PMID- 29298278
OWN - NLM
STAT- MEDLINE
DCOM- 20180503
LR  - 20180816
IS  - 0172-780X (Print)
IS  - 0172-780X (Linking)
VI  - 38
IP  - 6
DP  - 2017 Dec
TI  - The impact of air pollution to central nervous system in children and adults.
PG  - 389-396
AB  - The aim of this paper was to review studies analyzing the associations between 
      air pollution and neurodevelopment in children as well as the effect on adult 
      population. Effect of prenatal exposure to polycyclic aromatic hydrocarbons 
      (PAHs, benzo[a]pyrene, B[a]P) were already studied on cohorts from New York, 
      Poland, China, and Spain. All results indicate changes of child behavior and 
      neurodevelopment at the age of 3-9 years, decrease of IQ, increase of Attention 
      Deficit Hyperactivity Disorder (ADHD), decrease of brain-derived neurotrophic 
      factor (BDNF), reduction of left hemisphere white matter. Effect of 
      traffic-related air pollution (TRAP) to neurobehavioral development in children, 
      measured as PM2.5 (particulate matter <2.5 microm), PM10, elemental carbon (EC), 
      black smoke (BC), NO2, NOx, were studied in USA, Spain, Italy, and South Korea. 
      Increased concentrations of TRAP were associated with the increase of ADHD, 
      autism, affected cognitive development; PM2.5 decreased the expression of BDNF in 
      placenta. Increased concentrations of PM2.5 affected adults cognition (episodic 
      memory), increased major depressive disorders. Increased concentrations of NO2 
      were associated with dementia, NOx with Parkinson's disease. Increased 
      concentrations of PAHs, PM2.5 and NO2 in polluted air significantly affect 
      central nervous system in children and adults and represent a significant risk 
      factor for human health.
FAU - Sram, Radim J
AU  - Sram RJ
AD  - Department of Genetic Toxicology and Nanotoxicology, Institute of Experimental 
      Medicine, Acadey of Sciences, Prague, Czech Republic.
FAU - Veleminsky, Milos Jr
AU  - Veleminsky M Jr
AD  - Faculty of Health and Social Studies, South Bohemian University, Ceske 
      Budejovice, Czech Republic.
FAU - Veleminsky, Milos Sr
AU  - Veleminsky M Sr
AD  - Faculty of Health and Social Studies, South Bohemian University, Ceske 
      Budejovice, Czech Republic.
FAU - Stejskalova, Jana
AU  - Stejskalova J
AD  - Faculty of Health and Social Studies, South Bohemian University, Ceske 
      Budejovice, Czech Republic.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Sweden
TA  - Neuro Endocrinol Lett
JT  - Neuro endocrinology letters
JID - 8008373
RN  - 0 (Air Pollutants)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Air Pollutants/*toxicity
MH  - *Air Pollution
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Central Nervous System/*drug effects/metabolism
MH  - Child
MH  - Child Behavior/*drug effects
MH  - Child Development/*drug effects
MH  - Cognition/*drug effects
MH  - *Environmental Exposure
MH  - Humans
MH  - White Matter/drug effects/metabolism
EDAT- 2018/01/04 06:00
MHDA- 2018/05/04 06:00
CRDT- 2018/01/04 06:00
PHST- 2017/07/08 00:00 [received]
PHST- 2017/08/23 00:00 [accepted]
PHST- 2018/01/04 06:00 [pubmed]
PHST- 2018/05/04 06:00 [medline]
PHST- 2018/01/04 06:00 [entrez]
AID - NEL380617R01 [pii]
PST - ppublish
SO  - Neuro Endocrinol Lett. 2017 Dec;38(6):389-396.