PMID- 29294307
OWN - NLM
STAT- MEDLINE
DCOM- 20181023
LR  - 20181202
IS  - 1090-2422 (Electronic)
IS  - 0014-4827 (Linking)
VI  - 363
IP  - 1
DP  - 2018 Feb 1
TI  - Tsc1-dependent transcriptional programming of dendritic cell homeostasis and 
      function.
PG  - 73-83
LID - S0014-4827(17)30690-0 [pii]
LID - 10.1016/j.yexcr.2017.12.028 [doi]
AB  - Dendritic cells (DCs) are pivotal to initiating adaptive immune response. 
      Emerging evidence highlights important roles of tuberous sclerosis complex 1 
      (Tsc1) in DC development and activation. Our previous study also showed that Tsc1 
      expression in DCs was required to promote T-cell homeostasis and response 
      partially through inhibiting mammalian target of rapamycin complex1 (mTORC1). 
      However, the molecular mechanism of transcriptional regulation by which Tsc1 
      control DC homeostasis and function remains largely unknown. Here we globally 
      identified the Tsc1-regulated genes by comparing the transcriptional profiling of 
      Tsc1-deficient DCs with wild-type DCs. It showed that Tsc1 specifically regulated 
      the expression of groups of gene sets critically involved in DC survival, 
      proliferation, metabolism and antigen presentation. The impacts of Tsc1 on DC 
      gene expression were partially dependent on inhibition of mTORC1 signal. Our 
      study thus provides a comprehensive molecular basis for understanding how Tsc1 
      programs the homeostasis and function of DCs through transcriptional regulation.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Luo, Yuechen
AU  - Luo Y
AD  - State Key Laboratory of Experimental Hematology, Institute of Hematology and 
      Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union 
      Medical College, Tianjin 300020, China.
FAU - Liu, Jingru
AU  - Liu J
AD  - Central Laboratory, The Union Hospital of Fujian Medical University, 29 Xinquan 
      Road, Fuzhou 350001, China.
FAU - Sun, Xiaolei
AU  - Sun X
AD  - State Key Laboratory of Experimental Hematology, Institute of Hematology and 
      Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union 
      Medical College, Tianjin 300020, China.
FAU - Feng, Tiantian
AU  - Feng T
AD  - State Key Laboratory of Experimental Hematology, Institute of Hematology and 
      Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union 
      Medical College, Tianjin 300020, China.
FAU - Fang, Lijun
AU  - Fang L
AD  - State Key Laboratory of Experimental Hematology, Institute of Hematology and 
      Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union 
      Medical College, Tianjin 300020, China.
FAU - Chen, Song
AU  - Chen S
AD  - State Key Laboratory of Experimental Hematology, Institute of Hematology and 
      Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union 
      Medical College, Tianjin 300020, China.
FAU - Fang, Chunmin
AU  - Fang C
AD  - State Key Laboratory of Experimental Hematology, Institute of Hematology and 
      Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union 
      Medical College, Tianjin 300020, China.
FAU - Feng, Xiaoming
AU  - Feng X
AD  - State Key Laboratory of Experimental Hematology, Institute of Hematology and 
      Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union 
      Medical College, Tianjin 300020, China. Electronic address: 
      fengxiaoming@ihcams.ac.cn.
FAU - Huang, Huifang
AU  - Huang H
AD  - Central Laboratory, The Union Hospital of Fujian Medical University, 29 Xinquan 
      Road, Fuzhou 350001, China. Electronic address: huanghuif@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171230
PL  - United States
TA  - Exp Cell Res
JT  - Experimental cell research
JID - 0373226
RN  - 0 (Multiprotein Complexes)
RN  - 0 (Tsc1 protein, mouse)
RN  - 0 (Tuberous Sclerosis Complex 1 Protein)
RN  - 0 (Tumor Suppressor Proteins)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/immunology
MH  - Dendritic Cells/*cytology/immunology
MH  - Gene Expression Regulation/drug effects
MH  - Homeostasis/drug effects/*physiology
MH  - Mechanistic Target of Rapamycin Complex 1/*antagonists & inhibitors
MH  - Mice, Transgenic
MH  - Multiprotein Complexes/metabolism
MH  - Tuberous Sclerosis Complex 1 Protein
MH  - Tumor Suppressor Proteins/genetics/*metabolism
OTO - NOTNLM
OT  - Dendritic cells
OT  - Mammalian target of rapamycin
OT  - Transcriptional regulation
OT  - Tuberous sclerosis complex 1
EDAT- 2018/01/03 06:00
MHDA- 2018/10/24 06:00
CRDT- 2018/01/03 06:00
PHST- 2017/09/27 00:00 [received]
PHST- 2017/12/21 00:00 [revised]
PHST- 2017/12/29 00:00 [accepted]
PHST- 2018/01/03 06:00 [pubmed]
PHST- 2018/10/24 06:00 [medline]
PHST- 2018/01/03 06:00 [entrez]
AID - S0014-4827(17)30690-0 [pii]
AID - 10.1016/j.yexcr.2017.12.028 [doi]
PST - ppublish
SO  - Exp Cell Res. 2018 Feb 1;363(1):73-83. doi: 10.1016/j.yexcr.2017.12.028. Epub 
      2017 Dec 30.