PMID- 29293024
OWN - NLM
STAT- MEDLINE
DCOM- 20200831
LR  - 20200831
IS  - 1364-6915 (Electronic)
IS  - 1360-7863 (Linking)
VI  - 23
IP  - 7
DP  - 2019 Jul
TI  - Lifespan leisure physical activity profile, brain plasticity and cognitive 
      function in old age.
PG  - 811-818
LID - 10.1080/13607863.2017.1421615 [doi]
AB  - OBJECTIVES: Despite the evidence suggesting physical activity (PA) as a major 
      factor for the prevention of age-related cognitive decline, only a few studies 
      have systematically investigated the impact of leisure PA during the lifespan 
      (LLPA). This study investigates the effects of LLPA on cognitive function (CF) 
      and brain plasticity (BP) in old age. METHOD: Participants' (n = 50, 72 +/- 5 yrs, 
      27 females) LLPA energy expenditure and volume was assessed via a validated 
      questionnaire investigating five epochs (14-80 yrs). Using current WHO PA 
      recommendations as reference, participants were stratified into energy 
      expenditure and volume groups. CF outcomes were attention, executive functions, 
      working memory and memory. BP was assessed using magnetic resonance spectroscopy 
      (MRSI) and brain derived neurotropic factor (BDNF). RESULTS: Correlation analysis 
      revealed associations of mean LLPA energy expenditure with attention (CF) and 
      N-acetylaspartate to choline ratios (NAA/Cho) (MRSI). ANOVA revealed higher 
      interference control performance (CF) and NAA/Cho in participants complying with 
      current PA recommendations (2-3 h per week) compared to non-compliers. Further CF 
      and BP outcomes including BDNF were not associated with LLPA. CONCLUSION: 
      Lifelong adherence to minimum recommended PA seems to be associated with markers 
      of cognitive function and neuronal integrity in old age.
FAU - Engeroff, Tobias
AU  - Engeroff T
AD  - a Department of Sports Medicine, Institute of Sports Sciences , Goethe University 
      , Frankfurt , Germany.
FAU - Vogt, Lutz
AU  - Vogt L
AD  - a Department of Sports Medicine, Institute of Sports Sciences , Goethe University 
      , Frankfurt , Germany.
FAU - Fleckenstein, Johannes
AU  - Fleckenstein J
AD  - a Department of Sports Medicine, Institute of Sports Sciences , Goethe University 
      , Frankfurt , Germany.
FAU - Fuzeki, Eszter
AU  - Fuzeki E
AD  - a Department of Sports Medicine, Institute of Sports Sciences , Goethe University 
      , Frankfurt , Germany.
FAU - Matura, Silke
AU  - Matura S
AD  - b Institute of General Practice , Goethe University , Frankfurt , Germany.
FAU - Pilatus, Ulrich
AU  - Pilatus U
AD  - c Institute of Neuroradiology , Goethe University Hospital , Frankfurt , Germany.
FAU - Schwarz, Sina
AU  - Schwarz S
AD  - a Department of Sports Medicine, Institute of Sports Sciences , Goethe University 
      , Frankfurt , Germany.
FAU - Deichmann, Ralf
AU  - Deichmann R
AD  - d Brain Imaging Center , Frankfurt , Germany.
FAU - Hellweg, Rainer
AU  - Hellweg R
AD  - e Neurobiology and Neurotophins Laboratroy, Department of Psychiatry and 
      Psychotherapy , Charite University Medicine , Berlin , Germany.
FAU - Pantel, Johannes
AU  - Pantel J
AD  - b Institute of General Practice , Goethe University , Frankfurt , Germany.
FAU - Banzer, Winfried
AU  - Banzer W
AD  - a Department of Sports Medicine, Institute of Sports Sciences , Goethe University 
      , Frankfurt , Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180102
PL  - England
TA  - Aging Ment Health
JT  - Aging & mental health
JID - 9705773
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - 997-55-7 (N-acetylaspartate)
RN  - N91BDP6H0X (Choline)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/metabolism/*physiology
MH  - Aspartic Acid/analogs & derivatives/metabolism
MH  - Attention/*physiology
MH  - Brain/diagnostic imaging/*metabolism
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Choline/metabolism
MH  - Energy Metabolism/*physiology
MH  - Executive Function/*physiology
MH  - Exercise/*physiology
MH  - Female
MH  - Humans
MH  - *Leisure Activities
MH  - Magnetic Resonance Spectroscopy
MH  - Male
MH  - Memory/*physiology
MH  - Memory, Short-Term/physiology
MH  - Neuronal Plasticity/*physiology
OTO - NOTNLM
OT  - Neuropsychology
OT  - brain derived neurotropic factor
OT  - brain metabolism
OT  - brain structure
OT  - exercise
OT  - lifelong
OT  - lifetime
OT  - neurobiology
EDAT- 2018/01/03 06:00
MHDA- 2020/09/01 06:00
CRDT- 2018/01/03 06:00
PHST- 2018/01/03 06:00 [pubmed]
PHST- 2020/09/01 06:00 [medline]
PHST- 2018/01/03 06:00 [entrez]
AID - 10.1080/13607863.2017.1421615 [doi]
PST - ppublish
SO  - Aging Ment Health. 2019 Jul;23(7):811-818. doi: 10.1080/13607863.2017.1421615. 
      Epub 2018 Jan 2.