PMID- 29299339
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220314
IS  - 2056-5933 (Print)
IS  - 2056-5933 (Electronic)
IS  - 2056-5933 (Linking)
VI  - 3
IP  - 2
DP  - 2017
TI  - Is there a relationship between spondyloarthritis and periodontitis? A 
      case-control study.
PG  - e000547
LID - 10.1136/rmdopen-2017-000547 [doi]
LID - e000547
AB  - OBJECTIVE: To compare the frequency and severity of periodontitis in patients 
      with spondyloarthritis (SpA) with healthy control individuals, through the 
      evaluation of clinical, serological and microbiological periodontal condition. 
      METHODS: Patients with a diagnosis of SpA (n=78) and biological disease-modifying 
      antirheumatic drug (bDMARD) naive fulfilling the Assessment of SpondyloArthritis 
      international Society (ASAS) classification criteria as well as 156 healthy 
      controls matched for age/gender were included. Two trained and calibrated 
      periodontologists performed the periodontal clinical assessment. The presence of 
      periodontitis and its severity were determined according to the criteria 
      established by the Centers for Disease Control and Prevention-American Academy of 
      Periodontology. The clinical periodontal variables, IgG1/IgG2 antibodies against 
      Porphyromonas gingivalis andperiodontopathic bacterial identification, were also 
      established. Comparisons of periodontal characteristics between the patients with 
      SpA and the control group were performed using univariable analyses. A logistic 
      regression analyses was performed to calculate the OR (95% CI) for diagnosis of 
      periodontitis in patients with SpA and matched controls. RESULTS: A diagnosis of 
      periodontitis was established in 56% in patients with SpA versus 69% of healthy 
      controls (P</= 0.01). Severe periodontitis was found in 3% versus 12% in SpA versus 
      healthy controls, respectively (P</= 0.01). There was no significant increase of 
      frequency of any periodontal variable, IgG1/IgG2 antibodies against P. gingivalis 
      or the presence of periodontopathic bacteria between patients with SpA and 
      control group. Periodontitis was not positively associated with a diagnosis of 
      SpA (OR: 0.57, 95% CI 0.32 to 1.00, P=0.05) in the logistic regression analyses. 
      CONCLUSIONS: We found a lower rather than a higher frequency and severity of 
      periodontitis in patients with SpA in comparison with healthy control 
      individuals. Our findings suggest that there is no positive association between 
      SpA and periodontitis in Colombian patients.
FAU - Bautista-Molano, Wilson
AU  - Bautista-Molano W
AUID- ORCID: 0000-0003-0684-9542
AD  - Rheumatology Department, Leiden University Medical Center, Leiden, The 
      Netherlands.
AD  - Rheumatology Department, School of Medicine, Universidad Militar Nueva Granada 
      and Hospital Militar, Bogota, Colombia.
AD  - Unit of Oral Basic Investigation, School of Dentistry, Universidad El Bosque, 
      Bogota, Colombia.
FAU - van der Heijde, Desiree
AU  - van der Heijde D
AD  - Rheumatology Department, Leiden University Medical Center, Leiden, The 
      Netherlands.
FAU - Landewe, Robert
AU  - Landewe R
AD  - Amsterdam Rheumatology & Clinical Immunology Center, Amsterdam, The Netherlands.
AD  - Zuyderland Medical Center Heerlen, Heerlen, The Netherlands.
FAU - Lafaurie, Gloria I
AU  - Lafaurie GI
AD  - Unit of Oral Basic Investigation, School of Dentistry, Universidad El Bosque, 
      Bogota, Colombia.
FAU - de Avila, Juliette
AU  - de Avila J
AD  - Unit of Oral Basic Investigation, School of Dentistry, Universidad El Bosque, 
      Bogota, Colombia.
FAU - Valle-Onate, Rafael
AU  - Valle-Onate R
AD  - Rheumatology Department, School of Medicine, Universidad Militar Nueva Granada 
      and Hospital Militar, Bogota, Colombia.
FAU - Romero-Sanchez, Consuelo
AU  - Romero-Sanchez C
AD  - Rheumatology Department, School of Medicine, Universidad Militar Nueva Granada 
      and Hospital Militar, Bogota, Colombia.
AD  - Unit of Oral Basic Investigation, School of Dentistry, Universidad El Bosque, 
      Bogota, Colombia.
LA  - eng
PT  - Journal Article
DEP - 20171210
PL  - England
TA  - RMD Open
JT  - RMD open
JID - 101662038
PMC - PMC5729302
OTO - NOTNLM
OT  - epidemiology
OT  - outcomes research
OT  - spondyloarthritis
COIS- Competing interests: None declared.
EDAT- 2018/01/05 06:00
MHDA- 2018/01/05 06:01
PMCR- 2017/12/10
CRDT- 2018/01/05 06:00
PHST- 2017/07/30 00:00 [received]
PHST- 2017/10/31 00:00 [revised]
PHST- 2017/11/01 00:00 [accepted]
PHST- 2018/01/05 06:00 [entrez]
PHST- 2018/01/05 06:00 [pubmed]
PHST- 2018/01/05 06:01 [medline]
PHST- 2017/12/10 00:00 [pmc-release]
AID - rmdopen-2017-000547 [pii]
AID - 10.1136/rmdopen-2017-000547 [doi]
PST - epublish
SO  - RMD Open. 2017 Dec 10;3(2):e000547. doi: 10.1136/rmdopen-2017-000547. eCollection 
      2017.