PMID- 29289739
OWN - NLM
STAT- MEDLINE
DCOM- 20180816
LR  - 20220409
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 79
IP  - 3
DP  - 2018 Mar
TI  - Human leukocyte antigen, allele, and eplet mismatches in liver transplantation; 
      observations from a small, single center cohort.
PG  - 154-159
LID - S0198-8859(17)30571-2 [pii]
LID - 10.1016/j.humimm.2017.12.006 [doi]
AB  - BACKGROUND: The impact of human leukocyte antigen (HLA) matching on outcomes in 
      liver transplantation is controversial. Varying levels of HLA matching 
      resolutions were examined in a uniform patient population with no pre-transplant 
      DSA from a small, single center cohort. METHODS: Retrospective chart review from 
      a single center yielded 131 patients, 67 of which were confirmed to be DSA 
      negative, all of which received induction immunotherapy and post-operative 
      immunosuppression. HLA typing was achieved by sequence specific oligonucleotide 
      probe (SSOP) method using LABType(R) kits. Eplet mismatch analysis was conducted 
      using HLAMatchMaker software. RESULTS: The mean number of HLA-A antigen 
      mismatches was significantly higher in patients experiencing acute rejection (1.8 
      vs 1.6, p = 0.006). Rejection patients more frequently possessed two HLA-A 
      mismatches compared to their non-rejection counterparts (77% vs 43%, p = 0.071). 
      Patient survival was found to be non-significantly decreased in patients with a 
      higher eplet mismatch load at the HLA-A locus (p = 0.155). No other loci were 
      found to be predictive. CONCLUSION: In conclusion, HLA mismatches were found to 
      increase acute rejection and be associated with decreased patient survival. The 
      outcomes of this study suggest an involvement of HLA-A locus mismatches in 
      predicting liver transplant rejection and patient survival.
CI  - Copyright (c) 2017 American Society for Histocompatibility and Immunogenetics. All 
      rights reserved.
FAU - Forner, David
AU  - Forner D
AD  - Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada. 
      Electronic address: David.Forner@dal.ca.
FAU - Liwski, Robert
AU  - Liwski R
AD  - Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada; 
      Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova 
      Scotia, Canada. Electronic address: Robert.Liwski@nshealth.ca.
FAU - Alwayn, Ian
AU  - Alwayn I
AD  - Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada; 
      Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada; 
      Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova 
      Scotia, Canada. Electronic address: Ian.Alwayn@nshealth.ca.
LA  - eng
PT  - Journal Article
DEP - 20171228
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Acute Disease
MH  - Cohort Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Gene Frequency
MH  - *Genotype
MH  - Graft Rejection/*genetics/mortality
MH  - HLA Antigens/*genetics
MH  - Histocompatibility
MH  - Histocompatibility Testing
MH  - Humans
MH  - Immunosuppression Therapy
MH  - *Liver Transplantation
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Survival Analysis
OTO - NOTNLM
OT  - Eplet
OT  - Human leukocyte antigen
OT  - Liver
OT  - Mismatch
OT  - Transplant
EDAT- 2018/01/01 06:00
MHDA- 2018/08/17 06:00
CRDT- 2018/01/01 06:00
PHST- 2017/07/13 00:00 [received]
PHST- 2017/11/08 00:00 [revised]
PHST- 2017/12/13 00:00 [accepted]
PHST- 2018/01/01 06:00 [pubmed]
PHST- 2018/08/17 06:00 [medline]
PHST- 2018/01/01 06:00 [entrez]
AID - S0198-8859(17)30571-2 [pii]
AID - 10.1016/j.humimm.2017.12.006 [doi]
PST - ppublish
SO  - Hum Immunol. 2018 Mar;79(3):154-159. doi: 10.1016/j.humimm.2017.12.006. Epub 2017 
      Dec 28.