PMID- 29311260
OWN - NLM
STAT- MEDLINE
DCOM- 20180329
LR  - 20211204
IS  - 1477-9129 (Electronic)
IS  - 0950-1991 (Print)
IS  - 0950-1991 (Linking)
VI  - 145
IP  - 1
DP  - 2018 Jan 8
TI  - mTOR signaling in stem and progenitor cells.
LID - 10.1242/dev.152595 [doi]
LID - dev152595
AB  - The mammalian target of rapamycin (mTOR) senses nutrients and growth factors to 
      coordinate cell growth, metabolism and autophagy. Extensive research has mapped 
      the signaling pathways regulated by mTOR that are involved in human diseases, 
      such as cancer, and in diabetes and ageing. Recently, however, new studies have 
      demonstrated important roles for mTOR in promoting the differentiation of adult 
      stem cells, driving the growth and proliferation of stem and progenitor cells, 
      and dictating the differentiation program of multipotent stem cell populations. 
      Here, we review these advances, providing an overview of mTOR signaling and its 
      role in murine and human stem and progenitor cells.
CI  - (c) 2018. Published by The Company of Biologists Ltd.
FAU - Meng, Delong
AU  - Meng D
AD  - Department of Molecular Biology, University of Texas Southwestern Medical Center, 
      Dallas, TX 75390, USA.
AD  - Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern 
      Medical Center, Dallas, TX 75390, USA.
AD  - Hamon Center for Regenerative Science and Medicine, University of Texas 
      Southwestern Medical Center, Dallas, TX 75390, USA.
FAU - Frank, Anderson R
AU  - Frank AR
AD  - Department of Molecular Biology, University of Texas Southwestern Medical Center, 
      Dallas, TX 75390, USA.
AD  - Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern 
      Medical Center, Dallas, TX 75390, USA.
AD  - Hamon Center for Regenerative Science and Medicine, University of Texas 
      Southwestern Medical Center, Dallas, TX 75390, USA.
FAU - Jewell, Jenna L
AU  - Jewell JL
AUID- ORCID: 0000-0002-8021-9453
AD  - Department of Molecular Biology, University of Texas Southwestern Medical Center, 
      Dallas, TX 75390, USA jenna.jewell@utsouthwestern.edu.
AD  - Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern 
      Medical Center, Dallas, TX 75390, USA.
AD  - Hamon Center for Regenerative Science and Medicine, University of Texas 
      Southwestern Medical Center, Dallas, TX 75390, USA.
LA  - eng
GR  - T32 GM007062/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180108
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
RN  - 0 (Neoplasm Proteins)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Adult Stem Cells/*metabolism/pathology
MH  - Aging/metabolism/pathology
MH  - Animals
MH  - Diabetes Mellitus/metabolism/pathology
MH  - Humans
MH  - Multipotent Stem Cells/*metabolism/pathology
MH  - Neoplasm Proteins/metabolism
MH  - Neoplasms/metabolism/pathology
MH  - *Signal Transduction
MH  - TOR Serine-Threonine Kinases/*metabolism
PMC - PMC5825873
OTO - NOTNLM
OT  - Amino acids
OT  - Metabolism
OT  - Signaling
OT  - Stem cell
OT  - mTOR
COIS- Competing interestsThe authors declare no competing or financial interests.
EDAT- 2018/01/10 06:00
MHDA- 2018/03/30 06:00
PMCR- 2019/01/01
CRDT- 2018/01/10 06:00
PHST- 2018/01/10 06:00 [entrez]
PHST- 2018/01/10 06:00 [pubmed]
PHST- 2018/03/30 06:00 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 145/1/dev152595 [pii]
AID - DEV152595 [pii]
AID - 10.1242/dev.152595 [doi]
PST - epublish
SO  - Development. 2018 Jan 8;145(1):dev152595. doi: 10.1242/dev.152595.