PMID- 29302619
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2373-9878 (Print)
IS  - 2373-9878 (Electronic)
IS  - 2373-9878 (Linking)
VI  - 3
IP  - 12
DP  - 2017 Dec 11
TI  - Protein Mimetic and Anticancer Properties of Monocyte-Targeting Peptide 
      Amphiphile Micelles.
PG  - 3273-3282
LID - 10.1021/acsbiomaterials.7b00600 [doi]
AB  - Monocyte chemoattractant protein-1 (MCP-1) stimulates the migration of monocytes 
      to inflammatory sites, leading to the progression of many diseases. Recently, we 
      described a monocyte-targeting peptide amphiphile micelle (MCP-1 PAM) 
      incorporated with the chemokine receptor CCR2 binding motif of MCP-1, which has a 
      high affinity for monocytes in atherosclerotic plaques. We further report here 
      the biomimetic components of MCP-1 PAMs and the influence of the nanoparticle 
      upon binding to monocytes. We report that MCP-1 PAMs have enhanced secondary 
      structure compared to the MCP-1 peptide. As a result, MCP-1 PAMs displayed 
      improved binding and chemoattractant properties to monocytes, which upregulated 
      the inflammatory signaling pathways responsible for monocyte migration. 
      Interestingly, when MCP-1 PAMs were incubated in the presence of prostate cancer 
      cells in vitro, the particle displayed anticancer efficacy by reducing CCR2 
      expression. Given that monocytes play an important role in tumor cell migration 
      and invasion, our results demonstrate that PAMs can improve the native 
      biofunctional properties of the peptide and may be used as an effective inhibitor 
      to prevent chemokine-receptor interactions that promote disease progression.
FAU - Poon, Christopher
AU  - Poon C
AD  - Department of Biomedical Engineering, University of Southern California, 1042 
      Downey Way, Los Angeles, California 90089, United States.
FAU - Chowdhuri, Sampreeti
AU  - Chowdhuri S
AD  - Department of Biomedical Engineering, University of Southern California, 1042 
      Downey Way, Los Angeles, California 90089, United States.
FAU - Kuo, Cheng-Hsiang
AU  - Kuo CH
AD  - Section of Pulmonary and Critical Care, Department of Medicine, University of 
      Chicago, 5841 South Maryland Avenue, Chicago, Illinois 60637, United States.
FAU - Fang, Yun
AU  - Fang Y
AD  - Section of Pulmonary and Critical Care, Department of Medicine, University of 
      Chicago, 5841 South Maryland Avenue, Chicago, Illinois 60637, United States.
FAU - Alenghat, Francis J
AU  - Alenghat FJ
AD  - Section of Cardiology, Department of Medicine, University of Chicago, 5841 South 
      Maryland Avenue, Chicago, Illinois 60637, United States.
FAU - Hyatt, Danielle
AU  - Hyatt D
AD  - Section of Cardiology, Department of Medicine, University of Chicago, 5841 South 
      Maryland Avenue, Chicago, Illinois 60637, United States.
FAU - Kani, Kian
AU  - Kani K
AD  - Lawrence J. Ellison Institute for Transformative Medicine of USC, Keck School of 
      Medicine, University of Southern California, 2250 Alcazar Street, Los Angeles, 
      California 90089, United States.
FAU - Gross, Mitchell E
AU  - Gross ME
AD  - Lawrence J. Ellison Institute for Transformative Medicine of USC, Keck School of 
      Medicine, University of Southern California, 2250 Alcazar Street, Los Angeles, 
      California 90089, United States.
FAU - Chung, Eun Ji
AU  - Chung EJ
AD  - Department of Biomedical Engineering, University of Southern California, 1042 
      Downey Way, Los Angeles, California 90089, United States.
LA  - eng
GR  - K08 HL116600/HL/NHLBI NIH HHS/United States
GR  - R00 HL124279/HL/NHLBI NIH HHS/United States
GR  - R01 HL138223/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20170928
PL  - United States
TA  - ACS Biomater Sci Eng
JT  - ACS biomaterials science & engineering
JID - 101654670
PMC - PMC5749269
MID - NIHMS913627
OTO - NOTNLM
OT  - atherosclerosis
OT  - monocyte
OT  - nanoparticle
OT  - peptide
OT  - peptide amphiphile micelle
OT  - prostate cancer
COIS- Notes The authors declare no competing financial interest.
EDAT- 2018/01/06 06:00
MHDA- 2018/01/06 06:01
PMCR- 2018/01/02
CRDT- 2018/01/06 06:00
PHST- 2018/01/06 06:00 [entrez]
PHST- 2018/01/06 06:00 [pubmed]
PHST- 2018/01/06 06:01 [medline]
PHST- 2018/01/02 00:00 [pmc-release]
AID - 10.1021/acsbiomaterials.7b00600 [doi]
PST - ppublish
SO  - ACS Biomater Sci Eng. 2017 Dec 11;3(12):3273-3282. doi: 
      10.1021/acsbiomaterials.7b00600. Epub 2017 Sep 28.