PMID- 29307291
OWN - NLM
STAT- MEDLINE
DCOM- 20190704
LR  - 20240327
IS  - 1477-0970 (Electronic)
IS  - 1352-4585 (Print)
IS  - 1352-4585 (Linking)
VI  - 24
IP  - 1
DP  - 2018 Jan
TI  - Viruses in chronic progressive neurologic disease.
PG  - 48-52
LID - 10.1177/1352458517737392 [doi]
AB  - Viruses have long been implicated as triggers of disease onset and progression in 
      multiple sclerosis (MS) and similar neuroinflammatory disorders. Decades of 
      epidemiological, molecular, and pathologic studies have most strongly linked the 
      human herpesviruses Epstein-Barr virus (EBV) and human herpesvirus 6 (HHV-6) with 
      MS. However, these viruses are ubiquitous in the general population and typically 
      acquired decades before disease presentation, complicating the study of how they 
      might contribute to disease. As experimental animal models may help elucidate 
      mechanisms that have linked viruses with MS, we have been studying HHV-6 
      infections in a small nonhuman primate. We recently demonstrated that the 
      subsequent induction of an MS-like experimental neuroinflammatory disease results 
      in significantly accelerated disease in HHV-6 inoculated marmosets compared to 
      controls. Ultimately, disease intervention in the form of clinical trials with an 
      antiviral agent is the best way to concretely demonstrate a role for HHV-6 or any 
      other virus in MS.
FAU - Leibovitch, Emily C
AU  - Leibovitch EC
AD  - Viral Immunology Section, Neuroimmunology Branch, National Institute of 
      Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 
      USA.
FAU - Jacobson, Steven
AU  - Jacobson S
AD  - Viral Immunology Section, Neuroimmunology Branch, National Institute of 
      Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 
      USA.
LA  - eng
GR  - Z01 NS002817-18/Intramural NIH HHS/United States
GR  - Z01 NS002817-19/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - England
TA  - Mult Scler
JT  - Multiple sclerosis (Houndmills, Basingstoke, England)
JID - 9509185
SB  - IM
MH  - Animals
MH  - Herpesvirus 6, Human
MH  - Humans
MH  - Multiple Sclerosis/*virology
MH  - Nervous System Diseases/virology
MH  - Roseolovirus Infections/*complications
PMC - PMC5777331
MID - NIHMS909359
OTO - NOTNLM
OT  - Human herpesvirus 6 (HHV-6)
OT  - central nervous system inflammation
OT  - herpesviruses
OT  - multiple sclerosis
OT  - viral triggers
EDAT- 2018/01/09 06:00
MHDA- 2019/07/05 06:00
PMCR- 2019/01/01
CRDT- 2018/01/09 06:00
PHST- 2018/01/09 06:00 [entrez]
PHST- 2018/01/09 06:00 [pubmed]
PHST- 2019/07/05 06:00 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.1177/1352458517737392 [doi]
PST - ppublish
SO  - Mult Scler. 2018 Jan;24(1):48-52. doi: 10.1177/1352458517737392.