PMID- 29308676
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20211204
IS  - 1744-4160 (Electronic)
IS  - 1381-3455 (Linking)
VI  - 124
IP  - 5
DP  - 2018 Dec
TI  - Vitamin D protection from rat diabetic nephropathy is partly mediated through 
      Klotho expression and renin-angiotensin inhibition.
PG  - 461-467
LID - 10.1080/13813455.2018.1423624 [doi]
AB  - OBJECTIVE: We hypothesised that vitamin D has a beneficial renal protective 
      effect from diabetic nephropathy (DN). METHODS: Four rat groups were included: 
      normal control (control), type 2 diabetes for eight weeks (DM), treated group 
      with angiotensin receptor blocker losartan (DM + L), and vitamin D-treated group 
      started from the onset of diabetes (DM + Vit D). RESULTS: In the both treated 
      groups, we found a significant (p < .05) reduction in the renal pro-inflammatory 
      and profibrotic markers induced by diabetes. Vitamin D caused more reduction in 
      monocyte chemoattractant protein-1 (MCP-1), transforming growth factor (TGFbeta-1), 
      and renin-angiotensin levels that gave better kidney function compared to the 
      DM + L group. CONCLUSION: Vitamin D may have a valuable role in the renal 
      protective effect from DN, this may occur via expression of its VDR, Klotho and 
      blocking renin-angiotensin activation, so vitamin D should be considered as a 
      target in renal prophylactic measures against DN.
FAU - Eltablawy, Nashwa
AU  - Eltablawy N
AD  - a Department of Medical Physiology , Kasr Alainy, Faculty of Medicine, Cairo 
      University , Cairo , Egypt.
FAU - Ashour, Hend
AU  - Ashour H
AUID- ORCID: 0000-0002-5423-7228
AD  - a Department of Medical Physiology , Kasr Alainy, Faculty of Medicine, Cairo 
      University , Cairo , Egypt.
FAU - Rashed, Laila Ahmed
AU  - Rashed LA
AD  - b Department of Medical Biochemistry , Kasr Alainy, Faculty of Medicine, Cairo 
      University , Cairo , Egypt.
FAU - Hamza, Wael Mostafa
AU  - Hamza WM
AD  - c Department of Pathology (Nephropathology) , Kasr Alainy, Faculty of Medicine, 
      Cairo University , Cairo , Egypt.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20180108
PL  - England
TA  - Arch Physiol Biochem
JT  - Archives of physiology and biochemistry
JID - 9510153
RN  - 0 (Angiotensin II Type 1 Receptor Blockers)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Biomarkers)
RN  - 0 (Receptors, Calcitriol)
RN  - 1406-16-2 (Vitamin D)
RN  - EC 3.2.1.31 (Glucuronidase)
RN  - EC 3.2.1.31 (Klotho Proteins)
RN  - JMS50MPO89 (Losartan)
SB  - IM
MH  - Angiotensin II Type 1 Receptor Blockers/therapeutic use
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/therapeutic use
MH  - Biomarkers/blood/metabolism
MH  - Diabetes Mellitus, Type 2/complications/drug therapy/therapy
MH  - Diabetic Nephropathies/immunology/metabolism/physiopathology/*prevention & 
      control
MH  - *Dietary Supplements
MH  - Down-Regulation
MH  - *Gene Expression Regulation
MH  - Glucuronidase/chemistry/genetics/*metabolism
MH  - Kidney/drug effects/immunology/*metabolism/physiopathology
MH  - Klotho Proteins
MH  - Losartan/therapeutic use
MH  - Male
MH  - Random Allocation
MH  - Rats, Wistar
MH  - Receptors, Calcitriol/agonists/genetics/metabolism
MH  - Renal Insufficiency/complications/immunology/metabolism/*prevention & control
MH  - Renin-Angiotensin System/drug effects
MH  - Reproducibility of Results
MH  - Vitamin D/*therapeutic use
OTO - NOTNLM
OT  - Klotho
OT  - Vitamin D
OT  - diabetic nephropathy
OT  - losartan
EDAT- 2018/01/09 06:00
MHDA- 2018/12/12 06:00
CRDT- 2018/01/09 06:00
PHST- 2018/01/09 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/01/09 06:00 [entrez]
AID - 10.1080/13813455.2018.1423624 [doi]
PST - ppublish
SO  - Arch Physiol Biochem. 2018 Dec;124(5):461-467. doi: 
      10.1080/13813455.2018.1423624. Epub 2018 Jan 8.