PMID- 29290043 OWN - NLM STAT- MEDLINE DCOM- 20190205 LR - 20190215 IS - 1573-7365 (Electronic) IS - 0885-7490 (Linking) VI - 33 IP - 3 DP - 2018 Jun TI - The effects of vitamin E on brain derived neurotrophic factor, tissues oxidative damage and learning and memory of juvenile hypothyroid rats. PG - 713-724 LID - 10.1007/s11011-017-0176-0 [doi] AB - The effects of vitamin E (Vit E) on brain derived neurotrophic factor (BDNF) and brain tissues oxidative damage as well as on learning and memory impairments in juvenile hypothyroid rats were examined. The rats were grouped as: (1) Control; (2) Propylthiouracil (PTU); (3) PTU-Vit E and (4) Vit E. PTU was added to their drinking water (0.05%) during 6 weeks. Vit E (20 mg/kg) was daily injected (IP). Morris water maze (MWM) and passive avoidance (PA) were carried out. The animals were deeply anesthetized and the brain tissues were removed for biochemical measurements. PTU increased the escape latency and traveled path in MWM (P < 0.001). It also shortened the latency to enter the dark compartment of PA as well as the time spent in the target quadrant in probe trial of MWM (P < 0.01-P < 0.001). All the effects of PTU were reversed by Vit E (P < 0.01-P < 0.001). PTU administration attenuated thiol and BDNF content as well as the activities of superoxide dismutase (SOD) and catalase (CAT) in the brain tissues while increased molondialdehyde (MDA). Moreover, Vit E improved BDNF, thiol, SOD and CAT while diminished MDA. The results of the present study showed that Vit E improved BDNF and prevented from brain tissues oxidative damage as well as learning and memory impairments in juvenile hypothyroid rats. FAU - Baghcheghi, Yousef AU - Baghcheghi Y AD - Student Research Committee, Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Beheshti, Farimah AU - Beheshti F AD - Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Shafei, Mohammad Naser AU - Shafei MN AD - Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Salmani, Hossein AU - Salmani H AD - Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Sadeghnia, Hamid Reza AU - Sadeghnia HR AD - Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Soukhtanloo, Mohammad AU - Soukhtanloo M AD - Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Anaeigoudari, Akbar AU - Anaeigoudari A AD - Department of Physiology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran. FAU - Hosseini, Mahmoud AU - Hosseini M AD - Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. hosseinim@mums.ac.ir. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20171230 PL - United States TA - Metab Brain Dis JT - Metabolic brain disease JID - 8610370 RN - 0 (Antioxidants) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 1406-18-4 (Vitamin E) SB - IM MH - Animals MH - Antioxidants/pharmacology MH - Brain/drug effects MH - Brain-Derived Neurotrophic Factor/*drug effects/metabolism MH - Humans MH - Hypothyroidism/*drug therapy MH - Learning/*drug effects MH - Male MH - Memory/*drug effects MH - Oxidative Stress/drug effects MH - Rats, Wistar MH - Vitamin E/*pharmacology OTO - NOTNLM OT - BDNF OT - Hypothyroidism OT - Learning OT - Memory OT - Oxidative stress OT - Vitamin E EDAT- 2018/01/01 06:00 MHDA- 2019/02/06 06:00 CRDT- 2018/01/01 06:00 PHST- 2017/05/19 00:00 [received] PHST- 2017/12/25 00:00 [accepted] PHST- 2018/01/01 06:00 [pubmed] PHST- 2019/02/06 06:00 [medline] PHST- 2018/01/01 06:00 [entrez] AID - 10.1007/s11011-017-0176-0 [pii] AID - 10.1007/s11011-017-0176-0 [doi] PST - ppublish SO - Metab Brain Dis. 2018 Jun;33(3):713-724. doi: 10.1007/s11011-017-0176-0. Epub 2017 Dec 30.