PMID- 29310968
OWN - NLM
STAT- MEDLINE
DCOM- 20180926
LR  - 20180926
IS  - 1878-0334 (Electronic)
IS  - 1871-4021 (Linking)
VI  - 12
IP  - 3
DP  - 2018 May
TI  - Intercellular adhesion molecule-1 in diabetic patients with and without 
      microalbuminuria.
PG  - 365-368
LID - S1871-4021(17)30454-X [pii]
LID - 10.1016/j.dsx.2017.12.028 [doi]
AB  - BACKGROUND: Nephropathy is a major complication of type 2 diabetes mellitus 
      (T2DM) and is heralded by the insidious development of microalbuminuria (MA). It 
      is suggested that the serum levels of Intercellular Adhesion Molecule-1 (ICAM-1) 
      is correlated with diabetic nephropathy. In this cross-sectional study, we 
      evaluated serum ICAM-1 level in diabetic patients with and without MA. METHODS: A 
      total of 187 participants were enrolled and were classified into three groups 
      including 40 healthy controls and 2 diabetic groups with (n = 59) or without MA 
      (n = 88). Serum levels of ICAM-1, fasting plasma glucose (FPG), hemoglobin A1c 
      (HbA1c), total cholesterol, high density lipoprotein cholesterol, low density 
      lipoprotein cholesterol, very low density lipoprotein cholesterol and C-reactive 
      protein (CRP) were measured in all three groups. Statistical analyses were 
      performed using the SPSS software. A P-value less than 0.05 was considered 
      statistically significant. RESULTS: Serum levels of ICAM-1 were significantly 
      higher in diabetic patients irrespective of MA. Moreover, ICAM-1 levels in 
      patients with MA were significantly higher than patients without MA. Patients 
      with MA had significantly higher age and blood pressure compared to those without 
      MA (P = 0.001). Serum levels of ICAM-1 were significantly correlated with age and 
      HbA1c. CONCLUSIONS: Overall, serum ICAM-1 levels were significantly higher in 
      T2DM patients with MA and it may be associated with the severity of diabetic 
      kidney disease.
CI  - Copyright (c) 2017 Diabetes India. Published by Elsevier Ltd. All rights reserved.
FAU - Karimi, Zahra
AU  - Karimi Z
AD  - Division of Cardiovascular Medicine, Department of Medicine, Beth Israel 
      Deaconess Medical Center, Harvard Medical School, Boston, MA, United States; 
      Endocrinology and Metabolism Research Center, Vali-Asr Hospital, School of 
      Medicine, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Kahe, Farima
AU  - Kahe F
AD  - Division of Cardiovascular Medicine, Department of Medicine, Beth Israel 
      Deaconess Medical Center, Harvard Medical School, Boston, MA, United States; 
      Endocrinology and Metabolism Research Center, Vali-Asr Hospital, School of 
      Medicine, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Jamil, Adeel
AU  - Jamil A
AD  - James J. Peters Veterans Affairs Medical Center, Icahn School of Medicine at 
      Mount Sinai, Bronx, New York, United States.
FAU - Marszalek, Jolanta
AU  - Marszalek J
AD  - Department of Neurology, University of Arkansas for Medical Sciences, Little 
      Rock, AR, United States.
FAU - Ghanbari, Asiye
AU  - Ghanbari A
AD  - Endocrinology and Metabolism Research Center, Vali-Asr Hospital, School of 
      Medicine, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Afarideh, Mohsen
AU  - Afarideh M
AD  - Endocrinology and Metabolism Research Center, Vali-Asr Hospital, School of 
      Medicine, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Khajeh, Elias
AU  - Khajeh E
AD  - Endocrinology and Metabolism Research Center, Vali-Asr Hospital, School of 
      Medicine, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Noshad, Sina
AU  - Noshad S
AD  - Endocrinology and Metabolism Research Center, Vali-Asr Hospital, School of 
      Medicine, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Esteghamati, Alireza
AU  - Esteghamati A
AD  - Endocrinology and Metabolism Research Center, Vali-Asr Hospital, School of 
      Medicine, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Chi, Gerald
AU  - Chi G
AD  - Division of Cardiovascular Medicine, Department of Medicine, Beth Israel 
      Deaconess Medical Center, Harvard Medical School, Boston, MA, United States. 
      Electronic address: gerald.chi@baiminstitute.org.
LA  - eng
PT  - Journal Article
DEP - 20171228
PL  - Netherlands
TA  - Diabetes Metab Syndr
JT  - Diabetes & metabolic syndrome
JID - 101462250
RN  - 0 (Biomarkers)
RN  - 0 (ICAM1 protein, human)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Albuminuria/blood/*complications
MH  - Biomarkers/*blood
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/*physiopathology
MH  - Diabetic Nephropathies/*blood/diagnosis/etiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/*blood
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Risk Factors
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - ICAM-1
OT  - Microalbuminuria
EDAT- 2018/01/10 06:00
MHDA- 2018/09/27 06:00
CRDT- 2018/01/10 06:00
PHST- 2017/12/09 00:00 [received]
PHST- 2017/12/27 00:00 [accepted]
PHST- 2018/01/10 06:00 [pubmed]
PHST- 2018/09/27 06:00 [medline]
PHST- 2018/01/10 06:00 [entrez]
AID - S1871-4021(17)30454-X [pii]
AID - 10.1016/j.dsx.2017.12.028 [doi]
PST - ppublish
SO  - Diabetes Metab Syndr. 2018 May;12(3):365-368. doi: 10.1016/j.dsx.2017.12.028. 
      Epub 2017 Dec 28.