PMID- 29305826
OWN - NLM
STAT- MEDLINE
DCOM- 20181106
LR  - 20181113
IS  - 1720-8386 (Electronic)
IS  - 0391-4097 (Linking)
VI  - 41
IP  - 8
DP  - 2018 Aug
TI  - Hepcidin, soluble transferrin receptor and IL-6 levels in obese children and 
      adolescents with and without type 2 diabetes mellitus/impaired glucose tolerance 
      and their association with obstructive sleep apnea.
PG  - 969-975
LID - 10.1007/s40618-017-0823-7 [doi]
AB  - PURPOSE: Obesity, type 2 diabetes mellitus (T2DM), and obstructive sleep apnea 
      (OSA) are associated with chronic low-grade inflammation. Iron metabolism is 
      linked with insulin-resistant states and with OSA in adults. The association of 
      body iron status with T2DM in children remains undefined. We aimed to evaluate 
      plasma interleukin-6 (IL-6), hepcidin, and soluble transferrin receptor (sTfR) 
      levels in obese patients with T2DM or impaired glucose tolerance (IGT) and in 
      those without, and the contribution of OSA to their levels. METHODS: In this 
      cross-sectional study, obese children and adolescents with and without T2DM/IGT 
      underwent overnight polysomnography. Fasting plasma concentrations of IL-6, 
      hepcidin, and sTfR were measured and evaluated according to glycemic status 
      (T2DM/IGT and normal glucose tolerance) and the presence of OSA. RESULTS: Ten 
      patients with T2DM (age 15.9 +/- 3.6 years), 8 with IGT (age 13.1 +/- 2.5 years) and 
      20 subjects with normal glucose tolerance matched for body mass index standard 
      deviation score (age 12.6 +/- 3.3 years) were studied. Sleep measures or IL-6, 
      hepcidin, and sTfR levels were not significantly different between the group with 
      T2DM/IGT vs. the control group. No significant differences were found in hepcidin 
      or sTfR levels between patients with OSA and those without. However, patients 
      with OSA showed higher plasma IL-6 values compared with those without 
      (4.56 +/- 2.92 vs. 2.83 +/- 1.54 pg/ml, P = 0.025), and the highest values were 
      evident in patients affected by both T2DM/IGT and OSA. CONCLUSIONS: Higher IL-6 
      levels were associated with both glycemic status and OSA. No differences in body 
      iron regulator levels were found in obese patients with T2DM/IGT compared to 
      those without or in those with OSA compared to those without. Further 
      longitudinal studies in larger population samples are warranted.
FAU - Shalitin, S
AU  - Shalitin S
AD  - The Jesse Z. and Lea Shafer, Institute for Endocrinology and Diabetes, National 
      Center for Childhood Diabetes, Schneider Children's Medical Center of Israel, 14 
      Kaplan St., 49202, Petach Tikva, Israel. shalitin@netvision.net.il.
AD  - Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. 
      shalitin@netvision.net.il.
FAU - Deutsch, V
AU  - Deutsch V
AD  - The Hematology Institute, Tel Aviv Medical Center, Tel Aviv, Israel.
AD  - Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Tauman, R
AU  - Tauman R
AD  - Pediatric Sleep Laboratory, Dana Children's Hospital, Tel Aviv Medical Center, 
      Tel Aviv, Israel.
AD  - Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
LA  - eng
PT  - Journal Article
DEP - 20180105
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
RN  - 0 (Biomarkers)
RN  - 0 (Hepcidins)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (Receptors, Transferrin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/*blood
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Child
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Female
MH  - Follow-Up Studies
MH  - Glucose Intolerance/*blood/complications
MH  - Glucose Tolerance Test
MH  - Hepcidins/*blood
MH  - Humans
MH  - Insulin Resistance
MH  - Interleukin-6/*blood
MH  - Male
MH  - Obesity/*blood/complications
MH  - Pilot Projects
MH  - Polysomnography
MH  - Prognosis
MH  - Prospective Studies
MH  - Receptors, Transferrin/*blood
MH  - Risk Factors
MH  - Sleep Apnea, Obstructive/*blood/etiology
MH  - Young Adult
OTO - NOTNLM
OT  - Hepcidin
OT  - IL-6
OT  - Impaired glucose tolerance
OT  - Obesity
OT  - Obstructive sleep apnea
OT  - Soluble transferrin receptor (sTfR)
OT  - Type 2 diabetes mellitus
EDAT- 2018/01/07 06:00
MHDA- 2018/11/07 06:00
CRDT- 2018/01/07 06:00
PHST- 2017/11/14 00:00 [received]
PHST- 2017/12/29 00:00 [accepted]
PHST- 2018/01/07 06:00 [pubmed]
PHST- 2018/11/07 06:00 [medline]
PHST- 2018/01/07 06:00 [entrez]
AID - 10.1007/s40618-017-0823-7 [pii]
AID - 10.1007/s40618-017-0823-7 [doi]
PST - ppublish
SO  - J Endocrinol Invest. 2018 Aug;41(8):969-975. doi: 10.1007/s40618-017-0823-7. Epub 
      2018 Jan 5.