PMID- 29309801
OWN - NLM
STAT- MEDLINE
DCOM- 20190118
LR  - 20211204
IS  - 1873-5169 (Electronic)
IS  - 0196-9781 (Linking)
VI  - 102
DP  - 2018 Apr
TI  - Moderate treadmill exercise ameliorates amyloid-beta-induced learning and memory 
      impairment, possibly via increasing AMPK activity and up-regulation of the 
      PGC-1alpha/FNDC5/BDNF pathway.
PG  - 78-88
LID - S0196-9781(17)30406-0 [pii]
LID - 10.1016/j.peptides.2017.12.027 [doi]
AB  - Alzheimer's disease (AD) is a neurodegenerative disorder associated with loss of 
      memory and cognitive abilities. Previous evidence suggested that exercise 
      ameliorates learning and memory deficits by increasing brain derived neurotrophic 
      factor (BDNF) and activating downstream pathways in AD animal models. However, 
      upstream pathways related to increase BDNF induced by exercise in AD animal 
      models are not well known. We investigated the effects of moderate treadmill 
      exercise on Abeta-induced learning and memory impairment as well as the upstream 
      pathway responsible for increasing hippocampal BDNF in an animal model of AD. 
      Animals were divided into five groups: Intact, Sham, Abeta(1-42), Sham-exercise 
      (Sham-exe) and Abeta(1-42)-exercise (Abeta-exe). Abeta was microinjected into the CA1 area 
      of the hippocampus and then animals in the exercise groups were subjected to 
      moderate treadmill exercise (for 4 weeks with 5 sessions per week) 7 days after 
      microinjection. In the present study the Morris water maze (MWM) test was used to 
      assess spatial learning and memory. Hippocampal mRNA levels of BDNF, peroxisome 
      proliferator-activated receptor gamma co-activator 1 alpha (PGC-1alpha), fibronectin 
      type III domain-containing 5 (FNDC5) as well as protein levels of AMPK-activated 
      protein kinase (AMPK), PGC-1alpha, BDNF, phosphorylation of AMPK were measured. Our 
      results showed that intra-hippocampal injection of Abeta(1-42) impaired spatial 
      learning and memory which was accompanied by reduced AMPK activity 
      (p-AMPK/total-AMPK ratio) and suppression of the PGC-1alpha/FNDC5/BDNF pathway in the 
      hippocampus of rats. In contrast, moderate treadmill exercise ameliorated the 
      Abeta(1-42)-induced spatial learning and memory deficit, which was accompanied by 
      restored AMPK activity and PGC-1alpha/FNDC5/BDNF levels. Our results suggest that the 
      increased AMPK activity and up-regulation of the PGC-1alpha/FNDC5/BDNF pathway by 
      exercise are likely involved in mediating the beneficial effects of exercise on 
      Abeta-induced learning and memory impairment.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Azimi, Mohammad
AU  - Azimi M
AD  - Department of Physical Education and Sport Sciences, Faculty of Humanities, 
      Tarbiat Modares University, Tehran, Iran.
FAU - Gharakhanlou, Reza
AU  - Gharakhanlou R
AD  - Department of Physical Education and Sport Sciences, Faculty of Humanities, 
      Tarbiat Modares University, Tehran, Iran. Electronic address: 
      ghara_re@modares.ac.ir.
FAU - Naghdi, Nasser
AU  - Naghdi N
AD  - Department of Physiology and Pharmacology, Pasteur Institute of Iran, 13164, 
      Tehran, Iran.
FAU - Khodadadi, Davar
AU  - Khodadadi D
AD  - Department of Physical Education and Sport Sciences, Faculty of Humanities, 
      Tarbiat Modares University, Tehran, Iran.
FAU - Heysieattalab, Soomaayeh
AU  - Heysieattalab S
AD  - Cognitive Neuroscience Division, Faculty of Education and Psychology, University 
      of Tabriz, Tabriz, Iran.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180105
PL  - United States
TA  - Peptides
JT  - Peptides
JID - 8008690
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Bdnf protein, rat)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (FNDC5 protein, rat)
RN  - 0 (Fibronectins)
RN  - 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
RN  - 0 (Ppargc1a protein, rat)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.11.3 (AMP-Activated Protein Kinase Kinases)
SB  - IM
CIN - Peptides. 2018 Apr;102:75-77. PMID: 29524561
MH  - AMP-Activated Protein Kinase Kinases
MH  - Alzheimer Disease/genetics/physiopathology/*therapy
MH  - Amyloid beta-Peptides/toxicity
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - Disease Models, Animal
MH  - Exercise Test
MH  - Fibronectins/genetics
MH  - Hippocampus/metabolism
MH  - Humans
MH  - Learning Disabilities/chemically induced/genetics/physiopathology/*therapy
MH  - Memory Disorders/chemically induced/genetics/physiopathology/*therapy
MH  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/genetics
MH  - *Physical Conditioning, Animal
MH  - Protein Kinases/genetics
MH  - Rats
MH  - Signal Transduction
OTO - NOTNLM
OT  - AMPK
OT  - Alzheimer's disease
OT  - BDNF
OT  - FNDC5
OT  - Moderate treadmill exercise
OT  - PGC-1alpha
EDAT- 2018/01/09 06:00
MHDA- 2019/01/19 06:00
CRDT- 2018/01/09 06:00
PHST- 2017/09/19 00:00 [received]
PHST- 2017/12/27 00:00 [revised]
PHST- 2017/12/29 00:00 [accepted]
PHST- 2018/01/09 06:00 [pubmed]
PHST- 2019/01/19 06:00 [medline]
PHST- 2018/01/09 06:00 [entrez]
AID - S0196-9781(17)30406-0 [pii]
AID - 10.1016/j.peptides.2017.12.027 [doi]
PST - ppublish
SO  - Peptides. 2018 Apr;102:78-88. doi: 10.1016/j.peptides.2017.12.027. Epub 2018 Jan 
      5.