PMID- 29291607
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220311
IS  - 2093-0879 (Print)
IS  - 2093-0887 (Electronic)
IS  - 2093-0879 (Linking)
VI  - 24
IP  - 1
DP  - 2018 Jan 30
TI  - Is It Useful to Administer Probiotics Together With Proton Pump Inhibitors in 
      Children With Gastroesophageal Reflux?
PG  - 51-57
LID - 10.5056/jnm17059 [doi]
AB  - BACKGROUND/AIMS: Gastroesophageal reflux disease (GERD) is a frequent condition 
      diagnosed in children and treated with proton pump inhibitors (PPI). Long-term 
      PPI administration can alter intestinal bacterial population by suppressing the 
      gastric acid barrier and may cause diarrhea. The aim of this study is to evaluate 
      the prevalence of small intestinal bacterial overgrowth assessed by glucose 
      hydrogen breath test among children that received 12 weeks of PPI with or without 
      probiotics (Lactobacillus reuteri DSM 17938) associated, compared to controls. 
      METHODS: Glucose hydrogen breath test was performed before PPI treatment and 
      after 12 weeks of PPI treatment to 128 consecutive children with GERD (1-18 years 
      old) and a control group (120 healthy children). The children with GERD were 
      randomized into 2 groups: placebo group (64 who received PPI and placebo for 12 
      weeks) and probiotics group (64 who received PPI and probiotics for 12 weeks). 
      RESULTS: After 12 weeks of treatment, dysbiosis was detected among 56.2% of 
      children from placebo group (36/64), compared to 6.2% of children from the 
      probiotics group (4/64, P < 0.001). Bacterial overgrowth was detected in 5% of 
      controls (6/120). Probiotics group had a lower prevalence of dysbiosis, similar 
      to controls (P = 0.740). CONCLUSION: Probiotics administration decreased the rate 
      of dysbiosis among children treated with PPI.
FAU - Belei, Oana
AU  - Belei O
AD  - First Pediatric Clinic, University of Medicine and Pharmacy Victor Babes, 
      Timisoara, Romania.
FAU - Olariu, Laura
AU  - Olariu L
AD  - First Pediatric Clinic, University of Medicine and Pharmacy Victor Babes, 
      Timisoara, Romania.
FAU - Dobrescu, Andreea
AU  - Dobrescu A
AD  - Genetics Department, University of Medicine and Pharmacy Victor Babes, Timisoara, 
      Romania.
FAU - Marcovici, Tamara
AU  - Marcovici T
AD  - First Pediatric Clinic, University of Medicine and Pharmacy Victor Babes, 
      Timisoara, Romania.
FAU - Marginean, Otilia
AU  - Marginean O
AD  - First Pediatric Clinic, University of Medicine and Pharmacy Victor Babes, 
      Timisoara, Romania.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - J Neurogastroenterol Motil
JT  - Journal of neurogastroenterology and motility
JID - 101530189
PMC - PMC5753903
OTO - NOTNLM
OT  - Breath tests
OT  - Child
OT  - Dysbiosis
OT  - Probiotics
OT  - Proton pump inhibitors
COIS- Conflicts of interest: None.
EDAT- 2018/01/03 06:00
MHDA- 2018/01/03 06:01
PMCR- 2018/01/01
CRDT- 2018/01/03 06:00
PHST- 2017/04/24 00:00 [received]
PHST- 2017/08/12 00:00 [revised]
PHST- 2017/10/13 00:00 [accepted]
PHST- 2018/01/03 06:00 [entrez]
PHST- 2018/01/03 06:00 [pubmed]
PHST- 2018/01/03 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - jnm17059 [pii]
AID - jnm-24-051 [pii]
AID - 10.5056/jnm17059 [doi]
PST - ppublish
SO  - J Neurogastroenterol Motil. 2018 Jan 30;24(1):51-57. doi: 10.5056/jnm17059.