PMID- 29305138
OWN - NLM
STAT- MEDLINE
DCOM- 20191114
LR  - 20191114
IS  - 1873-2364 (Electronic)
IS  - 0960-8966 (Linking)
VI  - 28
IP  - 2
DP  - 2018 Feb
TI  - MuSK myasthenia gravis and pregnancy.
PG  - 150-153
LID - S0960-8966(17)31225-7 [pii]
LID - 10.1016/j.nmd.2017.11.014 [doi]
AB  - Muscle specific kinase (MuSK) myasthenia gravis (MG, MuSK-MG) is a rare subgroup 
      of MG affecting mainly women during childbearing years. We investigated the 
      influence of pregnancy in the course of MuSK-MG and pregnancy outcomes in females 
      with MuSK-MG. A multicentre cohort of 17 women with MuSK-MG was studied 
      retrospectively; 13 of them with >/=1 pregnancy. MuSK-MG onset age was 35,4 years; 
      23,0% had other autoimmune disorder; 46,2% were treatment refractory. Thirteen 
      women experienced 27 pregnancies, either after MG onset (group I) (n = 4; 
      maternal age at conception = 29.8 years) or before MG onset (group II) (n = 23; 
      maternal age at conception = 26.2 years). In group I pregnancy occurred in 
      average 9.8 years after the MG onset; it occurred in average 17.0 years before MG 
      in group II. In group I, all were on steroids at time of conception, one on 
      azathioprine and another receiving IVIG regularly. There were mild exacerbations 
      that responded to treatment adjustments. There were no relapses in the 12 months 
      following the delivery. There was no pre-eclampsia, birth defects or stillbirths 
      in either group; 3 miscarriages in group II. One case of neonatal MG was 
      recorded. In this small series, pregnancy did not seem to precipitate MuSK-MG or 
      to have a major influence in the MuSK-MG course, and there was no apparent 
      negative impact in pregnancy outcomes in those where pregnancy followed the MG 
      onset. The weight was lower in the newborn of the group I mothers, although none 
      had low birth weight.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Santos, Ernestina
AU  - Santos E
AD  - Neurology Department, Hospital Santo Antonio, Centro Hospitalar Porto, Porto, 
      Portugal; Unit for Multidisciplinary Research in Biomedicine, Instituto de 
      Ciencias Biomedicas de Abel Salazar, Universidade do Porto, Porto, Portugal. 
      Electronic address: ernestina.santos@gmail.com.
FAU - Braga, Antonio
AU  - Braga A
AD  - Obstetrics Department, Centro Materno-Infantil do Norte, Centro Hospitalar Porto, 
      Porto, Portugal.
FAU - Gabriel, Denis
AU  - Gabriel D
AD  - Neurology Department, Hospital Santo Antonio, Centro Hospitalar Porto, Porto, 
      Portugal.
FAU - Duarte, Sara
AU  - Duarte S
AD  - Neurology Department, Hospital Santo Antonio, Centro Hospitalar Porto, Porto, 
      Portugal.
FAU - Martins da Silva, Ana
AU  - Martins da Silva A
AD  - Neurology Department, Hospital Santo Antonio, Centro Hospitalar Porto, Porto, 
      Portugal; Unit for Multidisciplinary Research in Biomedicine, Instituto de 
      Ciencias Biomedicas de Abel Salazar, Universidade do Porto, Porto, Portugal.
FAU - Matos, Ilda
AU  - Matos I
AD  - Neurology Department, Centro Hospitalar do Nordeste, Mirandela, Portugal.
FAU - Freijo, Marta
AU  - Freijo M
AD  - Neurology Department, Centro Hospitalar do Nordeste, Mirandela, Portugal.
FAU - Martins, Joao
AU  - Martins J
AD  - Neurology Department, Hospital de Pedro Hispano, Matosinhos, Portugal.
FAU - Silveira, Fernando
AU  - Silveira F
AD  - Neurology Department, Hospital Sao Joao, Porto, Portugal.
FAU - Nadais, Goreti
AU  - Nadais G
AD  - Neurology Department, Hospital Sao Joao, Porto, Portugal.
FAU - Sousa, Filipa
AU  - Sousa F
AD  - Neurology Department, Hospital de Braga, Braga, Portugal.
FAU - Fraga, Carla
AU  - Fraga C
AD  - Centro Hospitalar do Vale do Sousa, Penafiel, Portugal.
FAU - Santos Silva, Rosa
AU  - Santos Silva R
AD  - Neurology Department, Centro Hospitalar do Alto Minho, Viana do Castelo, 
      Portugal.
FAU - Lopes, Carlos
AU  - Lopes C
AD  - Instituto de Ciencias Biomedicas Abel Salazar, Universidade do Porto, Porto, 
      Portugal.
FAU - Goncalves, Guilherme
AU  - Goncalves G
AD  - Unit for Multidisciplinary Research in Biomedicine, Instituto de Ciencias 
      Biomedicas de Abel Salazar, Universidade do Porto, Porto, Portugal.
FAU - Pinto, Clara
AU  - Pinto C
AD  - Obstetrics Department, Centro Materno-Infantil do Norte, Centro Hospitalar Porto, 
      Porto, Portugal.
FAU - Sousa Braga, Jorge
AU  - Sousa Braga J
AD  - Obstetrics Department, Centro Materno-Infantil do Norte, Centro Hospitalar Porto, 
      Porto, Portugal.
FAU - Leite, Maria Isabel
AU  - Leite MI
AD  - Nuffield Department of Clinical Neurosciences, Oxford University Hospitals, 
      University of Oxford, Oxford, United Kingdom.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20171128
PL  - England
TA  - Neuromuscul Disord
JT  - Neuromuscular disorders : NMD
JID - 9111470
RN  - 0 (Receptors, Cholinergic)
RN  - EC 2.7.10.1 (MUSK protein, human)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Birth Weight
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Myasthenia Gravis/drug therapy/*epidemiology
MH  - Pregnancy
MH  - Pregnancy Complications/drug therapy/*epidemiology
MH  - Pregnancy Outcome
MH  - Receptor Protein-Tyrosine Kinases
MH  - Receptors, Cholinergic
MH  - Retrospective Studies
OTO - NOTNLM
OT  - MuSK
OT  - MuSK-MG
OT  - Myasthenia gravis
OT  - Neonatal MG
OT  - Pregnancy
EDAT- 2018/01/07 06:00
MHDA- 2019/11/15 06:00
CRDT- 2018/01/07 06:00
PHST- 2017/08/10 00:00 [received]
PHST- 2017/10/19 00:00 [revised]
PHST- 2017/11/21 00:00 [accepted]
PHST- 2018/01/07 06:00 [pubmed]
PHST- 2019/11/15 06:00 [medline]
PHST- 2018/01/07 06:00 [entrez]
AID - S0960-8966(17)31225-7 [pii]
AID - 10.1016/j.nmd.2017.11.014 [doi]
PST - ppublish
SO  - Neuromuscul Disord. 2018 Feb;28(2):150-153. doi: 10.1016/j.nmd.2017.11.014. Epub 
      2017 Nov 28.