PMID- 29305739 OWN - NLM STAT- MEDLINE DCOM- 20190306 LR - 20190306 IS - 1875-8312 (Electronic) IS - 1569-5794 (Linking) VI - 34 IP - 6 DP - 2018 Jun TI - Quantitative inversion time prescription for myocardial late gadolinium enhancement using T1-mapping-based synthetic inversion recovery imaging: reducing subjectivity in the estimation of inversion time. PG - 921-929 LID - 10.1007/s10554-017-1294-9 [doi] AB - To develop a quantitative T1-mapping-based synthetic inversion recovery (IR(synth)) approach to calculate the optimal inversion time (TI(0)) for late gadolinium enhancement (LGE) imaging. Prospectively enrolled patients (n = 130, 58 +/- 16 years) underwent cardiac MRI on a 1.5T system including Look-Locker TI-scout (LL), modified LL IR (MOLLI)-based T1-mapping, and LGE acquisitions. Patients were randomized into two groups: LL group (TI-scout followed T1-mapping) or MOLLI group (T1-mapping followed TI-scout). In both groups, the second acquisition was used to determine the TI(0) for LGE. IR(synth) images were generated from T1-maps between TI = 200-400 ms in 5 ms increments. Image quality was rated on a 3-point scale and the remote/background signal intensity ratio (SIR) was calculated. In the LL group (n = 53), the TI-scout-based TI(0) was significantly shorter compared to IR(synth) [230 ms (219-242) vs. 280 ms (263-297), P < 0.0001]. The TI(0) used for LGE was set 30-40 ms longer [261 ms (247-276), P < 0.0001] than the TI-scout-based TI(0), resulting in a TI(0) ~ 20 ms shorter than what was obtained by IR(synth) (P = 0.0156). In the MOLLI group (n = 63), IR(synth)-based TI(0) was significantly longer than the TI-scout-based TI(0) [298 ms (262-334) vs. 242 ms (217-267), P = 0.0313]. The quality of myocardial nulling was rated higher [2.4 (2.2-2.5) vs. 2.0 (1.8-2.1), P = 0.0042] and the remote/background SIR was found to be more optimal (1.6 [1.1-2.1] vs. 2.6 [1.8-3.3], P = 0.0256) in the MOLLI group. T1-based IR(synth) selects TI(0) for LGE more accurately than conventional TI-scout imaging. IR(synth) improves TI(0) selection by providing excellent visualization of the representative image contrast for LGE images, reducing operator dependence in LGE acquisition. FAU - Gassenmaier, Sebastian AU - Gassenmaier S AD - Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, 25 Courtenay Dr, MSC 226, Charleston, SC, 29425, USA. AD - Department of Radiology, University Hospital, Ludwig-Maximilians-University, Munich, Germany. FAU - van der Geest, Rob J AU - van der Geest RJ AD - Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands. FAU - Schoepf, U Joseph AU - Schoepf UJ AUID- ORCID: 0000-0002-6164-5641 AD - Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, 25 Courtenay Dr, MSC 226, Charleston, SC, 29425, USA. schoepf@musc.edu. FAU - Suranyi, Pal AU - Suranyi P AD - Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, 25 Courtenay Dr, MSC 226, Charleston, SC, 29425, USA. FAU - Rehwald, Wolfgang G AU - Rehwald WG AD - Siemens Medical Solutions, Chicago, IL, USA. AD - Cardiovascular Magnetic Resonance Center, Duke University Medical Center, Durham, USA. FAU - De Cecco, Carlo N AU - De Cecco CN AD - Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, 25 Courtenay Dr, MSC 226, Charleston, SC, 29425, USA. FAU - Mastrodicasa, Domenico AU - Mastrodicasa D AD - Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, 25 Courtenay Dr, MSC 226, Charleston, SC, 29425, USA. AD - Department of Neuroscience and Imaging, Section of Diagnostic Imaging and Therapy - Radiology Division, "G. d'Annunzio" University, Chieti, Italy. FAU - Albrecht, Moritz H AU - Albrecht MH AD - Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, 25 Courtenay Dr, MSC 226, Charleston, SC, 29425, USA. AD - Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt, Germany. FAU - De Santis, Domenico AU - De Santis D AD - Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, 25 Courtenay Dr, MSC 226, Charleston, SC, 29425, USA. AD - Department of Radiological Sciences, Oncology and Pathology, University of Rome "Sapienza", Rome, Italy. FAU - Lesslie, Virginia W AU - Lesslie VW AD - Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, 25 Courtenay Dr, MSC 226, Charleston, SC, 29425, USA. FAU - Ruzsics, Balazs AU - Ruzsics B AD - Department of Cardiology, Royal Liverpool and Broadgreen University Hospital, Liverpool, UK. FAU - Varga-Szemes, Akos AU - Varga-Szemes A AD - Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, 25 Courtenay Dr, MSC 226, Charleston, SC, 29425, USA. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20180105 PL - United States TA - Int J Cardiovasc Imaging JT - The international journal of cardiovascular imaging JID - 100969716 RN - 0 (Contrast Media) RN - AU0V1LM3JT (Gadolinium) SB - IM MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - Cardiac Imaging Techniques/methods/standards MH - Chronic Disease MH - Contrast Media MH - Female MH - Gadolinium MH - Heart/*diagnostic imaging MH - Humans MH - Magnetic Resonance Imaging/*methods/standards MH - Male MH - Middle Aged MH - Myocardium/*pathology MH - Predictive Value of Tests MH - Prospective Studies MH - Reproducibility of Results MH - Time Factors MH - Young Adult OTO - NOTNLM OT - Cardiovascular magnetic resonance imaging OT - Inversion recovery OT - Inversion time OT - Late gadolinium enhancement OT - Look-Locker OT - T1-mapping EDAT- 2018/01/07 06:00 MHDA- 2019/03/07 06:00 CRDT- 2018/01/07 06:00 PHST- 2017/10/20 00:00 [received] PHST- 2017/12/19 00:00 [accepted] PHST- 2018/01/07 06:00 [pubmed] PHST- 2019/03/07 06:00 [medline] PHST- 2018/01/07 06:00 [entrez] AID - 10.1007/s10554-017-1294-9 [pii] AID - 10.1007/s10554-017-1294-9 [doi] PST - ppublish SO - Int J Cardiovasc Imaging. 2018 Jun;34(6):921-929. doi: 10.1007/s10554-017-1294-9. Epub 2018 Jan 5.