PMID- 29299987 OWN - NLM STAT- MEDLINE DCOM- 20190610 LR - 20220331 IS - 1875-6212 (Electronic) IS - 1570-1611 (Linking) VI - 16 IP - 6 DP - 2018 TI - Atherogenic Index of Plasma is Associated with Body Fat Level in Type 2 Diabetes Mellitus Patients. PG - 589-595 LID - 10.2174/1570161116666180103125456 [doi] AB - OBJECTIVE: To investigate the characteristics of body fat distribution and the relationship between body fat index and Atherogenic Index of Plasma (AIP) in Type 2 Diabetes Mellitus (T2DM) patients. METHODS: A total of 316 participants were divided into a T2DM group and a non-diabetes group (controls). According to the Visceral Fat Area (VFA), all participants were further divided into VFA >/=100 cm2 and VFA <100 cm2 groups. To compare the differences of blood lipid, blood glucose, body fat index and AIP between the 2 groups, single factor correlation analysis was used to determine the correlation between the indexes and AIP, and multiple linear regression was used to analyse the correlation between the related factors and AIP. RESULTS: The body fat index (including body fat content, Percentage of Body Fat (PBF), Waist to Hip Fat Ratio (WHR) and VFA), Triglyceride (TG), Fasting Insulin (FINS), Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and AIP in T2DM group were significantly higher than in the control group, while High Density Lipoprotein Cholesterol (HDL-C) level was significantly higher in the control group. In the VFA>/=100 cm2 group, TG, Low Density Lipoprotein Cholesterol (LDL-C), FINS, HOMAIR and AIP were all higher than that in the VFA <100 cm2 group. There was a positive correlation between AIP and VFA, body fat content, percentage of body fat, and WHR, respectively. There was also a negative correlation between AIP and HDL-C, which was not related to age, sex, Fasting Glucose (FPG), glycosylated haemoglobin (HbA1c), Total Cholesterol (TC), LDL-C and course of disease. Compared with the VFA <100 cm2 group, the VFA >/=100 cm2 group had higher blood Uric Acid (UA) levels and UA was positively correlated with VFA. After correcting the effect of UA on AIP, VFA was still an independent related factor of AIP, and VFA increased the risk of atherosclerosis by increased UA. CONCLUSION: T2DM patients have the abnormal distribution of body fat and a high VFA, which was associated with AIP. CI - Copyright(c) Bentham Science Publishers; For any queries, please email at epub@benthamscience.org. FAU - Song, Ping AU - Song P AD - Department of Endocrinology and Metabolism, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China. AD - Institute of Endocrinology and Metabolic Diseases, Shandong Academy of Clinical Medicine, Jinan, Shandong, China. AD - Shandong Clinical Medical Centre of Endocrinology and Metabolism, Jinan, Shandong, China. FAU - Xu, Lan AU - Xu L AD - Department of Endocrinology and Metabolism, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China. AD - Institute of Endocrinology and Metabolic Diseases, Shandong Academy of Clinical Medicine, Jinan, Shandong, China. AD - Shandong Clinical Medical Centre of Endocrinology and Metabolism, Jinan, Shandong, China. FAU - Xu, Jin AU - Xu J AD - Department of Endocrinology and Metabolism, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China. AD - Institute of Endocrinology and Metabolic Diseases, Shandong Academy of Clinical Medicine, Jinan, Shandong, China. AD - Shandong Clinical Medical Centre of Endocrinology and Metabolism, Jinan, Shandong, China. FAU - Zhang, Hai-Qing AU - Zhang HQ AD - Department of Endocrinology and Metabolism, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China. AD - Institute of Endocrinology and Metabolic Diseases, Shandong Academy of Clinical Medicine, Jinan, Shandong, China. AD - Shandong Clinical Medical Centre of Endocrinology and Metabolism, Jinan, Shandong, China. FAU - Yu, Chun-Xiao AU - Yu CX AD - Department of Endocrinology and Metabolism, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China. AD - Institute of Endocrinology and Metabolic Diseases, Shandong Academy of Clinical Medicine, Jinan, Shandong, China. AD - Shandong Clinical Medical Centre of Endocrinology and Metabolism, Jinan, Shandong, China. FAU - Guan, Qing-Bo AU - Guan QB AD - Department of Endocrinology and Metabolism, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China. AD - Institute of Endocrinology and Metabolic Diseases, Shandong Academy of Clinical Medicine, Jinan, Shandong, China. AD - Shandong Clinical Medical Centre of Endocrinology and Metabolism, Jinan, Shandong, China. FAU - Zhao, Meng AU - Zhao M AD - Department of Endocrinology and Metabolism, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China. AD - Institute of Endocrinology and Metabolic Diseases, Shandong Academy of Clinical Medicine, Jinan, Shandong, China. AD - Shandong Clinical Medical Centre of Endocrinology and Metabolism, Jinan, Shandong, China. FAU - Zhang, Xu AU - Zhang X AD - Department of Endocrinology and Metabolism, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China. AD - Institute of Endocrinology and Metabolic Diseases, Shandong Academy of Clinical Medicine, Jinan, Shandong, China. AD - Shandong Clinical Medical Centre of Endocrinology and Metabolism, Jinan, Shandong, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United Arab Emirates TA - Curr Vasc Pharmacol JT - Current vascular pharmacology JID - 101157208 RN - 0 (Biomarkers) RN - 0 (Blood Glucose) RN - 0 (Insulin) RN - 0 (Lipids) SB - IM MH - *Adiposity MH - Aged MH - Atherosclerosis/blood/diagnosis/*etiology/physiopathology MH - Biomarkers/blood MH - Blood Glucose/metabolism MH - Case-Control Studies MH - Cross-Sectional Studies MH - Diabetes Mellitus, Type 2/*blood/complications/diagnosis/*physiopathology MH - Female MH - Humans MH - Insulin/blood MH - Insulin Resistance MH - Intra-Abdominal Fat/*physiopathology MH - Lipids/*blood MH - Male MH - Middle Aged MH - Prognosis MH - Risk Assessment MH - Risk Factors MH - Waist-Hip Ratio OTO - NOTNLM OT - Diabetes mellitus OT - HDL-C OT - T2DM OT - VFA OT - atherogenic index of plasma OT - visceral fat area. EDAT- 2018/01/05 06:00 MHDA- 2019/06/14 06:00 CRDT- 2018/01/05 06:00 PHST- 2017/06/27 00:00 [received] PHST- 2017/12/26 00:00 [revised] PHST- 2017/12/26 00:00 [accepted] PHST- 2018/01/05 06:00 [pubmed] PHST- 2019/06/14 06:00 [medline] PHST- 2018/01/05 06:00 [entrez] AID - CVP-EPUB-87696 [pii] AID - 10.2174/1570161116666180103125456 [doi] PST - ppublish SO - Curr Vasc Pharmacol. 2018;16(6):589-595. doi: 10.2174/1570161116666180103125456.