PMID- 29306772
OWN - NLM
STAT- MEDLINE
DCOM- 20181231
LR  - 20221207
IS  - 1873-3360 (Electronic)
IS  - 0306-4530 (Linking)
VI  - 89
DP  - 2018 Mar
TI  - Interaction between BDNF and TNF-alpha genes in schizophrenia.
PG  - 1-6
LID - S0306-4530(17)31378-1 [pii]
LID - 10.1016/j.psyneuen.2017.12.024 [doi]
AB  - OBJECTIVE: Our recent work reported that tumor necrosis factor-alpha (TNF-alpha) is 
      negatively correlated with brain-derived neurotrophic factor (BDNF) in patients 
      with schizophrenia. A previous study has shown that TNF-alpha could regulate the 
      extracellular secretion of BDNF. Therefore, we hypothesized that the TNF-alpha gene 
      (TNF-alpha) may interact with the BDNF gene (BDNF) to influence schizophrenia risk. 
      METHODS: We recruited 694 patients with schizophrenia from three mental hospitals 
      in Eastern China and 725 healthy controls. The Positive and Negative Syndrome 
      Scale (PANSS) was employed to evaluate symptom severity. The Repeatable Battery 
      for the Assessment of Neuropsychological Status (RBANS) was performed to assess 
      cognitive function. The SNPs rs6265 in BDNF and rs1799964 in TNF-alpha were 
      genotyped. RESULTS: There were no significant differences in allele and genotype 
      frequencies in either rs6265 or rs1799964 between the case and control groups. A 
      significant association of rs6265 AA + AG x rs1799964 CC + CT with schizophrenia 
      was observed (OR = 1.14, 95%CI: 1.02-1.27; P = .02). There were significant 
      differences in the RBANS attention and total scores between the patients with 
      rs6265A and rs1799964C alleles and those without these two alleles (P = .03 and 
      P = .03 after Bonferroni correction, respectively). CONCLUSION: Our findings 
      provided preliminary evidence that the interaction of BDNF and TNF-alpha may confer 
      susceptibility to schizophrenia and cognitive dysfunction.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Zhang, Yi
AU  - Zhang Y
AD  - Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong 
      University School of Medicine, Shanghai, China.
FAU - Fang, Xinyu
AU  - Fang X
AD  - Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong 
      University School of Medicine, Shanghai, China.
FAU - Fan, Weixing
AU  - Fan W
AD  - Department of Psychiatry, Jinhua Second Hospital, Jinhua, Zhejiang, China.
FAU - Tang, Wei
AU  - Tang W
AD  - Department of Psychiatry, Wenzhou Kangning Hospital, Wenzhou, Zhejiang, China.
FAU - Cai, Jun
AU  - Cai J
AD  - Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong 
      University School of Medicine, Shanghai, China.
FAU - Song, Lisheng
AU  - Song L
AD  - Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong 
      University School of Medicine, Shanghai, China.
FAU - Zhang, Chen
AU  - Zhang C
AD  - Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong 
      University School of Medicine, Shanghai, China. Electronic address: 
      zhangchen645@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171229
PL  - England
TA  - Psychoneuroendocrinology
JT  - Psychoneuroendocrinology
JID - 7612148
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Asian People/genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - China
MH  - Cognition/physiology
MH  - Cognitive Dysfunction
MH  - Ethnicity/genetics
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genetic Predisposition to Disease/genetics
MH  - Hippocampus/metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Risk Factors
MH  - Schizophrenia/*genetics/physiopathology
MH  - Tumor Necrosis Factor-alpha/*genetics
OTO - NOTNLM
OT  - BDNF
OT  - Cognitive function
OT  - Interaction
OT  - Schizophrenia
OT  - TNF-alpha
EDAT- 2018/01/08 06:00
MHDA- 2019/01/01 06:00
CRDT- 2018/01/08 06:00
PHST- 2017/09/23 00:00 [received]
PHST- 2017/12/04 00:00 [revised]
PHST- 2017/12/28 00:00 [accepted]
PHST- 2018/01/08 06:00 [pubmed]
PHST- 2019/01/01 06:00 [medline]
PHST- 2018/01/08 06:00 [entrez]
AID - S0306-4530(17)31378-1 [pii]
AID - 10.1016/j.psyneuen.2017.12.024 [doi]
PST - ppublish
SO  - Psychoneuroendocrinology. 2018 Mar;89:1-6. doi: 10.1016/j.psyneuen.2017.12.024. 
      Epub 2017 Dec 29.