PMID- 29294124
OWN - NLM
STAT- MEDLINE
DCOM- 20190806
LR  - 20220331
IS  - 1526-4637 (Electronic)
IS  - 1526-2375 (Linking)
VI  - 19
IP  - 8
DP  - 2018 Aug 1
TI  - Higher Cortical Facilitation and Serum BDNF Are Associated with Increased 
      Sensitivity to Heat Pain and Reduced Endogenous Pain Inhibition in Healthy Males.
PG  - 1578-1586
LID - 10.1093/pm/pnx297 [doi]
AB  - BACKGROUND: Although the brain-derived neurotrophic factor (BDNF) has been 
      intensively investigated in animal models of chronic pain, its role in human pain 
      processing is less understood. OBJECTIVE: To study the neurophysiology of BDNF 
      modulation on acute experimental pain, we performed a cross-sectional study. 
      METHODS: We recruited 20 healthy male volunteers (19-40 years old) and assessed 
      their serum BDNF levels, quantitative sensory testing, and cortical excitability 
      parameters using transcranial magnetic stimulation. RESULTS: Linear regression 
      models demonstrated that the BDNF (beta = -5.245, P = 0.034) and intracortical 
      facilitation (beta = -3.311, P = 0.034) were inversely correlated with heat pain 
      threshold (adjusted R2 = 44.26). The BDNF (beta = -3.719, P </= 0.001) was also 
      inversely correlated with conditioned pain modulation (adjusted R2 = 56.8). 
      CONCLUSIONS: Our findings indicate that higher serum BDNF and intracortical 
      facilitation of the primary motor cortex are associated with increased 
      sensitivity to heat pain and high serum BDNF with reduced pain inhibition during 
      noxious heterotopic stimulation.
FAU - Dussan-Sarria, Jairo Alberto
AU  - Dussan-Sarria JA
AD  - Postgraduation Program in Medical Sciences, School of Medicine, Universidade 
      Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
AD  - Laboratory of Pain and Neuromodulation, Hospital de Clinicas de Porto Alegre 
      (HCPA)/UFRGS, Porto Alegre, RS, Brazil.
FAU - da Silva, Nadia Regina Jardim
AU  - da Silva NRJ
AD  - Postgraduation Program in Medical Sciences, School of Medicine, Universidade 
      Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
AD  - Laboratory of Pain and Neuromodulation, Hospital de Clinicas de Porto Alegre 
      (HCPA)/UFRGS, Porto Alegre, RS, Brazil.
FAU - Deitos, Alicia
AU  - Deitos A
AD  - Postgraduation Program in Medical Sciences, School of Medicine, Universidade 
      Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
AD  - Laboratory of Pain and Neuromodulation, Hospital de Clinicas de Porto Alegre 
      (HCPA)/UFRGS, Porto Alegre, RS, Brazil.
FAU - Stefani, Luciana Cadore
AU  - Stefani LC
AD  - Postgraduation Program in Medical Sciences, School of Medicine, Universidade 
      Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
AD  - Laboratory of Pain and Neuromodulation, Hospital de Clinicas de Porto Alegre 
      (HCPA)/UFRGS, Porto Alegre, RS, Brazil.
AD  - Surgery Department, School of Medicine, HCPA/UFRGS, RS, Brazil.
FAU - Laste, Gabriela
AU  - Laste G
AD  - Postgraduation Program in Medical Sciences, School of Medicine, Universidade 
      Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
AD  - Laboratory of Pain and Neuromodulation, Hospital de Clinicas de Porto Alegre 
      (HCPA)/UFRGS, Porto Alegre, RS, Brazil.
FAU - Souza, Andressa de
AU  - Souza A
AD  - Laboratory of Pain and Neuromodulation, Hospital de Clinicas de Porto Alegre 
      (HCPA)/UFRGS, Porto Alegre, RS, Brazil.
AD  - La Salle University, Canoas, RS, Brazil.
FAU - Torres, Iraci L S
AU  - Torres ILS
AD  - Postgraduation Program in Medical Sciences, School of Medicine, Universidade 
      Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
AD  - Pharmacology Department, Instituto de Ciencias Basicas da Saude, UFRGS, Porto 
      Alegre, RS, Brazil.
FAU - Fregni, Felipe
AU  - Fregni F
AD  - Spaulding Neuromodulation Center, Spaulding Rehabilitation Hospital, Harvard 
      Medical School, Charlestown, Boston, Massachusetts, USA.
FAU - Caumo, Wolnei
AU  - Caumo W
AD  - Postgraduation Program in Medical Sciences, School of Medicine, Universidade 
      Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
AD  - Laboratory of Pain and Neuromodulation, Hospital de Clinicas de Porto Alegre 
      (HCPA)/UFRGS, Porto Alegre, RS, Brazil.
AD  - Surgery Department, School of Medicine, HCPA/UFRGS, RS, Brazil.
AD  - Pain and Palliative Care Service at HCPA, Porto Alegre, RS, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pain Med
JT  - Pain medicine (Malden, Mass.)
JID - 100894201
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cross-Sectional Studies
MH  - Healthy Volunteers
MH  - Humans
MH  - Male
MH  - Motor Cortex/*physiology
MH  - Pain Threshold/*physiology
MH  - Transcranial Magnetic Stimulation
EDAT- 2018/01/03 06:00
MHDA- 2019/08/07 06:00
CRDT- 2018/01/03 06:00
PHST- 2018/01/03 06:00 [pubmed]
PHST- 2019/08/07 06:00 [medline]
PHST- 2018/01/03 06:00 [entrez]
AID - 4780337 [pii]
AID - 10.1093/pm/pnx297 [doi]
PST - ppublish
SO  - Pain Med. 2018 Aug 1;19(8):1578-1586. doi: 10.1093/pm/pnx297.