PMID- 29295520
OWN - NLM
STAT- MEDLINE
DCOM- 20180727
LR  - 20181113
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 19
IP  - 1
DP  - 2017 Dec 23
TI  - The Origin of Skin Dendritic Cell Network and Its Role in Psoriasis.
LID - 10.3390/ijms19010042 [doi]
LID - 42
AB  - Dendritic cells (DCs) are heterogeneous groups of innate immune cells, which 
      orchestrate immune responses by presenting antigens to cognate T cells and 
      stimulating other types of immune cells. Although the term 'DCs' generally 
      represent highly mixed subsets with functional heterogeneity, the classical 
      definition of DCs usually denotes conventional DCs (cDCs). Skin contains a unique 
      DC network mainly composed of embryo precursor-derived epidermal Langerhans cells 
      (LCs) and bone marrow-derived dermal cDCs, which can be further classified into 
      type 1 (cDC1) and type 2 (cDC2) subsets. Psoriasis is a chronic inflammatory skin 
      disease, which is principally mediated by IL-23/IL-17 cytokine axis. In the 
      psoriatic skins, DCs are prominent cellular sources for TNF-alpha and IL-23, and the 
      use of blocking antibodies against TNF-alpha and IL-23 leads to a significant 
      clinical improvement in psoriatic patients. Recent elegant human and mouse 
      studies have shown that inflammation-induced inflammatory DCs, LCs, dermal cDC2, 
      and monocyte-derived DCs are pivotal DC subsets in psoriatic inflammation. Thus, 
      targeting specific pathogenic DC subsets would be a potential strategy for 
      alleviating and preventing DC-derived IL-23-dependent psoriatic inflammation and 
      other inflammatory dermatoses in the future.
FAU - Kim, Tae-Gyun
AU  - Kim TG
AUID- ORCID: 0000-0002-2116-4579
AD  - Department of Dermatology, Cutaneous Biology Research Institute, Severance 
      Hospital, Yonsei University College of Medicine, Seoul 03722 Korea. 
      tgmed83@yuhs.ac.
FAU - Kim, Sung Hee
AU  - Kim SH
AD  - Department of Dermatology, Cutaneous Biology Research Institute, Severance 
      Hospital, Yonsei University College of Medicine, Seoul 03722 Korea. 
      SYPZWSH@yuhs.ac.
FAU - Lee, Min-Geol
AU  - Lee MG
AD  - Department of Dermatology, Cutaneous Biology Research Institute, Severance 
      Hospital, Yonsei University College of Medicine, Seoul 03722 Korea. 
      mglee@yuhs.ac.
AD  - Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of 
      Medicine, Seoul 03722, Korea. mglee@yuhs.ac.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20171223
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*pathology
MH  - Humans
MH  - Models, Biological
MH  - Psoriasis/*pathology
MH  - Skin/*pathology
PMC - PMC5795992
OTO - NOTNLM
OT  - dendritic cells
OT  - ontogeny
OT  - psoriasis
OT  - skin
COIS- The authors declare no conflict of interest.
EDAT- 2018/01/04 06:00
MHDA- 2018/07/28 06:00
PMCR- 2018/01/01
CRDT- 2018/01/04 06:00
PHST- 2017/11/27 00:00 [received]
PHST- 2017/12/14 00:00 [revised]
PHST- 2017/12/21 00:00 [accepted]
PHST- 2018/01/04 06:00 [entrez]
PHST- 2018/01/04 06:00 [pubmed]
PHST- 2018/07/28 06:00 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - ijms19010042 [pii]
AID - ijms-19-00042 [pii]
AID - 10.3390/ijms19010042 [doi]
PST - epublish
SO  - Int J Mol Sci. 2017 Dec 23;19(1):42. doi: 10.3390/ijms19010042.