PMID- 29290843
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220311
IS  - 1874-2858 (Print)
IS  - 1874-2858 (Electronic)
IS  - 1874-2858 (Linking)
VI  - 11
DP  - 2017
TI  - Protective Effect of Anti-Phosphatidylserine Antibody in a Guinea Pig Model of 
      Advanced Hemorrhagic Arenavirus Infection.
PG  - 303-315
LID - 10.2174/1874285801711010303 [doi]
AB  - OBJECTIVE: Host derived markers on virally infected cells or virions may provide 
      targets for the generation of antiviral agents. Recently, we identified 
      phosphatidylserine (PS) as a host marker of virions and virally-infected cells. 
      METHODS AND MATERIALS: Under normal physiological conditions, PS is maintained on 
      the inner leaflet of the plasma membrane facing the cytosol. Following viral 
      infection, activation or pre-apoptotic changes cause PS to become externalized. 
      We have previously shown that bavituximab, a chimeric human-mouse antibody that 
      binds PS complexed with beta2-glycoprotein I (beta2GP1), protected rodents against 
      lethal Pichinde virus and cytomegalovirus infections. RESULTS: Here, we 
      determined the antiviral activity of a fully human monoclonal antibody, PGN632, 
      that directly binds to PS. Treatment with PGN632 protected 20% of guinea pigs 
      with advanced infections of the hemorrhagic arenavirus, Pichinde, from death. 
      Combining PGN632 with ribavirin improved the antiviral activity of both agents, 
      such that the combination rescued 50% of animals from death. CONCLUSION: The 
      major mechanisms of action of PGN632 appear to be opsonization of virus and 
      antibody-dependent cellular cytotoxicity of virally-infected cells. PS-targeting 
      agents may have utility in the treatment of viral diseases.
FAU - Thomas, John M
AU  - Thomas JM
AD  - The University of Texas Rio Grande Valley Department of Biology; School of 
      Medicine 1201 W. University Drive, Edinburg, Texas 78539, USA.
FAU - Thorpe, Philip E
AU  - Thorpe PE
AD  - The University of Texas Southwestern Medical Center Department of Pharmacology 
      2201 Inwood Road, Dallas, Texas 75390, USA.
LA  - eng
GR  - U01 AI077844/AI/NIAID NIH HHS/United States
PT  - Journal Article
DEP - 20171030
PL  - United Arab Emirates
TA  - Open Microbiol J
JT  - The open microbiology journal
JID - 101480482
PMC - PMC5737030
OTO - NOTNLM
OT  - Anti-phosphatidylserine
OT  - Cellular cytotoxicity
OT  - Hemorrhagic arenavirus infection
OT  - Phosphatidylserine
OT  - Pichinde virus
EDAT- 2018/01/02 06:00
MHDA- 2018/01/02 06:01
PMCR- 2017/01/01
CRDT- 2018/01/02 06:00
PHST- 2017/08/01 00:00 [received]
PHST- 2017/11/01 00:00 [revised]
PHST- 2017/11/11 00:00 [accepted]
PHST- 2018/01/02 06:00 [entrez]
PHST- 2018/01/02 06:00 [pubmed]
PHST- 2018/01/02 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - TOMICROJ-11-303 [pii]
AID - 10.2174/1874285801711010303 [doi]
PST - epublish
SO  - Open Microbiol J. 2017 Oct 30;11:303-315. doi: 10.2174/1874285801711010303. 
      eCollection 2017.