PMID- 29296509
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2159-2780 (Print)
IS  - 2159-2799 (Electronic)
IS  - 2159-2780 (Linking)
VI  - 7
IP  - 4
DP  - 2017
TI  - Amino acid and small GTPase regulation of mTORC1.
PG  - e1378794
LID - 10.1080/21592799.2017.1378794 [doi]
LID - e1378794
AB  - The mammalian target of rapamycin (mTOR) is an evolutionarily conserved 
      serine/threonine kinase that belongs to the phosphatidylinositol 3-kinase-related 
      kinase (PIKK) family. mTOR is the catalytic subunit of mTOR complex 1 (mTORC1), 
      which integrates multiple environmental signals to control cell growth and 
      metabolism. Nutrients, specifically amino acids, are the most potent stimuli for 
      mTORC1 activation. Multiple studies have focused on how leucine and arginine 
      activate mTORC1 through the Rag GTPases, with mechanistic details slowly 
      emerging. Recently, a Rag GTPase-independent glutamine signaling pathway to 
      mTORC1 has been identified, suggesting that mTORC1 is differentially regulated 
      through distinct pathways by specific amino acids. In this review, we summarize 
      our current understanding of how amino acids modulate mTORC1, and the role of 
      other small GTPases in the regulation of mTORC1 activity.
FAU - Nguyen, Thu P
AU  - Nguyen TP
AD  - Department of Molecular Biology, University of Texas Southwestern Medical Center, 
      Dallas, TX USA.
AD  - Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern 
      Medical Center, Dallas, TX USA.
FAU - Frank, Anderson R
AU  - Frank AR
AD  - Department of Molecular Biology, University of Texas Southwestern Medical Center, 
      Dallas, TX USA.
AD  - Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern 
      Medical Center, Dallas, TX USA.
FAU - Jewell, Jenna L
AU  - Jewell JL
AD  - Department of Molecular Biology, University of Texas Southwestern Medical Center, 
      Dallas, TX USA.
AD  - Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern 
      Medical Center, Dallas, TX USA.
LA  - eng
GR  - T32 GM007062/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20170929
PL  - United States
TA  - Cell Logist
JT  - Cellular logistics
JID - 101556177
PMC - PMC5739091
OTO - NOTNLM
OT  - Amino Acid
OT  - Arf1
OT  - Rag
OT  - Small GTPase
OT  - mTORC1
EDAT- 2018/01/04 06:00
MHDA- 2018/01/04 06:01
PMCR- 2017/09/29
CRDT- 2018/01/04 06:00
PHST- 2017/08/09 00:00 [received]
PHST- 2017/09/06 00:00 [revised]
PHST- 2017/09/08 00:00 [accepted]
PHST- 2018/01/04 06:00 [entrez]
PHST- 2018/01/04 06:00 [pubmed]
PHST- 2018/01/04 06:01 [medline]
PHST- 2017/09/29 00:00 [pmc-release]
AID - 1378794 [pii]
AID - 10.1080/21592799.2017.1378794 [doi]
PST - epublish
SO  - Cell Logist. 2017 Sep 29;7(4):e1378794. doi: 10.1080/21592799.2017.1378794. 
      eCollection 2017.