PMID- 29310838 OWN - NLM STAT- MEDLINE DCOM- 20190117 LR - 20190117 IS - 2210-7762 (Print) VI - 220 DP - 2018 Jan TI - A leukemic double-hit follicular lymphoma associated with a complex variant translocation, t(8;14;18)(q24;q32;q21), involving BCL2, MYC, and IGH. PG - 44-48 LID - S2210-7762(17)30310-1 [pii] LID - 10.1016/j.cancergen.2017.11.007 [doi] AB - Double-hit lymphoma (DHL) is defined as lymphoma with concurrent BCL2 and MYC translocations. While the most common histological subtype of DHL is diffuse large B-cell lymphoma, the present patient had leukemic follicular lymphoma (FL). A 52-year-old man was admitted to our hospital due to general fatigue and cervical and inguinal lymph node swelling. The patient was leukemic and the pathological diagnosis of the inguinal lymph node was FL grade 1. Chromosomal analysis revealed a complex karyotype including a rare three-way translocation t(8;14;18)(q24;q32;q21) involving the BCL2, MYC, and IGH genes. Based on a combination of fluorescence in situ hybridization (FISH), using BCL2, MYC and IGH, and spectral karyotyping (SKY), the karyotype was interpreted as being the result of a multistep mechanism in which the precursor B-cell gained t(14;18) in the bone marrow and acquired a translocation between der(14)t(14;18) and chromosome 8 in the germinal center, resulting in t(8;14;18). The pathological diagnosis was consistently FL, not only at presentation but even after a second relapse. The patient responded well to standard chemotherapies but relapsed after a short remission. This patient is a unique case of leukemic DH-FL with t(8;14;18) that remained in FL even at a second relapse. CI - Copyright (c) 2017 Elsevier Inc. All rights reserved. FAU - Minakata, Daisuke AU - Minakata D AD - Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan. FAU - Sato, Kazuya AU - Sato K AD - Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan. FAU - Ikeda, Takashi AU - Ikeda T AD - Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan. FAU - Toda, Yumiko AU - Toda Y AD - Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan. FAU - Ito, Shoko AU - Ito S AD - Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan. FAU - Mashima, Kiyomi AU - Mashima K AD - Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan. FAU - Umino, Kento AU - Umino K AD - Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan. FAU - Nakano, Hirofumi AU - Nakano H AD - Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan. FAU - Yamasaki, Ryoko AU - Yamasaki R AD - Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan. FAU - Morita, Kaoru AU - Morita K AD - Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan. FAU - Kawasaki, Yasufumi AU - Kawasaki Y AD - Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan. FAU - Sugimoto, Miyuki AU - Sugimoto M AD - Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan. FAU - Yamamoto, Chihiro AU - Yamamoto C AD - Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan. FAU - Ashizawa, Masahiro AU - Ashizawa M AD - Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan. FAU - Hatano, Kaoru AU - Hatano K AD - Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan. FAU - Oh, Iekuni AU - Oh I AD - Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan. FAU - Fujiwara, Shin-Ichiro AU - Fujiwara SI AD - Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan. FAU - Ohmine, Ken AU - Ohmine K AD - Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan. FAU - Kawata, Hirotoshi AU - Kawata H AD - Department of Pathology, Jichi Medical University, Tochigi, Japan. FAU - Muroi, Kazuo AU - Muroi K AD - Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan. FAU - Miura, Ikuo AU - Miura I AD - Division of Hematology and Oncology, Department of Medicine, St. Marianna University School of Medicine, Kanagawa, Japan. FAU - Kanda, Yoshinobu AU - Kanda Y AD - Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan. Electronic address: ycanda-tky@umin.ac.jp. LA - eng PT - Case Reports PT - Journal Article DEP - 20171128 PL - United States TA - Cancer Genet JT - Cancer genetics JID - 101539150 RN - 0 (BCL2 protein, human) RN - 0 (Immunoglobulin Heavy Chains) RN - 0 (MYC protein, human) RN - 0 (Proto-Oncogene Proteins c-bcl-2) RN - 0 (Proto-Oncogene Proteins c-myc) SB - IM MH - Chromosomes, Human, Pair 14 MH - Chromosomes, Human, Pair 18 MH - Chromosomes, Human, Pair 8 MH - Cytogenetic Analysis/methods MH - Flow Cytometry MH - Genes, myc MH - Humans MH - Immunoglobulin Heavy Chains/*genetics MH - Lymphoma, Follicular/*genetics/metabolism MH - Male MH - Middle Aged MH - Proto-Oncogene Proteins c-bcl-2/*genetics MH - Proto-Oncogene Proteins c-myc/*genetics MH - *Translocation, Genetic OTO - NOTNLM OT - Double-hit lymphoma OT - t(8;14;18) OT - three-way translocation EDAT- 2018/01/10 06:00 MHDA- 2019/01/18 06:00 CRDT- 2018/01/10 06:00 PHST- 2017/07/25 00:00 [received] PHST- 2017/11/13 00:00 [revised] PHST- 2017/11/21 00:00 [accepted] PHST- 2018/01/10 06:00 [entrez] PHST- 2018/01/10 06:00 [pubmed] PHST- 2019/01/18 06:00 [medline] AID - S2210-7762(17)30310-1 [pii] AID - 10.1016/j.cancergen.2017.11.007 [doi] PST - ppublish SO - Cancer Genet. 2018 Jan;220:44-48. doi: 10.1016/j.cancergen.2017.11.007. Epub 2017 Nov 28.