PMID- 29303151
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20190401
IS  - 1476-5454 (Electronic)
IS  - 0950-222X (Print)
IS  - 0950-222X (Linking)
VI  - 32
IP  - 4
DP  - 2018 Apr
TI  - Swept-source and optical coherence tomography angiography in patients with 
      X-linked retinoschisis.
PG  - 707-715
LID - 10.1038/eye.2017.281 [doi]
AB  - PurposeTo explore the structural features of juvenile X-linked retinoschisis 
      (XLRS) using swept-source-optical coherence tomography (SS-OCT) and optical 
      coherence tomography angiography (OCT-A).DesignRetrospective, observational 
      cross-sectional study.Patients and methodsNine patients (18 eyes) diagnosed with 
      juvenile XLRS were included. SS-OCT and OCT-A were used to evaluate the 
      characteristics of the inner/outer retina and the choroid.ResultsSS-OCT showed 
      that the inner nuclear layer (INL) was the most commonly affected area (16/18 
      eyes; 89%). No significant differences in central macular thickness (CMT) or 
      subfield choroidal thickness (SFCT) were evidenced between eyes (CMT: 364 mum in 
      the right eye vs 320 mum in the left eye; SFCT: 305 vs 307 mum; P=0.895). 
      Best-corrected visual acuity (BCVA) did not correlate with CMT (rs= -0.19; 
      P=0.445) or SFCT (rs=0.06; P=0.795). BCVA was significantly correlated with the 
      following defects: outer plexiform layer (OPL; rs=0.50; P=0.036); external 
      limiting membrane (ELM; rs=0.65; P=0.003); ellipsoid portion of inner segment 
      (EPIS; rs=0.67; P=0.002); and the cone outer segment tips (COST; rs=0.69; 
      P=0.001). Schisis at the INL revealed a spoke-like pattern in the foveal region 
      and a reticular pattern in the parafoveal region on en-face imaging. In cases in 
      which the schisis affected the OPL, multiple polygonal hyporeflective cavities 
      were observed in the foveal region.ConclusionsThe hyporeflective spaces on SS-OCT 
      were primarily located at the INL and OPL. BCVA did not correlate with CMT or 
      SFCT; however, ELM, EPIS, and COST defects were significantly correlated with 
      worse BCVA. There was a positive correlation between age and SFCT.
FAU - Padron-Perez, N
AU  - Padron-Perez N
AD  - Department of Ophthalmology, Bellvitge University Hospital, Barcelona, Spain.
FAU - Catala-Mora, J
AU  - Catala-Mora J
AD  - Department of Ophthalmology, Bellvitge University Hospital, Barcelona, Spain.
AD  - Department of Ophthalmology, Sant Joan de Deu Hospital, Barcelona, Spain.
FAU - Diaz, J
AU  - Diaz J
AD  - Department of Ophthalmology, Sant Joan de Deu Hospital, Barcelona, Spain.
AD  - Department of Ophthalmology, Sant Pau Hospital, Barcelona, Spain.
FAU - Arias, L
AU  - Arias L
AD  - Department of Ophthalmology, Bellvitge University Hospital, Barcelona, Spain.
FAU - Prat, J
AU  - Prat J
AD  - Department of Ophthalmology, Sant Joan de Deu Hospital, Barcelona, Spain.
FAU - Caminal, J M
AU  - Caminal JM
AD  - Department of Ophthalmology, Bellvitge University Hospital, Barcelona, Spain.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20180105
PL  - England
TA  - Eye (Lond)
JT  - Eye (London, England)
JID - 8703986
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Angiography/*methods
MH  - Child
MH  - Cross-Sectional Studies
MH  - *Diagnostic Techniques, Ophthalmological
MH  - Female
MH  - Fovea Centralis/pathology
MH  - Humans
MH  - Male
MH  - Retinoschisis/*diagnostic imaging/pathology/physiopathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Acuity/physiology
MH  - Young Adult
PMC - PMC5898861
COIS- The authors declare no conflict of interest.
EDAT- 2018/01/06 06:00
MHDA- 2018/12/12 06:00
PMCR- 2019/04/01
CRDT- 2018/01/06 06:00
PHST- 2017/04/29 00:00 [received]
PHST- 2017/10/02 00:00 [accepted]
PHST- 2018/01/06 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/01/06 06:00 [entrez]
PHST- 2019/04/01 00:00 [pmc-release]
AID - eye2017281 [pii]
AID - 10.1038/eye.2017.281 [doi]
PST - ppublish
SO  - Eye (Lond). 2018 Apr;32(4):707-715. doi: 10.1038/eye.2017.281. Epub 2018 Jan 5.