PMID- 29301582 OWN - NLM STAT- MEDLINE DCOM- 20180806 LR - 20221207 IS - 1476-511X (Electronic) IS - 1476-511X (Linking) VI - 17 IP - 1 DP - 2018 Jan 4 TI - Association of polymorphisms in LEPR with type 2 diabetes and related metabolic traits in a Chinese population. PG - 2 LID - 10.1186/s12944-017-0644-x [doi] LID - 2 AB - BACKGROUND: Leptin acts as a mediator of inflammation and energy homeostasis by activating leptin receptor (LEPR). We conducted this study to explore the association of polymorphisms in LEPR with type 2 diabetes mellitus (T2DM) and its related metabolic traits. METHODS: We performed a case-control study to investigate the association of polymorphisms in LEPR with T2DM and related metabolic traits in a Chinese population, with a total of 922 T2DM patients and 1031 nondiabetic subjects. Polymorphisms were genotyped using MassARRAY assay. RESULTS: The G allele of rs1327118 was associated with a decreased risk of T2DM in men (P = 0.044, odds ratio = 0.707, 95% confidence interval = 0.504-0.991) and the G allele of rs3806318 was associated with increased systolic blood pressure (SBP) in men with T2DM. Besides, the women patients carrying the G allele of rs1327118 showed increased SBP and diastolic blood pressure (DBP) levels, but decreased high density lipoprotein cholesterol (HDL-C) level. CONCLUSION: Our results suggest that rs1327118 may be associated with SBP, DBP and HDL-C levels in women with T2DM, and rs3806318 may be associated with T2DM and SBP level in men with T2DM. Further studies with larger sample size or functional experiments focused on exact mechanism are required to verify our observations. FAU - Zhang, Lulu AU - Zhang L AD - School of Public Health, Guangxi Medical University, Nanning, 530021, People's Republic of China. AD - Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, 530021, People's Republic of China. FAU - Qin, Yingfen AU - Qin Y AD - Department of Endocrine, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, People's Republic of China. FAU - Liang, Danyan AU - Liang D AD - Third Affiliated Hospital of Guangxi Medical University, Nanning, 530021, People's Republic of China. FAU - Li, Li AU - Li L AD - Department of Endocrine, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, People's Republic of China. FAU - Liang, Yaojie AU - Liang Y AD - Beihai Center for Disease Prevention and Control, Beihai, 536000, People's Republic of China. FAU - Chen, Lulin AU - Chen L AD - School of Public Health, Guangxi Medical University, Nanning, 530021, People's Republic of China. AD - Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, 530021, People's Republic of China. FAU - Tong, Lei AU - Tong L AD - School of Public Health, Guangxi Medical University, Nanning, 530021, People's Republic of China. AD - Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, 530021, People's Republic of China. FAU - Zhou, Jia AU - Zhou J AD - Department of Endocrine, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, People's Republic of China. FAU - Li, Hong AU - Li H AD - School of General Medicine, Guangxi Medical University, Nanning, 530021, People's Republic of China. hnlihong@gxmu.edu.cn. FAU - Zhang, Haiying AU - Zhang H AD - School of Public Health, Guangxi Medical University, Nanning, 530021, People's Republic of China. zhanghaiying@gxmu.edu.cn. AD - Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, 530021, People's Republic of China. zhanghaiying@gxmu.edu.cn. AD - Guangxi key laboratory for genomic and personalized medicine, Guangxi collaborative innovation center for genomic and personalized medicine, Guangxi Medical University, Nanning, 530021, People's Republic of China. zhanghaiying@gxmu.edu.cn. LA - eng GR - 81760130/National Natural Science Foundation of China/ GR - 81460159/National Natural Science Foundation of China/ GR - 81260145/National Natural Science Foundation of China/ GR - 2016YFC0901200 ; 2016YFC0901205/Important Specific Projects for "Precision Medicine" 2016 National Annual Project/ GR - 201502007/Scientific Research Specific Projects for Public Welfare (Medical)/ PT - Journal Article DEP - 20180104 PL - England TA - Lipids Health Dis JT - Lipids in health and disease JID - 101147696 RN - 0 (Blood Glucose) RN - 0 (Cholesterol, HDL) RN - 0 (LEPR protein, human) RN - 0 (Receptors, Leptin) SB - IM MH - Aged MH - Alleles MH - Asian People MH - Blood Glucose/metabolism MH - Blood Pressure MH - Case-Control Studies MH - Cholesterol, HDL/blood MH - Diabetes Mellitus, Type 2/blood/ethnology/*genetics/pathology MH - Female MH - Gene Expression MH - Gene Frequency MH - *Genotype MH - Humans MH - Male MH - Middle Aged MH - Phenotype MH - *Polymorphism, Single Nucleotide MH - Receptors, Leptin/blood/*genetics MH - Risk Factors MH - Sex Factors PMC - PMC5753482 OTO - NOTNLM OT - Blood pressure OT - LEPR gene OT - Polymorphism OT - Type 2 diabetes mellitus COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: All procedures performed in this study involving human participants were approved by the Ethics Committee of Guangxi Medical University (Nanning, P. R. China). Informed consent was obtained from all subjects. CONSENT FOR PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER'S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. EDAT- 2018/01/06 06:00 MHDA- 2018/08/07 06:00 PMCR- 2018/01/04 CRDT- 2018/01/06 06:00 PHST- 2017/10/31 00:00 [received] PHST- 2017/12/13 00:00 [accepted] PHST- 2018/01/06 06:00 [entrez] PHST- 2018/01/06 06:00 [pubmed] PHST- 2018/08/07 06:00 [medline] PHST- 2018/01/04 00:00 [pmc-release] AID - 10.1186/s12944-017-0644-x [pii] AID - 644 [pii] AID - 10.1186/s12944-017-0644-x [doi] PST - epublish SO - Lipids Health Dis. 2018 Jan 4;17(1):2. doi: 10.1186/s12944-017-0644-x.