PMID- 29297708
OWN - NLM
STAT- MEDLINE
DCOM- 20180924
LR  - 20180924
IS  - 1366-5804 (Electronic)
IS  - 1354-750X (Linking)
VI  - 23
IP  - 3
DP  - 2018 May
TI  - Determinants of elevated carbohydrate antigen 125 in patients with severe 
      symptomatic aortic valve stenosis referred for transcatheter aortic valve 
      implantation.
PG  - 299-304
LID - 10.1080/1354750X.2018.1423706 [doi]
AB  - PURPOSE: Elevated carbohydrate antigen 125 (CA125) predicts adverse outcome after 
      transcatheter aortic valve implantation (TAVI). While known underlying 
      pathophysiological mechanisms of elevated CA125 include serosal effusions and 
      inflammatory stimuli, clinical determinants associated with elevated CA125 in 
      patients referred for TAVI remain unknown. Therefore, we investigated clinical, 
      laboratory and echocardiographic determinants of elevated CA125 in patients with 
      severe aortic valve stenosis referred for TAVI. METHODS: This study includes 650 
      patients with severe aortic stenosis referred for TAVI. Baseline CA125 was 
      determined by an immunoassay and dichotomized (elevated versus normal) based on 
      the manufacturer cutoff value (>35 U/mL). RESULTS: CA125 elevation was present in 
      28% (181/650). Patients with elevated CA125 had an overall worse clinical profile 
      and were more symptomatic with a higher rate of NYHA class III/IV (80% versus 
      58%; p < 0.001). In a multivariate analysis, independent predictors of elevated 
      CA125 were New York Heart Association (NYHA) class, baseline hemoglobin, 
      C-reactive protein (CRP), left ventricular ejection fraction and severe tricuspid 
      regurgitation. CONCLUSION: Elevated CA125 levels in patients referred for TAVI 
      summarize a subset of patients with an overall worse clinical profile who are 
      more symptomatic.
FAU - Rheude, Tobias
AU  - Rheude T
AUID- ORCID: 0000-0002-3426-6080
AD  - a Klinik fur Herz- und Kreislauferkrankungen, Deutsches Herzzentrum Munchen, 
      Technische Universitat Munchen , Munich , Germany.
FAU - Pellegrini, Costanza
AU  - Pellegrini C
AUID- ORCID: 0000-0001-5143-8203
AD  - a Klinik fur Herz- und Kreislauferkrankungen, Deutsches Herzzentrum Munchen, 
      Technische Universitat Munchen , Munich , Germany.
FAU - Reinhard, Wibke
AU  - Reinhard W
AD  - a Klinik fur Herz- und Kreislauferkrankungen, Deutsches Herzzentrum Munchen, 
      Technische Universitat Munchen , Munich , Germany.
FAU - Trenkwalder, Teresa
AU  - Trenkwalder T
AD  - a Klinik fur Herz- und Kreislauferkrankungen, Deutsches Herzzentrum Munchen, 
      Technische Universitat Munchen , Munich , Germany.
FAU - Koenig, Wolfgang
AU  - Koenig W
AD  - a Klinik fur Herz- und Kreislauferkrankungen, Deutsches Herzzentrum Munchen, 
      Technische Universitat Munchen , Munich , Germany.
AD  - b DZHK (German Centre for Cardiovascular Research), partner site Munich Heart 
      Alliance , Munich , Germany.
FAU - Mayr, N Patrick
AU  - Mayr NP
AUID- ORCID: 0000-0002-3549-3007
AD  - c Institut fur Anasthesiologie, Deutsches Herzzentrum Munchen, Technische 
      Universitat Munchen , Munich , Germany.
FAU - Joner, Michael
AU  - Joner M
AD  - a Klinik fur Herz- und Kreislauferkrankungen, Deutsches Herzzentrum Munchen, 
      Technische Universitat Munchen , Munich , Germany.
FAU - Nunez, Julio
AU  - Nunez J
AD  - d Department of Cardiology , Hospital Clinico Universitario, INCLIVA, Universidad 
      de Valencia , CIBER-CV , Valencia , Spain.
FAU - Holdenrieder, Stefan
AU  - Holdenrieder S
AD  - e Institut fur Laboratoriumsmedizin, Deutsches Herzzentrum Munchen, Technische 
      Universitat Munchen , Munich , Germany.
FAU - Schunkert, Heribert
AU  - Schunkert H
AD  - a Klinik fur Herz- und Kreislauferkrankungen, Deutsches Herzzentrum Munchen, 
      Technische Universitat Munchen , Munich , Germany.
AD  - b DZHK (German Centre for Cardiovascular Research), partner site Munich Heart 
      Alliance , Munich , Germany.
FAU - Kastrati, Adnan
AU  - Kastrati A
AD  - a Klinik fur Herz- und Kreislauferkrankungen, Deutsches Herzzentrum Munchen, 
      Technische Universitat Munchen , Munich , Germany.
AD  - b DZHK (German Centre for Cardiovascular Research), partner site Munich Heart 
      Alliance , Munich , Germany.
FAU - Hengstenberg, Christian
AU  - Hengstenberg C
AUID- ORCID: 0000-0002-8284-2994
AD  - a Klinik fur Herz- und Kreislauferkrankungen, Deutsches Herzzentrum Munchen, 
      Technische Universitat Munchen , Munich , Germany.
FAU - Husser, Oliver
AU  - Husser O
AD  - a Klinik fur Herz- und Kreislauferkrankungen, Deutsches Herzzentrum Munchen, 
      Technische Universitat Munchen , Munich , Germany.
LA  - eng
PT  - Journal Article
DEP - 20180115
PL  - England
TA  - Biomarkers
JT  - Biomarkers : biochemical indicators of exposure, response, and susceptibility to 
      chemicals
JID - 9606000
RN  - 0 (CA-125 Antigen)
RN  - 0 (Hemoglobins)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aortic Valve Stenosis/*blood/surgery
MH  - C-Reactive Protein
MH  - CA-125 Antigen/*blood
MH  - Hemoglobins
MH  - Humans
MH  - Risk Assessment
MH  - Risk Factors
MH  - *Transcatheter Aortic Valve Replacement
MH  - Tricuspid Valve Insufficiency
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - aortic valve stenosis
OT  - biochemical markers
OT  - carbohydrate antigen 125
OT  - transcatheter aortic valve stenosis
EDAT- 2018/01/04 06:00
MHDA- 2018/09/25 06:00
CRDT- 2018/01/04 06:00
PHST- 2018/01/04 06:00 [pubmed]
PHST- 2018/09/25 06:00 [medline]
PHST- 2018/01/04 06:00 [entrez]
AID - 10.1080/1354750X.2018.1423706 [doi]
PST - ppublish
SO  - Biomarkers. 2018 May;23(3):299-304. doi: 10.1080/1354750X.2018.1423706. Epub 2018 
      Jan 15.