PMID- 29307576
OWN - NLM
STAT- MEDLINE
DCOM- 20180926
LR  - 20220331
IS  - 1878-0334 (Electronic)
IS  - 1871-4021 (Linking)
VI  - 12
IP  - 3
DP  - 2018 May
TI  - Oxidative stress biomarkers in type 2 diabetes mellitus for assessment of 
      cardiovascular disease risk.
PG  - 455-462
LID - S1871-4021(17)30465-4 [pii]
LID - 10.1016/j.dsx.2017.12.029 [doi]
AB  - AIMS: Type-2 Diabetes Mellitus (T2DM) is one of the most prevalent and 
      progressive metabolic conditions affecting approximately 8.5% of the global 
      population. Individuals with T2DM have a significantly increased risk of 
      developing chronic conditions such as cardiovascular disease (CVD) and its 
      associated complications, therefore, it is of great importance to establish 
      strategies for combatting T2DM and its associated chronic conditions. Current 
      literature has identified several biomarkers that are known to play a key role in 
      the pathogenesis of CVD. Many of these biomarkers affecting CVD are influenced by 
      an increase in oxidative stress as seen in T2DM. The purpose of this review is to 
      analyse and correlate the oxidative stress-related biomarkers that have been 
      identified in the literature to provide an updated summary of their significance 
      in CVD risk factors. DATA SYNTHESIS: This review has analysed current research on 
      T2DM, CVD, and oxidative stress. Four key cardiovascular risk factors: 
      thrombosis, inflammation, vascular homeostasis and cellular proliferation were 
      searched to identify potential biomarkers for this review. These biomarkers stem 
      from seven major cellular pathways; NF-kappaB, Keap1-Nrf2, protein kinase-C, 
      macrophage activation, arachidonic acid mobilisation, endothelial dysfunction and 
      advanced glycation end products. CONCLUSIONS: The pathways and biomarkers were 
      analysed to show their role as contributing factors to CVD development and a 
      summary is made regarding the assessment of cardiovascular risk in T2DM 
      individuals.
CI  - Copyright (c) 2017. Published by Elsevier Ltd.
FAU - Robson, Roy
AU  - Robson R
AD  - School of Medical Science, Menzies Health Institute Queensland, Gold Coast 
      Campus, Griffith University, QLD 4222, Australia.
FAU - Kundur, Avinash R
AU  - Kundur AR
AD  - School of Medical Science, Menzies Health Institute Queensland, Gold Coast 
      Campus, Griffith University, QLD 4222, Australia.
FAU - Singh, Indu
AU  - Singh I
AD  - School of Medical Science, Menzies Health Institute Queensland, Gold Coast 
      Campus, Griffith University, QLD 4222, Australia. Electronic address: 
      i.singh@griffith.edu.au.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20171230
PL  - Netherlands
TA  - Diabetes Metab Syndr
JT  - Diabetes & metabolic syndrome
JID - 101462250
RN  - 0 (Biomarkers)
SB  - IM
MH  - Biomarkers/*analysis
MH  - Cardiovascular Diseases/*diagnosis/*epidemiology
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Humans
MH  - Incidence
MH  - *Oxidative Stress
MH  - Prognosis
MH  - Risk Factors
OTO - NOTNLM
OT  - Cardiovascular disease
OT  - Oxidative stress
OT  - Thrombosis
OT  - Type-2 diabetes mellitus
EDAT- 2018/01/09 06:00
MHDA- 2018/09/27 06:00
CRDT- 2018/01/09 06:00
PHST- 2017/12/18 00:00 [received]
PHST- 2017/12/27 00:00 [accepted]
PHST- 2018/01/09 06:00 [pubmed]
PHST- 2018/09/27 06:00 [medline]
PHST- 2018/01/09 06:00 [entrez]
AID - S1871-4021(17)30465-4 [pii]
AID - 10.1016/j.dsx.2017.12.029 [doi]
PST - ppublish
SO  - Diabetes Metab Syndr. 2018 May;12(3):455-462. doi: 10.1016/j.dsx.2017.12.029. 
      Epub 2017 Dec 30.