PMID- 29290100
OWN - NLM
STAT- MEDLINE
DCOM- 20190830
LR  - 20240213
IS  - 1474-9726 (Electronic)
IS  - 1474-9718 (Print)
IS  - 1474-9718 (Linking)
VI  - 17
IP  - 2
DP  - 2018 Apr
TI  - Circulating levels of monocyte chemoattractant protein-1 as a potential measure 
      of biological age in mice and frailty in humans.
LID - 10.1111/acel.12706 [doi]
LID - e12706
AB  - A serum biomarker of biological versus chronological age would have significant 
      impact on clinical care. It could be used to identify individuals at risk of 
      early-onset frailty or the multimorbidities associated with old age. It may also 
      serve as a surrogate endpoint in clinical trials targeting mechanisms of aging. 
      Here, we identified MCP-1/CCL2, a chemokine responsible for recruiting monocytes, 
      as a potential biomarker of biological age. Circulating monocyte chemoattractant 
      protein-1 (MCP-1) levels increased in an age-dependent manner in wild-type (WT) 
      mice. That age-dependent increase was accelerated in Ercc1(-/Delta) and Bubr1(H/H) 
      mouse models of progeria. Genetic and pharmacologic interventions that slow aging 
      of Ercc1(-/Delta) and WT mice lowered serum MCP-1 levels significantly. Finally, in 
      elderly humans with aortic stenosis, MCP-1 levels were significantly higher in 
      frail individuals compared to nonfrail. These data support the conclusion that 
      MCP-1 can be used as a measure of mammalian biological age that is responsive to 
      interventions that extend healthy aging.
CI  - (c) 2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley 
      & Sons Ltd.
FAU - Yousefzadeh, Matthew J
AU  - Yousefzadeh MJ
AD  - Department of Molecular Medicine, Center on Aging, The Scripps Research 
      Institute, Jupiter, FL, USA.
FAU - Schafer, Marissa J
AU  - Schafer MJ
AD  - Robert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine, 
      Rochester, MN, USA.
AD  - Department of Physical Medicine and Rehabilitation, Mayo Clinic College of 
      Medicine, Rochester, MN, USA.
FAU - Noren Hooten, Nicole
AU  - Noren Hooten N
AD  - Laboratory of Epidemiology and Population Science, National Institute on Aging, 
      National Institutes of Health, Baltimore, MD, USA.
FAU - Atkinson, Elizabeth J
AU  - Atkinson EJ
AD  - Division of Biomedical Statistics and Informatics, Department of Health Sciences 
      Research, Mayo Clinic College of Medicine, Rochester, MN, USA.
FAU - Evans, Michele K
AU  - Evans MK
AD  - Laboratory of Epidemiology and Population Science, National Institute on Aging, 
      National Institutes of Health, Baltimore, MD, USA.
FAU - Baker, Darren J
AU  - Baker DJ
AD  - Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, 
      Rochester, MN, USA.
FAU - Quarles, Ellen K
AU  - Quarles EK
AD  - Department of Pathology, University of Washington, Seattle, WA, USA.
FAU - Robbins, Paul D
AU  - Robbins PD
AD  - Department of Molecular Medicine, Center on Aging, The Scripps Research 
      Institute, Jupiter, FL, USA.
FAU - Ladiges, Warren C
AU  - Ladiges WC
AD  - Department of Comparative Medicine, University of Washington, Seattle, WA, USA.
FAU - LeBrasseur, Nathan K
AU  - LeBrasseur NK
AD  - Robert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine, 
      Rochester, MN, USA.
AD  - Department of Physical Medicine and Rehabilitation, Mayo Clinic College of 
      Medicine, Rochester, MN, USA.
FAU - Niedernhofer, Laura J
AU  - Niedernhofer LJ
AD  - Department of Molecular Medicine, Center on Aging, The Scripps Research 
      Institute, Jupiter, FL, USA.
LA  - eng
GR  - R01 AG053832/AG/NIA NIH HHS/United States
GR  - R24 AG047115/AG/NIA NIH HHS/United States
GR  - R56 AG052958/AG/NIA NIH HHS/United States
GR  - T32 AG000057/AG/NIA NIH HHS/United States
GR  - Z01 AG000519/ImNIH/Intramural NIH HHS/United States
GR  - R01 AG038550/AG/NIA NIH HHS/United States
GR  - P01 AG043376/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20171231
PL  - England
TA  - Aging Cell
JT  - Aging cell
JID - 101130839
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Aged
MH  - Aging/*genetics
MH  - Animals
MH  - Chemokine CCL2/*genetics/metabolism
MH  - Frailty/*genetics
MH  - Humans
MH  - Mice
PMC - PMC5847863
OTO - NOTNLM
OT  - CCL2
OT  - biological age
OT  - biomarkers of aging
OT  - chemokine
OT  - geropathology
OT  - monocyte chemoattractant protein-1
EDAT- 2018/01/01 06:00
MHDA- 2019/08/31 06:00
PMCR- 2018/04/01
CRDT- 2018/01/01 06:00
PHST- 2017/10/26 00:00 [accepted]
PHST- 2018/01/01 06:00 [pubmed]
PHST- 2019/08/31 06:00 [medline]
PHST- 2018/01/01 06:00 [entrez]
PHST- 2018/04/01 00:00 [pmc-release]
AID - ACEL12706 [pii]
AID - 10.1111/acel.12706 [doi]
PST - ppublish
SO  - Aging Cell. 2018 Apr;17(2):e12706. doi: 10.1111/acel.12706. Epub 2017 Dec 31.