japan.
FAU - Yamamoto, Kazuhiro
AU  - Yamamoto K
AD  - Division of Cardiovascular Medicine, Department of Molecular Medicine and 
      Therapeutics, Faculty of Medicine, Tottori University, Yonago, Japan.
LA  - eng
PT  - Journal Article
DEP - 20171228
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
SB  - IM
CIN - J Card Fail. 2018 Apr;24(4):217-218. PMID: 29499323
MH  - Aged
MH  - Diaphragm/diagnostic imaging/*physiopathology
MH  - Exercise Test
MH  - Exercise Tolerance/*physiology
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*complications/physiopathology
MH  - Humans
MH  - Male
MH  - Muscle Weakness/diagnosis/*etiology/physiopathology
MH  - ROC Curve
MH  - Respiratory Muscles/physiopathology
MH  - Retrospective Studies
MH  - Ultrasonography
OTO - NOTNLM
OT  - Diaphragm ultrasound
OT  - frailty
OT  - inspiratory muscle weakness
EDAT- 2018/01/01 06:00
MHDA- 2019/02/01 06:00
CRDT- 2018/01/01 06:00
PHST- 2017/07/05 00:00 [received]
PHST- 2017/11/04 00:00 [revised]
PHST- 2017/12/21 00:00 [accepted]
PHST- 2018/01/01 06:00 [pubmed]
PHST- 2019/02/01 06:00 [medline]
PHST- 2018/01/01 06:00 [entrez]
AID - S1071-9164(17)31303-9 [pii]
AID - 10.1016/j.cardfail.2017.12.004 [doi]
PST - ppublish
SO  - J Card Fail. 2018 Apr;24(4):209-216. doi: 10.1016/j.cardfail.2017.12.004. Epub 
      2017 Dec 28.