PMID- 29290187
OWN - NLM
STAT- MEDLINE
DCOM- 20180604
LR  - 20180604
IS  - 1681-7168 (Electronic)
IS  - 1022-386X (Linking)
VI  - 28
IP  - 1
DP  - 2018 Jan
TI  - Peripapillary Retinal Nerve Fiber Layer (RNFL) Thickness Measurements by Topcon 
      SD-OCT in Myopic Patients.
PG  - 26-30
LID - 10.29271/jcpsp.2018.01.26 [doi]
AB  - OBJECTIVE: To evaluate the effect of low-to-moderate myopia on peripapillary 
      retinal nerve fiber layer (RNFL) thickness measured by Topcon SD optical 
      coherence tomography (OCT). STUDY DESIGN: Cross-sectional study. PLACE AND 
      DURATION OF STUDY: Ophthalmology Department, Shifa Foundation Falahee Clinic, 
      over a period of one year starting from June 2015. METHODOLOGY: A total of 43 
      eyes of 43 patients, having mild to moderate myopic refractive error, were 
      enrolled in the study. Refractive error/spherical equivalent was calculated. RNFL 
      thickness was obtained from all four peripapillary quadrants: temporal, superior, 
      nasal, and inferior; and 12 sub-quadrants using Topcon SD OCT. Pearson 
      correlation coefficients (r) were calculated to evaluate relationships between 
      the RNFL thickness and spherical equivalent (SE) before and after adjustment for 
      ocular magnification. RESULTS: The study included 51.2% females and 48.8% males. 
      Mean age was 30.9 +/-6.45 years. Mean axial length was 24.25 +/-0.91 mm. Mean SE was 
      -3.25 +/-1.93 DS. Mean of average RNFL thickness (with Littmann's correction) was 
      97.28 +/-8.15 microm. Correlation analysis among all subjects showed that the average, 
      mean nasal quadrant, upper nasal, and inferonasal sub-quadrant RNFL thickness had 
      positive correlation with spherical equivalent (r = 0.31, p = 0.045).However, 
      correction of the magnification effect by applying Littmann formula eliminated 
      this effect. CONCLUSION: In low-to-moderate myopia, RNFL measurements vary with 
      refractive error of the eye. Since ocular magnification significantly affects the 
      RNFL measurement, it should be considered in diagnosing glaucoma.
FAU - Akhtar, Nadia
AU  - Akhtar N
AD  - Department of Ophthalmology, Federal General Hospital, Islamabad.
FAU - Kausar, Ayisha
AU  - Kausar A
AD  - Department of Ophthalmology, Shifa International Hospital, Islamabad.
FAU - Afzal, Farooq
AU  - Afzal F
AD  - Department of Ophthalmology, Shifa International Hospital, Islamabad.
FAU - Ali, Syed Khalid
AU  - Ali SK
AD  - Department of Ophthalmology, Shifa International Hospital, Islamabad.
FAU - Hamid, Nida
AU  - Hamid N
AD  - Department of Ophthalmology, Shifa International Hospital, Islamabad.
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - J Coll Physicians Surg Pak
JT  - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
JID - 9606447
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Female
MH  - Glaucoma/*pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myopia/*complications
MH  - Nerve Fibers/*pathology
MH  - Refractive Errors
MH  - Retinal Ganglion Cells/*pathology
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Acuity
MH  - Young Adult
EDAT- 2018/01/02 06:00
MHDA- 2018/06/05 06:00
CRDT- 2018/01/02 06:00
PHST- 2017/07/12 00:00 [received]
PHST- 2017/11/13 00:00 [accepted]
PHST- 2018/01/02 06:00 [entrez]
PHST- 2018/01/02 06:00 [pubmed]
PHST- 2018/06/05 06:00 [medline]
AID - 040579197 [pii]
AID - 10.29271/jcpsp.2018.01.26 [doi]
PST - ppublish
SO  - J Coll Physicians Surg Pak. 2018 Jan;28(1):26-30. doi: 10.29271/jcpsp.2018.01.26.