PMID- 29301529 OWN - NLM STAT- MEDLINE DCOM- 20190128 LR - 20221207 IS - 1475-2840 (Electronic) IS - 1475-2840 (Linking) VI - 17 IP - 1 DP - 2018 Jan 4 TI - Increased myocardial extracellular volume assessed by cardiovascular magnetic resonance T1 mapping and its determinants in type 2 diabetes mellitus patients with normal myocardial systolic strain. PG - 7 LID - 10.1186/s12933-017-0651-2 [doi] LID - 7 AB - BACKGROUND: Cardiac magnetic resonance (CMR) T1 mapping and tissue-tracking strain analysis are useful quantitative techniques that can characterize myocardial tissue and mechanical alterations, respectively, in patients with early diabetic cardiomyopathy. The purpose of this study was to assess the left ventricular myocardial T1 value, extracellular volume fraction (ECV), and systolic strain in asymptomatic patients with type 2 diabetes mellitus (T2DM) and their underlying relationships with clinical parameters. METHODS: We recruited 50 T2DM patients (mean age: 55 +/- 7 years; 28 males) and 32 sex-, age-and BMI-matched healthy volunteers to undergo contrast-enhanced CMR examinations. The myocardial native T1, post-contrast T1 and ECV values of the left ventricle were measured from T1 and ECV maps acquired using the modified Look-Locker inversion recovery technique. The left ventricular global systolic strain and the strain rates were evaluated using routine cine images and tissue-tracking analysis software. The baseline clinical and biochemical indices were collected before the CMR examination. RESULTS: The myocardial ECV and native T1 values were significantly higher in the diabetic patients than in the controls. (ECV: 27.4 +/- 2.5% vs. 24.6 +/- 2.2%, p < 0.001; native T1: 1026.9 +/- 30.0 ms vs. 1011.8 +/- 26.0 ms, p = 0.022). However, the left ventricular global systolic strain, strain rate, volume, myocardial mass, ejection fraction, and left atrial volume were similar between the diabetic patients and the healthy controls. In the diabetic patients, the native T1 values were independently correlated with the hemoglobin A1c levels (standardized beta = 0.368, p = 0.008). The ECVs were independently associated with the hemoglobin A1c levels (standardized beta = 0.389, p = 0.002), angiotensin-converting enzyme inhibitor (ACEI) treatment (standardized beta = - 0.271, p = 0.025) and HCT values (standardized beta = - 0.397, p = 0.001). CONCLUSIONS: Type 2 diabetes mellitus patients with normal myocardial systolic strain exhibit increased native T1 values and ECVs indicative of myocardial extracellular interstitial expansion, which might be related to poor glycemic control. The amelioration of myocardial interstitial matrix expansion might be associated with ACEI treatment. A valid assessment of the association of glucose control and ACEI treatment with myocardial fibrosis requires notably larger trials. FAU - Cao, Yukun AU - Cao Y AD - Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. FAU - Zeng, Wenjuan AU - Zeng W AD - Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. FAU - Cui, Yue AU - Cui Y AD - Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. FAU - Kong, Xiangchuang AU - Kong X AD - Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. FAU - Wang, Miao AU - Wang M AD - Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. FAU - Yu, Jie AU - Yu J AD - Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. FAU - Zhang, Shan AU - Zhang S AD - Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. FAU - Song, Jing AU - Song J AD - Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. FAU - Yan, Xu AU - Yan X AD - MR Collaboration NE Asia, Siemens Healthcare, Shanghai, 201318, China. FAU - Greiser, Andreas AU - Greiser A AD - Siemens Healthcare, Erlangen, Germany. FAU - Shi, Heshui AU - Shi H AD - Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. heshuishi@hotmail.com. LA - eng GR - 81271570/National Natural Science Foundation of China/International PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180104 PL - England TA - Cardiovasc Diabetol JT - Cardiovascular diabetology JID - 101147637 RN - 0 (Biomarkers) RN - 0 (Glycated Hemoglobin A) RN - 0 (hemoglobin A1c protein, human) SB - IM MH - Adult MH - Aged MH - Asymptomatic Diseases MH - Biomarkers/blood MH - Case-Control Studies MH - Diabetes Mellitus, Type 2/blood/*complications/diagnosis MH - Diabetic Cardiomyopathies/*diagnostic imaging/etiology/physiopathology MH - Female MH - Glycated Hemoglobin/metabolism MH - Humans MH - Hypertrophy, Left Ventricular/*diagnostic imaging/etiology/physiopathology MH - *Magnetic Resonance Imaging MH - Male MH - Middle Aged MH - Observer Variation MH - Predictive Value of Tests MH - Reproducibility of Results MH - Systole MH - Ventricular Function, Left MH - Ventricular Remodeling PMC - PMC5755204 OTO - NOTNLM OT - Cardiac magnetic resonance OT - Diabetic cardiomyopathy OT - Extracellular volume OT - Myocardial strain OT - T1 mapping OT - Tissue tracking EDAT- 2018/01/06 06:00 MHDA- 2019/01/29 06:00 PMCR- 2018/01/04 CRDT- 2018/01/06 06:00 PHST- 2017/09/14 00:00 [received] PHST- 2017/12/23 00:00 [accepted] PHST- 2018/01/06 06:00 [entrez] PHST- 2018/01/06 06:00 [pubmed] PHST- 2019/01/29 06:00 [medline] PHST- 2018/01/04 00:00 [pmc-release] AID - 10.1186/s12933-017-0651-2 [pii] AID - 651 [pii] AID - 10.1186/s12933-017-0651-2 [doi] PST - epublish SO - Cardiovasc Diabetol. 2018 Jan 4;17(1):7. doi: 10.1186/s12933-017-0651-2.