PMID- 29299199
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220311
IS  - 2008-3866 (Print)
IS  - 2008-3874 (Electronic)
IS  - 2008-3866 (Linking)
VI  - 20
IP  - 11
DP  - 2017 Nov
TI  - Swimming training alleviated insulin resistance through Wnt3a/beta-catenin signaling 
      in type 2 diabetic rats.
PG  - 1220-1226
LID - 10.22038/IJBMS.2017.9473 [doi]
AB  - OBJECTIVES: Increasing evidence suggests that regular physical exercise improves 
      type 2 diabetes mellitus (T2DM). However, the potential beneficial effects of 
      swimming on insulin resistance and lipid disorder in T2DM, and its underlying 
      mechanisms remain unclear. MATERIALS AND METHODS: Rats were fed with high fat 
      diet and given a low dosage of Streptozotocin (STZ) to induce T2DM model, and 
      subsequently treated with or without swimming exercise. An 8-week swimming 
      program (30, 60 or 120 min per day, 5 days per week) decreased body weight, 
      fasting blood glucose and fasting insulin. RESULTS: Swimming ameliorated lipid 
      disorder, improved muscular atrophy and revealed a reduced glycogen deposit in 
      skeletal muscles of diabetic rats. Furthermore, swimming also inhibited the 
      activation of Wnt3a/beta-catenin signaling pathway, decreased Wnt3a mRNA and protein 
      level, upregulated GSK3beta phosphorylation activity and reduced the expression of 
      beta-catenin phosphorylation in diabetic rats. CONCLUSION: The trend of the result 
      suggests that swimming exercise proved to be a potent ameliorator of insulin 
      resistancein T2DM through the modulation of Wnt3a/beta-catenin pathway and 
      therefore, could present a promising therapeutic measure towards the treatment of 
      diabetes and its relatives.
FAU - Yang, Qiang
AU  - Yang Q
AD  - Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou 221002, 
      Jiangsu, China.
FAU - Wang, Wen-Wen
AU  - Wang WW
AD  - Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou 221002, 
      Jiangsu, China.
FAU - Ma, Pu
AU  - Ma P
AD  - Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou 221002, 
      Jiangsu, China.
FAU - Ma, Zhong-Xuan
AU  - Ma ZX
AD  - Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou 221002, 
      Jiangsu, China.
FAU - Hao, Meng
AU  - Hao M
AD  - Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou 221002, 
      Jiangsu, China.
FAU - Adelusi, Temitope I
AU  - Adelusi TI
AD  - Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou 221002, 
      Jiangsu, China.
FAU - Lei-Du
AU  - Lei-Du
AD  - Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou 221002, 
      Jiangsu, China.
FAU - Yin, Xiao-Xing
AU  - Yin XX
AD  - Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou 221002, 
      Jiangsu, China.
FAU - Lu, Qian
AU  - Lu Q
AD  - Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou 221002, 
      Jiangsu, China.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Basic Med Sci
JT  - Iranian journal of basic medical sciences
JID - 101517966
PMC - PMC5749356
OTO - NOTNLM
OT  - GSK3beta
OT  - Insulin resistance
OT  - Swimming training
OT  - Type 2 diabetes mellitus
OT  - Wnt3a/beta-catenin - signaling
EDAT- 2018/01/05 06:00
MHDA- 2018/01/05 06:01
PMCR- 2017/11/01
CRDT- 2018/01/05 06:00
PHST- 2018/01/05 06:00 [entrez]
PHST- 2018/01/05 06:00 [pubmed]
PHST- 2018/01/05 06:01 [medline]
PHST- 2017/11/01 00:00 [pmc-release]
AID - IJBMS-20-1220 [pii]
AID - 10.22038/IJBMS.2017.9473 [doi]
PST - ppublish
SO  - Iran J Basic Med Sci. 2017 Nov;20(11):1220-1226. doi: 10.22038/IJBMS.2017.9473.