PMID- 29311671
OWN - NLM
STAT- MEDLINE
DCOM- 20181116
LR  - 20191210
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 8
IP  - 1
DP  - 2018 Jan 8
TI  - Home Exercise Training Improves Exercise Capacity in Cirrhosis Patients: Role of 
      Exercise Adherence.
PG  - 99
LID - 10.1038/s41598-017-18320-y [doi]
LID - 99
AB  - Cirrhosis patients have reduced peak aerobic power (peak VO(2)) that is 
      associated with reduced survival. Supervised exercise training increases exercise 
      tolerance. The effect of home-based exercise training (HET) in cirrhosis is 
      unknown. The objective was to evaluate the safety and efficacy of 8 weeks of HET 
      on peak VO(2), 6-minute walk distance (6MWD), muscle mass, and quality of life in 
      cirrhosis. Random assignment to 8 weeks of HET (moderate to high intensity 
      cycling exercise, 3 days/week) or usual care. Exercise adherence defined as 
      completing >/=80% training sessions. Paired t-tests and analysis of covariance used 
      for comparisons. Forty patients enrolled: 58% male, mean age 57 y, 70% Child 
      Pugh-A. Between group increases in peak VO(2) (1.7, 95% CI: -0.33 to 
      3.7 ml/kg/min, p = 0.09) and 6MWD (33.7, 95% CI: 5.1 to 62.4 m, p = 0.02) were 
      greater after HET versus usual care. Improvements even more marked in adherent 
      subjects for peak VO(2) (2.8, 95% CI: 0.5-5.2 mL/kg/min, p = 0.02) and 6MWD 
      (46.4, 95% CI: 12.4-80.5 m, p = 0.009). No adverse events occurred during testing 
      or HET. Eight weeks of HET is a safe and effective intervention to improve 
      exercise capacity in cirrhosis, with maximal benefits occurring in those who 
      complete >/=80% of the program.
FAU - Kruger, Calvin
AU  - Kruger C
AD  - Cirrhosis Care Clinic, Department of Medicine, University of Alberta, Edmonton, 
      AB, Canada.
AD  - Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, AB, Canada.
FAU - McNeely, Margaret L
AU  - McNeely ML
AD  - Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, AB, Canada.
FAU - Bailey, Robert J
AU  - Bailey RJ
AD  - Liver Health Clinic, Royal Alexandra Hospital, Edmonton, AB, Canada.
FAU - Yavari, Milad
AU  - Yavari M
AD  - Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, AB, Canada.
FAU - Abraldes, Juan G
AU  - Abraldes JG
AUID- ORCID: 0000-0003-3421-937X
AD  - Cirrhosis Care Clinic, Department of Medicine, University of Alberta, Edmonton, 
      AB, Canada.
FAU - Carbonneau, Michelle
AU  - Carbonneau M
AD  - Cirrhosis Care Clinic, Department of Medicine, University of Alberta, Edmonton, 
      AB, Canada.
FAU - Newnham, Kim
AU  - Newnham K
AD  - Cirrhosis Care Clinic, Department of Medicine, University of Alberta, Edmonton, 
      AB, Canada.
FAU - DenHeyer, Vanessa
AU  - DenHeyer V
AD  - Cirrhosis Care Clinic, Department of Medicine, University of Alberta, Edmonton, 
      AB, Canada.
FAU - Ma, Mang
AU  - Ma M
AD  - Cirrhosis Care Clinic, Department of Medicine, University of Alberta, Edmonton, 
      AB, Canada.
FAU - Thompson, Richard
AU  - Thompson R
AD  - Department of Biomedical Engineering, University of Alberta, Edmonton, AB, 
      Canada.
FAU - Paterson, Ian
AU  - Paterson I
AD  - Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, 
      AB, Canada.
FAU - Haykowsky, Mark J
AU  - Haykowsky MJ
AD  - College of Nursing and Health Innovation, University of Texas at Arlington, 
      Arlington, Texas, USA.
FAU - Tandon, Puneeta
AU  - Tandon P
AD  - Cirrhosis Care Clinic, Department of Medicine, University of Alberta, Edmonton, 
      AB, Canada. ptandon@ualberta.ca.
AD  - Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, AB, Canada. 
      ptandon@ualberta.ca.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180108
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Adult
MH  - Comorbidity
MH  - *Exercise
MH  - Exercise Therapy/adverse effects/methods
MH  - *Exercise Tolerance
MH  - Female
MH  - Humans
MH  - Liver Cirrhosis/diagnosis/*epidemiology/therapy
MH  - Male
MH  - Middle Aged
MH  - Outcome Assessment, Health Care
MH  - Randomized Controlled Trials as Topic
MH  - Severity of Illness Index
MH  - Treatment Adherence and Compliance
PMC - PMC5758716
COIS- The authors declare that they have no competing interests.
EDAT- 2018/01/10 06:00
MHDA- 2018/11/18 06:00
PMCR- 2018/01/08
CRDT- 2018/01/10 06:00
PHST- 2017/08/25 00:00 [received]
PHST- 2017/11/28 00:00 [accepted]
PHST- 2018/01/10 06:00 [entrez]
PHST- 2018/01/10 06:00 [pubmed]
PHST- 2018/11/18 06:00 [medline]
PHST- 2018/01/08 00:00 [pmc-release]
AID - 10.1038/s41598-017-18320-y [pii]
AID - 18320 [pii]
AID - 10.1038/s41598-017-18320-y [doi]
PST - epublish
SO  - Sci Rep. 2018 Jan 8;8(1):99. doi: 10.1038/s41598-017-18320-y.