PMID- 29306404
OWN - NLM
STAT- MEDLINE
DCOM- 20190927
LR  - 20190927
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Linking)
VI  - 315
DP  - 2018 Feb 15
TI  - Cerebrospinal fluid pentraxin 3 and CD40 ligand in anti-N-menthyl-d-aspartate 
      receptor encephalitis.
PG  - 40-44
LID - S0165-5728(17)30177-7 [pii]
LID - 10.1016/j.jneuroim.2017.11.016 [doi]
AB  - Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder 
      of the central nervous system whose pathogenesis involves interleukin (IL)-6 and 
      IL-17A. We examined the correlations between CSF concentrations of the 
      acute-phase protein pentraxin 3 (PTX3), the chronic inflammatory mediator CD40L, 
      IL-6, and IL-17A in anti-NMDAR encephalitis, and the impact on clinical outcome. 
      PTX3, CD40L, IL-6, and IL-17A were significantly higher in the CSF of patients 
      with anti-NMDAR encephalitis than in controls. Within the former, PTX3 levels 
      correlated positively with IL-6 and the mRS, and CD40L levels with IL-17A and the 
      mRS. Higher PTX3 and CD40L levels may reflect the underlying neuroinflammation.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Liu, Baozhu
AU  - Liu B
AD  - Department of Neurology, Nanfang Hospital, Southern Medical University, 
      Guangzhou, China.
FAU - Ai, Peiying
AU  - Ai P
AD  - Department of Neurology, Nanfang Hospital, Southern Medical University, 
      Guangzhou, China.
FAU - Zheng, Dong
AU  - Zheng D
AD  - Department of Neurology, Guangzhou Brain Hospital, China.
FAU - Jiang, Ying
AU  - Jiang Y
AD  - Department of Neurology, The third hospital affiliated to Sun Yat-sen University, 
      China.
FAU - Liu, Xiaojia
AU  - Liu X
AD  - Department of Neurology, Nanfang Hospital, Southern Medical University, 
      Guangzhou, China.
FAU - Pan, Suyue
AU  - Pan S
AD  - Department of Neurology, Nanfang Hospital, Southern Medical University, 
      Guangzhou, China.
FAU - Wang, Honghao
AU  - Wang H
AD  - Department of Neurology, Nanfang Hospital, Southern Medical University, 
      Guangzhou, China. Electronic address: wang_whh@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171202
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Biomarkers)
RN  - 0 (Serum Amyloid P-Component)
RN  - 147205-72-9 (CD40 Ligand)
RN  - 148591-49-5 (PTX3 protein)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Anti-N-Methyl-D-Aspartate Receptor Encephalitis/*cerebrospinal fluid
MH  - Biomarkers/*cerebrospinal fluid
MH  - C-Reactive Protein/*cerebrospinal fluid
MH  - CD40 Ligand/*cerebrospinal fluid
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Serum Amyloid P-Component/*cerebrospinal fluid
OTO - NOTNLM
OT  - Anti-NMDAR encephalitis
OT  - CD40L
OT  - Cerebrospinal fluid
OT  - Cytokine
OT  - Inflammation
OT  - PTX3
EDAT- 2018/01/08 06:00
MHDA- 2019/09/29 06:00
CRDT- 2018/01/08 06:00
PHST- 2017/04/28 00:00 [received]
PHST- 2017/11/17 00:00 [revised]
PHST- 2017/11/27 00:00 [accepted]
PHST- 2018/01/08 06:00 [entrez]
PHST- 2018/01/08 06:00 [pubmed]
PHST- 2019/09/29 06:00 [medline]
AID - S0165-5728(17)30177-7 [pii]
AID - 10.1016/j.jneuroim.2017.11.016 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2018 Feb 15;315:40-44. doi: 10.1016/j.jneuroim.2017.11.016. Epub 
      2017 Dec 2.