PMID- 29305843
OWN - NLM
STAT- MEDLINE
DCOM- 20180829
LR  - 20180829
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 479
DP  - 2018 Apr
TI  - Circulating microparticles levels are increased in patients with diabetic kidney 
      disease: A case-control research.
PG  - 48-55
LID - S0009-8981(17)30548-X [pii]
LID - 10.1016/j.cca.2017.12.048 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is associated with chronic lowgrade 
      inflammation. Microparticles (MPs) are extracellular microvesicles released 
      during apoptosis and cellular activation. The MP's pro-coagulant and 
      pro-inflammatory activities are involved in endothelial dysfunction observed in 
      T2DM patients. This study aimed to evaluate the circulating MPs profile in T2DM 
      patients with diabetic kidney disease (DKD) and correlate it with clinical and 
      laboratorial parameters. METHODS: MPs derived from platelets (PMPs), leukocytes 
      (LMPs), endothelial cells (EMPs), and expressing tissue factor (TFMPs) were 
      measured by flow cytometry, in plasma of 39 DKD patients and 30 non-diabetic 
      controls. RESULTS: We observed higher PMPs, LMPs, EMPs, and TFMPs (all p<0.0001) 
      levels in case group as compared to controls. For patients with DKD, circulating 
      MPs levels were influenced by gender, but not by obesity status nor by T2DM 
      onset. Fasting glucose and 25-hydroxyvitamin D levels showed correlation with 
      circulating MPs levels in both groups. CONCLUSIONS: These results suggest that 
      type 2 diabetes mellitus patients with DKD presented higher circulating MPs 
      levels - PMPs, LMPs, EMPs, and TFMPs - which correlated with metabolic 
      alterations.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Rodrigues, Kathryna Fontana
AU  - Rodrigues KF
AD  - Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo 
      Horizonte, Minas Gerais, Brazil.
FAU - Pietrani, Nathalia Teixeira
AU  - Pietrani NT
AD  - Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo 
      Horizonte, Minas Gerais, Brazil.
FAU - Fernandes, Ana Paula
AU  - Fernandes AP
AD  - Faculdade de Farmacia, Universidade Federal de Minas Gerais, Belo Horizonte, 
      Minas Gerais, Brazil.
FAU - Bosco, Adriana Aparecida
AU  - Bosco AA
AD  - Instituto de Ensino e Pesquisa, Santa Casa de Belo Horizonte, Belo Horizonte, 
      Minas Gerais, Brazil.
FAU - de Sousa, Maira Candida Rodrigues
AU  - de Sousa MCR
AD  - Faculdade de Farmacia, Universidade Federal de Minas Gerais, Belo Horizonte, 
      Minas Gerais, Brazil.
FAU - de Fatima Oliveira Silva, Ieda
AU  - de Fatima Oliveira Silva I
AD  - Faculdade de Farmacia, Universidade Federal de Minas Gerais, Belo Horizonte, 
      Minas Gerais, Brazil. Electronic address: iedafos@farmacia.ufmg.br.
FAU - Silveira, Josianne Nicacio
AU  - Silveira JN
AD  - Faculdade de Farmacia, Universidade Federal de Minas Gerais, Belo Horizonte, 
      Minas Gerais, Brazil. Electronic address: nicacio@farmacia.ufmg.br.
FAU - Campos, Fernanda Magalhaes Freire
AU  - Campos FMF
AD  - Faculdade de Farmacia, Universidade Federal de Minas Gerais, Belo Horizonte, 
      Minas Gerais, Brazil.
FAU - Gomes, Karina Braga
AU  - Gomes KB
AD  - Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo 
      Horizonte, Minas Gerais, Brazil; Faculdade de Farmacia, Universidade Federal de 
      Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address: 
      karina@coltec.ufmg.br.
LA  - eng
PT  - Journal Article
DEP - 20180103
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
SB  - IM
MH  - Case-Control Studies
MH  - Cell-Derived Microparticles/*chemistry
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood/diagnosis
MH  - Diabetic Nephropathies/*blood/diagnosis
MH  - Female
MH  - Humans
MH  - Kidney Diseases/*blood/diagnosis
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - Diabetic kidney disease
OT  - Inflammation
OT  - Microparticles
OT  - Obesity
OT  - Type 2 diabetes mellitus
OT  - Vitamin D
EDAT- 2018/01/07 06:00
MHDA- 2018/08/30 06:00
CRDT- 2018/01/07 06:00
PHST- 2017/10/07 00:00 [received]
PHST- 2017/12/30 00:00 [revised]
PHST- 2017/12/30 00:00 [accepted]
PHST- 2018/01/07 06:00 [pubmed]
PHST- 2018/08/30 06:00 [medline]
PHST- 2018/01/07 06:00 [entrez]
AID - S0009-8981(17)30548-X [pii]
AID - 10.1016/j.cca.2017.12.048 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2018 Apr;479:48-55. doi: 10.1016/j.cca.2017.12.048. Epub 2018 Jan 
      3.