PMID- 29307273 OWN - NLM STAT- MEDLINE DCOM- 20190109 LR - 20190109 IS - 2046-9055 (Electronic) IS - 2046-9047 (Linking) VI - 38 IP - 4 DP - 2018 Nov TI - Kikuchi-Fujimoto disease triggered by Salmonella enteritidis in a child with concurrent auto-immune thyroiditis and papilloedema. PG - 298-301 LID - 10.1080/20469047.2017.1420523 [doi] AB - Kikuchi-Fujimoto disease (KFD) is a histiocytic necrotising lymphadenitis characterised by painful cervical lymphadenopathy, fever, malaise and weight loss. Infections, auto-immune pathogenesis and a genetic association have been implicated. A 12-year-old boy presented with a 1-month history of fever, abdominal pain, constipation and weight loss, and a painful lymph node was detected in the right axilla. Chest CT demonstrated multiple lymph nodes, especially in the left mediastinum. Salmonella enteritidis group D was detected in a blood culture and he was treated with ceftriaxone, followed by meropenem. An axillary lymph node biopsy demonstrated necrotising histiocytic lymphadenitis and KFD was diagnosed. He was discharged 35 days after admission. He was re-admitted 3 weeks later with recurrence of symptoms and headache and was found to have papilloedema of the left eye and auto-immune thyroiditis. Intravenous immunoglobulin (IVIG) 400 mg/kg/day was administered for 5 days. The fever and papilloedema slowly resolved and, subsequently, the thyroiditis, and he has remained well on follow-up. This is the first report of an association of S. enteritidis infection and papilloedema with KFD. IVIG may be required in prolonged or recurrent cases and in those with an auto-immune association. FAU - Altinel Acoglu, Esma AU - Altinel Acoglu E AD - a Departments of Pediatrics , Dr Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital , Ankara , Turkey. FAU - Sari, Eyup AU - Sari E AD - a Departments of Pediatrics , Dr Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital , Ankara , Turkey. FAU - Sahin, Gurses AU - Sahin G AD - b Departments of Pediatric Oncology , Dr Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital , Ankara , Turkey. FAU - Oguz, Melahat Melek AU - Oguz MM AUID- ORCID: 0000-0002-4196-4469 AD - a Departments of Pediatrics , Dr Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital , Ankara , Turkey. FAU - Akcaboy, Meltem AU - Akcaboy M AD - a Departments of Pediatrics , Dr Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital , Ankara , Turkey. FAU - Zorlu, Pelin AU - Zorlu P AD - a Departments of Pediatrics , Dr Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital , Ankara , Turkey. FAU - Senel, Saliha AU - Senel S AD - a Departments of Pediatrics , Dr Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital , Ankara , Turkey. LA - eng PT - Case Reports PT - Journal Article DEP - 20180108 PL - England TA - Paediatr Int Child Health JT - Paediatrics and international child health JID - 101582666 RN - 0 (Anti-Bacterial Agents) RN - 0 (Immunoglobulins, Intravenous) RN - 0 (Immunologic Factors) RN - 75J73V1629 (Ceftriaxone) RN - FV9J3JU8B1 (Meropenem) SB - IM MH - Anti-Bacterial Agents/administration & dosage MH - Biopsy MH - Blood/microbiology MH - Ceftriaxone/administration & dosage MH - Child MH - Histiocytic Necrotizing Lymphadenitis/*etiology/pathology MH - Humans MH - Immunoglobulins, Intravenous/administration & dosage MH - Immunologic Factors/administration & dosage MH - Lymph Nodes/pathology MH - Macular Edema/*etiology/pathology MH - Male MH - Mediastinum/pathology MH - Meropenem/administration & dosage MH - Radiography, Thoracic MH - Salmonella Infections/*complications/*diagnosis/microbiology/pathology MH - Salmonella enteritidis/*isolation & purification MH - Thyroiditis, Autoimmune/*etiology/pathology MH - Tomography, X-Ray Computed MH - Treatment Outcome OTO - NOTNLM OT - Kikuchi-Fujimoto disease OT - Salmonella enteritidis OT - histiocytic necrotising lymphadenitis OT - lymphadenopathy OT - salmonellosis EDAT- 2018/01/09 06:00 MHDA- 2019/01/10 06:00 CRDT- 2018/01/09 06:00 PHST- 2018/01/09 06:00 [pubmed] PHST- 2019/01/10 06:00 [medline] PHST- 2018/01/09 06:00 [entrez] AID - 10.1080/20469047.2017.1420523 [doi] PST - ppublish SO - Paediatr Int Child Health. 2018 Nov;38(4):298-301. doi: 10.1080/20469047.2017.1420523. Epub 2018 Jan 8.