PMID- 29300005
OWN - NLM
STAT- MEDLINE
DCOM- 20190916
LR  - 20220408
IS  - 2056-676X (Electronic)
IS  - 2056-676X (Linking)
VI  - 4
DP  - 2018 Jan 4
TI  - Food allergy.
PG  - 17098
LID - 10.1038/nrdp.2017.98 [doi]
AB  - Food allergies manifest in a variety of clinical conditions within the 
      gastrointestinal tract, skin and lungs, with the most dramatic and sometimes 
      fatal manifestation being anaphylactic shock. Major progress has been made in 
      basic, translational and clinical research, leading to a better understanding of 
      the underlying immunological mechanisms that lead to the breakdown of clinical 
      and immunological tolerance against food antigens, which can result in either 
      immunoglobulin E (IgE)-mediated reactions or non-IgE-mediated reactions. 
      Lifestyle factors, dietary habits and maternal-neonatal interactions play a 
      pivotal part in triggering the onset of food allergies, including qualitative and 
      quantitative composition of the microbiota. These factors seem to have the 
      greatest influence early in life, an observation that has led to the generation 
      of hypotheses to explain the food allergy epidemic, including the dual-allergen 
      exposure hypothesis. These hypotheses have fuelled research in preventive 
      strategies that seek to establish desensitization to allergens and/or tolerance 
      to allergens in affected individuals. Allergen-nonspecific therapeutic strategies 
      have also been investigated in a number of clinical trials, which will eventually 
      improve the treatment options for patients with food allergy.
FAU - Renz, Harald
AU  - Renz H
AD  - Institute of Laboratory Medicine, Philipps University Marburg, Baldinger Strasse, 
      35043 Marburg, Germany.
FAU - Allen, Katrina J
AU  - Allen KJ
AD  - Murdoch Children's Research Institute and University of Melbourne, Royal 
      Children's Hospital, Melbourne, Australia.
FAU - Sicherer, Scott H
AU  - Sicherer SH
AD  - Department of Pediatrics, Icahn School of Medicine, New York, New York, USA.
FAU - Sampson, Hugh A
AU  - Sampson HA
AD  - Department of Pediatrics, Icahn School of Medicine, New York, New York, USA.
FAU - Lack, Gideon
AU  - Lack G
AD  - Department of Paediatric Allergy, King's College London, London, UK.
FAU - Beyer, Kirsten
AU  - Beyer K
AD  - Charite Universitatsmedizin Berlin, Department of Pediatric Pneumology and 
      Immunology, Berlin, Germany.
FAU - Oettgen, Hans C
AU  - Oettgen HC
AD  - Division of Immunology, Boston Children's Hospital, Boston, Massachusetts, USA.
AD  - Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180104
PL  - England
TA  - Nat Rev Dis Primers
JT  - Nature reviews. Disease primers
JID - 101672103
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Eosinophilic Esophagitis/complications/diagnosis/physiopathology
MH  - Food Hypersensitivity/diet therapy/epidemiology/*physiopathology
MH  - Humans
MH  - Hypersensitivity/*complications
MH  - Immunoglobulin E/analysis/metabolism/*physiology
MH  - Mass Screening/methods
MH  - Proctocolitis/complications/diagnosis/physiopathology
EDAT- 2018/01/05 06:00
MHDA- 2019/09/17 06:00
CRDT- 2018/01/05 06:00
PHST- 2018/01/05 06:00 [entrez]
PHST- 2018/01/05 06:00 [pubmed]
PHST- 2019/09/17 06:00 [medline]
AID - nrdp201798 [pii]
AID - 10.1038/nrdp.2017.98 [doi]
PST - epublish
SO  - Nat Rev Dis Primers. 2018 Jan 4;4:17098. doi: 10.1038/nrdp.2017.98.