PMID- 29310728
OWN - NLM
STAT- MEDLINE
DCOM- 20181005
LR  - 20221207
IS  - 1601-5215 (Electronic)
IS  - 0924-2708 (Linking)
VI  - 30
IP  - 3
DP  - 2018 Jun
TI  - BDNF and NRG1 polymorphisms and temperament in selective serotonin reuptake 
      inhibitor-treated patients with major depression.
PG  - 168-174
LID - 10.1017/neu.2017.37 [doi]
AB  - OBJECTIVE: We investigated the separate effects of and possible interactions 
      between the functional polymorphisms of brain-derived neurotrophic factor (BDNF) 
      rs11030101, BDNF rs61888800, and neuregulin-1 (NRG1) rs3924999 and NRG1 rs6994992 
      on change of temperament scores in a clinical sample of subjects with major 
      depression (MDD), who received selective serotonin reuptake inhibitor treatment 
      for a period of 6 weeks. METHODS: The study population consisted of 98 Finnish 
      individuals with MDD. They were assessed by the 107-item Temperament and 
      Character Inventory temperament questionnaire (version IX) and the 
      Montgomery-Asberg Depression Rating Scale (MADRS). In general linear univariate 
      models (GLM) for novelty seeking (NS) or reward dependence (RD) change age, 
      gender, MADRS score change and BDNF and NRG1 genotypes were used as explaining 
      explanatory variables. RESULTS: Mean comparisons between corresponding 
      temperament dimensions and genotypes showed significant differences between NS 
      change and BDNF rs61888800 T-carrying status (mean difference: GG 0.30, GT/TT 
      2.47, p=0.022, t-test) and between RD change and NRG1 rs3924999 A-carrying status 
      (mean difference: GG 1.21, GA/AA -0.33, p=0.003). In GLM models for NS change the 
      significant predictors comprised BDNF rs61888800 T-carrying status, age and MADRS 
      score change (model 1), and additionally NRG1 rs6994992 T-carrying status (model 
      2). For RD change the predictors included NRG1 rs3924999 A-carrying status, age 
      and MADRS score change (model 1) and additionally gender (model 2). CONCLUSION: 
      According to the current results both BDNF and NRG1 are associated with 
      temperament traits during depression. These results warrant further studies 
      regarding the impact of this association on depression recovery.
FAU - Andre, Kadri
AU  - Andre K
AD  - 1Faculty of Medicine and Life Sciences,University of Tampere,Tampere,Finland.
FAU - Kampman, Olli
AU  - Kampman O
AD  - 1Faculty of Medicine and Life Sciences,University of Tampere,Tampere,Finland.
FAU - Viikki, Merja
AU  - Viikki M
AD  - 1Faculty of Medicine and Life Sciences,University of Tampere,Tampere,Finland.
FAU - Setala-Soikkeli, Eija
AU  - Setala-Soikkeli E
AD  - 4Department of Psychiatry,Kanta-Hame Hospital District,Hameenlinna,Finland.
FAU - Illi, Ari
AU  - Illi A
AD  - 1Faculty of Medicine and Life Sciences,University of Tampere,Tampere,Finland.
FAU - Mononen, Nina
AU  - Mononen N
AD  - 1Faculty of Medicine and Life Sciences,University of Tampere,Tampere,Finland.
FAU - Lehtimaki, Terho
AU  - Lehtimaki T
AD  - 1Faculty of Medicine and Life Sciences,University of Tampere,Tampere,Finland.
FAU - Leinonen, Esa
AU  - Leinonen E
AD  - 1Faculty of Medicine and Life Sciences,University of Tampere,Tampere,Finland.
LA  - eng
PT  - Journal Article
DEP - 20180109
PL  - England
TA  - Acta Neuropsychiatr
JT  - Acta neuropsychiatrica
JID - 9612501
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (NRG1 protein, human)
RN  - 0 (Neuregulin-1)
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - *Depressive Disorder, Major/drug therapy/genetics/physiopathology
MH  - *Exploratory Behavior/drug effects/physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuregulin-1/*genetics
MH  - Personality Assessment
MH  - Psychiatric Status Rating Scales
MH  - *Reward
MH  - Selective Serotonin Reuptake Inhibitors/administration & dosage/*pharmacology
MH  - *Temperament/drug effects/physiology
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - depression
OT  - neuregulin-1
OT  - temperament
EDAT- 2018/01/10 06:00
MHDA- 2018/10/06 06:00
CRDT- 2018/01/10 06:00
PHST- 2018/01/10 06:00 [pubmed]
PHST- 2018/10/06 06:00 [medline]
PHST- 2018/01/10 06:00 [entrez]
AID - S0924270817000370 [pii]
AID - 10.1017/neu.2017.37 [doi]
PST - ppublish
SO  - Acta Neuropsychiatr. 2018 Jun;30(3):168-174. doi: 10.1017/neu.2017.37. Epub 2018 
      Jan 9.