PMID- 29293361
OWN - NLM
STAT- MEDLINE
DCOM- 20190715
LR  - 20220330
IS  - 1552-3365 (Electronic)
IS  - 0363-5465 (Linking)
VI  - 46
IP  - 4
DP  - 2018 Mar
TI  - The Effectiveness of Platelet-Rich Plasma Injections in Gluteal Tendinopathy: A 
      Randomized, Double-Blind Controlled Trial Comparing a Single Platelet-Rich Plasma 
      Injection With a Single Corticosteroid Injection.
PG  - 933-939
LID - 10.1177/0363546517745525 [doi]
AB  - BACKGROUND: Gluteus medius/minimus tendinopathy is a common cause of lateral hip 
      pain or greater trochanteric pain syndrome. HYPOTHESIS: There would be no 
      difference in the modified Harris Hip Score (mHHS) between a single platelet-rich 
      plasma (PRP) injection compared with a corticosteroid injection in the treatment 
      of gluteal tendinopathy. STUDY DESIGN: Randomized controlled trial; Level of 
      evidence, 1. METHODS: There were 228 consecutive patients referred with gluteal 
      tendinopathy who were screened to enroll 80 participants; 148 were excluded 
      (refusal: n = 42; previous surgery or sciatica: n = 50; osteoarthritis, n = 17; 
      full-thickness tendon tear, n = 17; other: n = 22). Participants were randomized 
      (1:1) to receive either a blinded glucocorticoid or PRP injection 
      intratendinously under ultrasound guidance. A pain and functional assessment was 
      performed using the mHHS questionnaire at 0, 2, 6, and 12 weeks and the patient 
      acceptable symptom state (PASS) and minimal clinically important difference 
      (MCID) at 12 weeks. RESULTS: Participants had a mean age of 60 years, a ratio of 
      female to male of 9:1, and mean duration of symptoms of >14 months. Pain and 
      function measured by the mean mHHS showed no difference at 2 weeks 
      (corticosteroid: 66.95 +/- 15.14 vs PRP: 65.23 +/- 11.60) or 6 weeks (corticosteroid: 
      69.51 +/- 14.78 vs PRP: 68.79 +/- 13.33). The mean mHHS was significantly improved at 
      12 weeks in the PRP group (74.05 +/- 13.92) compared with the corticosteroid group 
      (67.13 +/- 16.04) ( P = .048). The proportion of participants who achieved an 
      outcome score of >/=74 at 12 weeks was 17 of 37 (45.9%) in the corticosteroid group 
      and 25 of 39 (64.1%) in the PRP group. The proportion of participants who 
      achieved the MCID of more than 8 points at 12 weeks was 21 of 37 (56.7%) in the 
      corticosteroid group and 32 of 39 (82%) in the PRP group ( P = .016). CONCLUSION: 
      Patients with chronic gluteal tendinopathy >4 months, diagnosed with both 
      clinical and radiological examinations, achieved greater clinical improvement at 
      12 weeks when treated with a single PRP injection than those treated with a 
      single corticosteroid injection. Registration: ACTRN12613000677707 (Australian 
      New Zealand Clinical Trials Registry).
FAU - Fitzpatrick, Jane
AU  - Fitzpatrick J
AD  - School of Surgery, University of Western Australia, Crawley, Western Australia, 
      Australia.
AD  - Sports Medicine Professionals, Richmond, Victoria, Australia.
AD  - Epworth Hospital, Richmond, Victoria, Australia.
FAU - Bulsara, Max K
AU  - Bulsara MK
AD  - Institute for Health Research, University of Notre Dame, Fremantle, Western 
      Australia, Australia.
FAU - O'Donnell, John
AU  - O'Donnell J
AD  - Hip Arthroscopy Australia, Richmond, Victoria, Australia.
FAU - McCrory, Paul Robert
AU  - McCrory PR
AD  - Melbourne Brain Centre, Florey Institute of Neuroscience and Mental Health, 
      University of Melbourne, Heidelberg, Victoria, Australia.
FAU - Zheng, Ming Hao
AU  - Zheng MH
AD  - School of Surgery, University of Western Australia, Crawley, Western Australia, 
      Australia.
AD  - Translational Orthopaedic Research Centre, Sir Charles Gairdner Hospital, 
      Nedlands, Western Australia, Australia.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20180102
PL  - United States
TA  - Am J Sports Med
JT  - The American journal of sports medicine
JID - 7609541
RN  - 0 (Adrenal Cortex Hormones)
SB  - IM
CIN - Am J Sports Med. 2018 Jul;46(8):NP33-NP34. PMID: 29953293
CIN - Am J Sports Med. 2018 Jul;46(8):NP32-NP33. PMID: 29953294
CIN - Z Orthop Unfall. 2019 Feb;157(1):16-17. PMID: 30786297
CIN - Am J Phys Med Rehabil. 2020 Jul;99(7):660-662. PMID: 31361618
MH  - Adrenal Cortex Hormones/*administration & dosage
MH  - Adult
MH  - Aged
MH  - Australia
MH  - Double-Blind Method
MH  - Female
MH  - Femur/physiopathology
MH  - Humans
MH  - Injections
MH  - Male
MH  - Middle Aged
MH  - Muscle, Skeletal/physiopathology
MH  - Pain/*etiology
MH  - *Platelet-Rich Plasma
MH  - Tendinopathy/*therapy
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - gluteal tendinopathy
OT  - leukocyte
OT  - platelet-rich plasma
EDAT- 2018/01/03 06:00
MHDA- 2019/07/16 06:00
CRDT- 2018/01/03 06:00
PHST- 2018/01/03 06:00 [pubmed]
PHST- 2019/07/16 06:00 [medline]
PHST- 2018/01/03 06:00 [entrez]
AID - 10.1177/0363546517745525 [doi]
PST - ppublish
SO  - Am J Sports Med. 2018 Mar;46(4):933-939. doi: 10.1177/0363546517745525. Epub 2018 
      Jan 2.