PMID- 29306403
OWN - NLM
STAT- MEDLINE
DCOM- 20190927
LR  - 20190927
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Linking)
VI  - 315
DP  - 2018 Feb 15
TI  - Serum titers of autoantibodies against alpha-synuclein and tau in child- and 
      adulthood.
PG  - 33-39
LID - S0165-5728(17)30445-9 [pii]
LID - 10.1016/j.jneuroim.2017.12.003 [doi]
AB  - Autoreactive antibodies against the proteins alpha-synuclein (alpha-syn) and tau are 
      detectable in body fluids of both healthy and diseased elderly people. However, 
      nothing is known about their presence or titers in children. To close this gap 
      and to characterize their temporary expression levels, we used ELISA techniques 
      to investigate the serum titers of alpha-syn and tau reactive autoantibodies in 37 
      and 32 adults and 37 and 31 children, respectively. Most serum samples from the 
      children exhibited both antibody types and interestingly, the levels were similar 
      to those observed in the adult serum samples. Furthermore, sex-specific analysis 
      revealed significantly increased alpha-syn reactive autoantibody titers in female 
      children. The presence of alpha-syn and tau reactive autoantibodies in early 
      childhood indicates that both immunoglobulins belong to the pool of naturally 
      occurring autoantibodies (nAbs), as their antigen-independent synthesis from 
      birth is a crucial characteristic. Due to their general participation in the 
      maintenance of the physiological homeostasis, we hypothesize that both 
      investigated nAbs are involved in the metabolic regulation of their specific 
      antigen. Therefore, they may be a part of a mechanism that already exists in the 
      innate immunological repertoire to provide protection from pathologies caused by 
      dysregulated alpha-syn and tau metabolisms.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Kuhn, Isabell
AU  - Kuhn I
AD  - Department of Neurology, Philipps-University Marburg, Baldingerstrasse, 35043 
      Marburg, Germany.
FAU - Rogosch, Tobias
AU  - Rogosch T
AD  - Children's Hospital, Philipps-University Marburg, Baldingerstrasse, 35043 
      Marburg, Germany; CSL Behring, Clinical Development, Emil-von-Behring Str. 76, 
      35041 Marburg, Germany.
FAU - Schindler, Theresa I
AU  - Schindler TI
AD  - Children's Hospital, Philipps-University Marburg, Baldingerstrasse, 35043 
      Marburg, Germany.
FAU - Tackenberg, Bjorn
AU  - Tackenberg B
AD  - Department of Neurology, Philipps-University Marburg, Baldingerstrasse, 35043 
      Marburg, Germany.
FAU - Zemlin, Michael
AU  - Zemlin M
AD  - Saarland University, Department of General Pediatrics and Neonatology, Kirrberger 
      Str. 100, 66421 Homburg/Saar, Germany.
FAU - Maier, Rolf F
AU  - Maier RF
AD  - Children's Hospital, Philipps-University Marburg, Baldingerstrasse, 35043 
      Marburg, Germany.
FAU - Dodel, Richard
AU  - Dodel R
AD  - Department of Neurology, Philipps-University Marburg, Baldingerstrasse, 35043 
      Marburg, Germany; Chair of Geriatrics, University Hospital Essen, University 
      Duisburg-Essen, Germaniastrasse 1-3, 45356 Essen, Germany. Electronic address: 
      richard.dodel@uk-essen.de.
FAU - Kronimus, Yannick
AU  - Kronimus Y
AD  - Department of Neurology, Philipps-University Marburg, Baldingerstrasse, 35043 
      Marburg, Germany; Chair of Geriatrics, University Hospital Essen, University 
      Duisburg-Essen, Germaniastrasse 1-3, 45356 Essen, Germany.
LA  - eng
PT  - Journal Article
DEP - 20171211
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Autoantibodies)
RN  - 0 (Autoantigens)
RN  - 0 (MAPT protein, human)
RN  - 0 (alpha-Synuclein)
RN  - 0 (tau Proteins)
SB  - IM
MH  - Adolescent
MH  - Aged
MH  - Autoantibodies/*blood/*immunology
MH  - Autoantigens/immunology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Sex Characteristics
MH  - alpha-Synuclein/*immunology
MH  - tau Proteins/*immunology
EDAT- 2018/01/08 06:00
MHDA- 2019/09/29 06:00
CRDT- 2018/01/08 06:00
PHST- 2017/10/12 00:00 [received]
PHST- 2017/12/04 00:00 [revised]
PHST- 2017/12/07 00:00 [accepted]
PHST- 2018/01/08 06:00 [entrez]
PHST- 2018/01/08 06:00 [pubmed]
PHST- 2019/09/29 06:00 [medline]
AID - S0165-5728(17)30445-9 [pii]
AID - 10.1016/j.jneuroim.2017.12.003 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2018 Feb 15;315:33-39. doi: 10.1016/j.jneuroim.2017.12.003. Epub 
      2017 Dec 11.