PMID- 29306934
OWN - NLM
STAT- MEDLINE
DCOM- 20181023
LR  - 20181023
IS  - 2191-0200 (Electronic)
IS  - 0334-1763 (Linking)
VI  - 29
IP  - 5
DP  - 2018 Jul 26
TI  - Gliotransmitters and cytokines in the control of blood-brain barrier 
      permeability.
PG  - 567-591
LID - 10.1515/revneuro-2017-0092 [doi]
AB  - The contribution of astrocytes and microglia to the regulation of neuroplasticity 
      or neurovascular unit (NVU) is based on the coordinated secretion of 
      gliotransmitters and cytokines and the release and uptake of metabolites. 
      Blood-brain barrier (BBB) integrity and angiogenesis are influenced by 
      perivascular cells contacting with the abluminal side of brain microvessel 
      endothelial cells (pericytes, astrocytes) or by immune cells existing (microglia) 
      or invading the NVU (macrophages) under pathologic conditions. The release of 
      gliotransmitters or cytokines by activated astroglial and microglial cells is 
      provided by distinct mechanisms, affects intercellular communication, and results 
      in the establishment of microenvironment controlling BBB permeability and 
      neuroinflammation. Glial glutamate transporters and connexin and pannexin 
      hemichannels working in the tight functional coupling with the purinergic system 
      serve as promising molecular targets for manipulating the intercellular 
      communications that control BBB permeability in brain pathologies associated with 
      excessive angiogenesis, cerebrovascular remodeling, and BBB-mediated 
      neuroinflammation. Substantial progress in deciphering the molecular mechanisms 
      underlying the (patho)physiology of perivascular glia provides promising 
      approaches to novel clinically relevant therapies for brain disorders. The 
      present review summarizes the current understandings on the secretory machinery 
      expressed in glial cells (glutamate transporters, connexin and pannexin 
      hemichannels, exocytosis mechanisms, membrane-derived microvesicles, and 
      inflammasomes) and the role of secreted gliotransmitters and cytokines in the 
      regulation of NVU and BBB permeability in (patho)physiologic conditions.
FAU - Osipova, Elena D
AU  - Osipova ED
AD  - Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State 
      Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk 660022, 
      Russia.
AD  - Interdisciplinary Center of Critical Technologies in Medicine, Department of 
      Physiology of Humans and Animals, Saratov State University named after N.G. 
      Chernyshevsky, Saratov 410012, Russia.
FAU - Semyachkina-Glushkovskaya, Oxana V
AU  - Semyachkina-Glushkovskaya OV
AD  - Interdisciplinary Center of Critical Technologies in Medicine, Department of 
      Physiology of Humans and Animals, Saratov State University named after N.G. 
      Chernyshevsky, Saratov 410012, Russia.
FAU - Morgun, Andrey V
AU  - Morgun AV
AD  - Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State 
      Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk 660022, 
      Russia.
AD  - Interdisciplinary Center of Critical Technologies in Medicine, Department of 
      Physiology of Humans and Animals, Saratov State University named after N.G. 
      Chernyshevsky, Saratov 410012, Russia.
FAU - Pisareva, Natalia V
AU  - Pisareva NV
AD  - Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State 
      Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk 660022, 
      Russia.
AD  - Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, 
      Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, 
      Krasnoyarsk 660022, Russia.
FAU - Malinovskaya, Natalia A
AU  - Malinovskaya NA
AD  - Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State 
      Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk 660022, 
      Russia.
AD  - Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, 
      Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, 
      Krasnoyarsk 660022, Russia.
FAU - Boitsova, Elizaveta B
AU  - Boitsova EB
AD  - Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State 
      Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk 660022, 
      Russia.
AD  - Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, 
      Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, 
      Krasnoyarsk 660022, Russia.
FAU - Pozhilenkova, Elena A
AU  - Pozhilenkova EA
AD  - Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State 
      Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk 660022, 
      Russia.
AD  - Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, 
      Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, 
      Krasnoyarsk 660022, Russia.
FAU - Belova, Olga A
AU  - Belova OA
AD  - Department of Traumatology, Orthopedics and Neurosurgery, Krasnoyarsk State 
      Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk 660022, 
      Russia.
FAU - Salmin, Vladimir V
AU  - Salmin VV
AD  - Interdisciplinary Center of Critical Technologies in Medicine, Department of 
      Physiology of Humans and Animals, Saratov State University named after N.G. 
      Chernyshevsky, Saratov 410012, Russia.
AD  - Department of Medical and Biological Physics, Krasnoyarsk State Medical 
      University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk 660022, Russia.
FAU - Taranushenko, Tatiana E
AU  - Taranushenko TE
AD  - Department of Pediatrics, Krasnoyarsk State Medical University named after Prof. 
      V.F. Voino-Yasenetsky, Krasnoyarsk 660022, Russia.
FAU - Noda, Mami
AU  - Noda M
AD  - Laboratory of Pathophysiology, Graduate School of Pharmaceutical Sciences, Kyushu 
      University, Fukuoka 8128582, Japan.
FAU - Salmina, Alla B
AU  - Salmina AB
AD  - Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State 
      Medical University named after Prof. V.F. Voino-Yasenetsky, P. Zheleznyaka str., 
      1, Krasnoyarsk 660022, Russia.
AD  - Interdisciplinary Center of Critical Technologies in Medicine, Department of 
      Physiology of Humans and Animals, Saratov State University named after N.G. 
      Chernyshevsky, Saratov 410012, Russia.
AD  - Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, 
      Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, 
      Krasnoyarsk 660022, Russia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Germany
TA  - Rev Neurosci
JT  - Reviews in the neurosciences
JID - 8711016
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Astrocytes/metabolism
MH  - Blood-Brain Barrier/*metabolism
MH  - Brain/*metabolism
MH  - Cytokines/*metabolism
MH  - Humans
MH  - Pericytes/*cytology
MH  - *Permeability
OTO - NOTNLM
OT  - ATP
OT  - astrocyte
OT  - blood-brain barrier
OT  - cytokines
OT  - endothelium
OT  - glutamate
OT  - microglia
OT  - pericyte
EDAT- 2018/01/08 06:00
MHDA- 2018/10/24 06:00
CRDT- 2018/01/08 06:00
PHST- 2017/11/02 00:00 [received]
PHST- 2017/11/26 00:00 [accepted]
PHST- 2018/01/08 06:00 [pubmed]
PHST- 2018/10/24 06:00 [medline]
PHST- 2018/01/08 06:00 [entrez]
AID - /j/revneuro.ahead-of-print/revneuro-2017-0092/revneuro-2017-0092.xml [pii]
AID - 10.1515/revneuro-2017-0092 [doi]
PST - ppublish
SO  - Rev Neurosci. 2018 Jul 26;29(5):567-591. doi: 10.1515/revneuro-2017-0092.