PMID- 29311068
OWN - NLM
STAT- MEDLINE
DCOM- 20190419
LR  - 20190419
IS  - 1098-6596 (Electronic)
IS  - 0066-4804 (Print)
IS  - 0066-4804 (Linking)
VI  - 62
IP  - 3
DP  - 2018 Mar
TI  - Identification of a Novel Genomic Island Associated with vanD-Type Vancomycin 
      Resistance in Six Dutch Vancomycin-Resistant Enterococcus faecium Isolates.
LID - 10.1128/AAC.01793-17 [doi]
LID - e01793-17
AB  - Genomic comparison of the first six Dutch vanD-type vancomycin-resistant 
      Enterococcus faecium (VRE) isolates with four vanD gene clusters from other 
      enterococcal species and anaerobic gut commensals revealed that the vanD gene 
      cluster was located on a genomic island of variable size. Phylogenetic inferences 
      revealed that the Dutch VRE isolates were genetically not closely related and 
      that genetic variation of the vanD-containing genomic island was not species 
      specific, suggesting that this island is transferred horizontally between 
      enterococci and anaerobic gut commensals.
CI  - Copyright (c) 2018 American Society for Microbiology.
FAU - Top, Janetta
AU  - Top J
AD  - Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, 
      The Netherlands j.top@umcutrecht.nl.
FAU - Sinnige, Jan C
AU  - Sinnige JC
AD  - Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, 
      The Netherlands.
FAU - Brouwer, Ellen C
AU  - Brouwer EC
AD  - Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, 
      The Netherlands.
FAU - Werner, Guido
AU  - Werner G
AD  - Division of Nosocomial Pathogens and Antibiotic Resistance, Department of 
      Infectious Diseases, Robert Koch Institute, Wernigerode Branch, Wernigerode, 
      Germany.
FAU - Corander, Jukka
AU  - Corander J
AD  - Faculty of Medicine, Department of Biostatistics, University of Oslo, Oslo, 
      Norway.
AD  - Department of Mathematics and Statistics, University of Helsinki, Helsinki, 
      Finland.
AD  - Infection Genomics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, 
      United Kingdom.
FAU - Severin, Juliette A
AU  - Severin JA
AD  - Department of Medical Microbiology and Infectious Diseases, Erasmus University 
      Medical Center, Rotterdam, The Netherlands.
FAU - Jansen, Rogier
AU  - Jansen R
AD  - Department of Medical Microbiology OLVG, Amsterdam, The Netherlands.
FAU - Bathoorn, E
AU  - Bathoorn E
AD  - Department of Medical Microbiology, University Medical Center Groningen, 
      Groningen, The Netherlands.
FAU - Bonten, Marc J M
AU  - Bonten MJM
AD  - Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, 
      The Netherlands.
FAU - Rossen, John W A
AU  - Rossen JWA
AD  - Department of Medical Microbiology, University Medical Center Groningen, 
      Groningen, The Netherlands.
FAU - Willems, Rob J L
AU  - Willems RJL
AD  - Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, 
      The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180223
PL  - United States
TA  - Antimicrob Agents Chemother
JT  - Antimicrobial agents and chemotherapy
JID - 0315061
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Bacterial Proteins)
RN  - 6Q205EH1VU (Vancomycin)
SB  - IM
MH  - Anti-Bacterial Agents/pharmacology
MH  - Bacterial Proteins/genetics/metabolism
MH  - Enterococcus faecium/*drug effects/genetics
MH  - Genomic Islands/*genetics
MH  - Microbial Sensitivity Tests
MH  - Multigene Family/genetics
MH  - Phylogeny
MH  - Vancomycin/pharmacology
MH  - Vancomycin Resistance/*genetics
PMC - PMC5826138
OTO - NOTNLM
OT  - Enterococcus faecium
OT  - genomic island
OT  - vanD type
OT  - vancomycin resistance
EDAT- 2018/01/10 06:00
MHDA- 2019/04/20 06:00
PMCR- 2018/08/23
CRDT- 2018/01/10 06:00
PHST- 2017/09/05 00:00 [received]
PHST- 2017/12/19 00:00 [accepted]
PHST- 2018/01/10 06:00 [pubmed]
PHST- 2019/04/20 06:00 [medline]
PHST- 2018/01/10 06:00 [entrez]
PHST- 2018/08/23 00:00 [pmc-release]
AID - AAC.01793-17 [pii]
AID - 01793-17 [pii]
AID - 10.1128/AAC.01793-17 [doi]
PST - epublish
SO  - Antimicrob Agents Chemother. 2018 Feb 23;62(3):e01793-17. doi: 
      10.1128/AAC.01793-17. Print 2018 Mar.