PMID- 29310279
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20180316
LR  - 20180316
IS  - 1873-3573 (Electronic)
IS  - 0039-9140 (Linking)
VI  - 179
DP  - 2018 Mar 1
TI  - Enhancing reproducibility of SALDI MS detection by concentrating analytes within 
      laser spot.
PG  - 583-587
LID - S0039-9140(17)31184-0 [pii]
LID - 10.1016/j.talanta.2017.11.056 [doi]
AB  - Surface-assisted laser desorption/ionization time-of-flight mass spectrometry 
      (SALDI TOF MS) has become one of the most important analytical methods due to its 
      less interference at low molecular weight range. However, it is still a challenge 
      to obtain a good reproducibility of SALDI TOF MS because of the inhomogeneous 
      distribution of analyte molecules induced by coffee ring effect. We propose a 
      universal and reliable method to eliminate the coffee ring effect by 
      concentrating all the analyte molecules within the laser spot. This method 
      exhibits an excellent reproducibility of spot-to-spot and substrate-to-substrate, 
      and the relative standard deviations (RSDs) for different concentrations are 
      lower than 12.6%. It also performs good linear dependency (R(2) > 0.98) in the 
      log-log plot with the concentration range of 1nM to 1muM, and the limit of 
      detection for R6G is down to 1fmol.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Teng, Fei
AU  - Teng F
AD  - State Key Laboratory of Supramolecular Structure and Materials, College of 
      Chemistry, Jilin University, Changchun 130012, PR China.
FAU - Zhu, Qunyan
AU  - Zhu Q
AD  - State Key Laboratory of Supramolecular Structure and Materials, College of 
      Chemistry, Jilin University, Changchun 130012, PR China.
FAU - Wang, Yalei
AU  - Wang Y
AD  - State Key Laboratory of Supramolecular Structure and Materials, College of 
      Chemistry, Jilin University, Changchun 130012, PR China.
FAU - Du, Juan
AU  - Du J
AD  - State Key Laboratory of Supramolecular Structure and Materials, College of 
      Chemistry, Jilin University, Changchun 130012, PR China.
FAU - Lu, Nan
AU  - Lu N
AD  - State Key Laboratory of Supramolecular Structure and Materials, College of 
      Chemistry, Jilin University, Changchun 130012, PR China. Electronic address: 
      luenan@jlu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20171128
PL  - Netherlands
TA  - Talanta
JT  - Talanta
JID - 2984816R
OTO - NOTNLM
OT  - Coffee ring effect
OT  - Concentrating analyte molecules
OT  - Hydrophobic
OT  - Improving reproducibility
OT  - SALDI TOF MS
EDAT- 2018/01/10 06:00
MHDA- 2018/01/10 06:01
CRDT- 2018/01/10 06:00
PHST- 2017/06/13 00:00 [received]
PHST- 2017/11/08 00:00 [revised]
PHST- 2017/11/26 00:00 [accepted]
PHST- 2018/01/10 06:00 [entrez]
PHST- 2018/01/10 06:00 [pubmed]
PHST- 2018/01/10 06:01 [medline]
AID - S0039-9140(17)31184-0 [pii]
AID - 10.1016/j.talanta.2017.11.056 [doi]
PST - ppublish
SO  - Talanta. 2018 Mar 1;179:583-587. doi: 10.1016/j.talanta.2017.11.056. Epub 2017 
      Nov 28.