PMID- 29311778
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 11
DP  - 2017
TI  - Improved Transient Response Estimations in Predicting 40 Hz Auditory Steady-State 
      Response Using Deconvolution Methods.
PG  - 697
LID - 10.3389/fnins.2017.00697 [doi]
LID - 697
AB  - The auditory steady-state response (ASSR) is one of the main approaches in clinic 
      for health screening and frequency-specific hearing assessment. However, its 
      generation mechanism is still of much controversy. In the present study, the 
      linear superposition hypothesis for the generation of ASSRs was investigated by 
      comparing the relationships between the classical 40 Hz ASSR and three synthetic 
      ASSRs obtained from three different templates for transient auditory evoked 
      potential (AEP). These three AEPs are the traditional AEP at 5 Hz and two 40 Hz 
      AEPs derived from two deconvolution algorithms using stimulus sequences, i.e., 
      continuous loop averaging deconvolution (CLAD) and multi-rate steady-state 
      average deconvolution (MSAD). CLAD requires irregular inter-stimulus intervals 
      (ISIs) in the sequence while MSAD uses the same ISIs but evenly-spaced stimulus 
      sequences which mimics the classical 40 Hz ASSR. It has been reported that these 
      reconstructed templates show similar patterns but significant difference in 
      morphology and distinct frequency characteristics in synthetic ASSRs. The 
      prediction accuracies of ASSR using these templates show significant differences 
      (p < 0.05) in 45.95, 36.28, and 10.84% of total time points within four cycles of 
      ASSR for the traditional, CLAD, and MSAD templates, respectively, as compared 
      with the classical 40 Hz ASSR, and the ASSR synthesized from the MSAD transient 
      AEP suggests the best similarity. And such a similarity is also demonstrated at 
      individuals only in MSAD showing no statistically significant difference 
      (Hotelling's T(2) test, T(2) = 6.96, F = 0.80, p = 0.592) as compared with the 
      classical 40 Hz ASSR. The present results indicate that both stimulation rate and 
      sequencing factor (ISI variation) affect transient AEP reconstructions from 
      steady-state stimulation protocols. Furthermore, both auditory brainstem response 
      (ABR) and middle latency response (MLR) are observed in contributing to the 
      composition of ASSR but with variable weights in three templates. The 
      significantly improved prediction accuracy of ASSR achieved by MSAD strongly 
      supports the linear superposition mechanism of ASSR if an accurate template of 
      transient AEPs can be reconstructed. The capacity in obtaining both ASSR and its 
      underlying transient components accurately and simultaneously has the potential 
      to contribute significantly to diagnosis of patients with neuropsychiatric 
      disorders.
FAU - Tan, Xiaodan
AU  - Tan X
AD  - School of Biomedical Engineering, Southern Medical University, Guangzhou, China.
FAU - Fu, Qiuyang
AU  - Fu Q
AD  - Department of Otolaryngology, Guangdong Second Provincial General Hospital, 
      Guangzhou, China.
FAU - Yuan, Han
AU  - Yuan H
AD  - Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, 
      United States.
FAU - Ding, Lei
AU  - Ding L
AD  - Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, 
      United States.
FAU - Wang, Tao
AU  - Wang T
AD  - College of Big Data and Internet, Shenzhen Technology University, Shenzhen, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20171212
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC5732975
OTO - NOTNLM
OT  - auditory steady-state response
OT  - continuous loop averaging deconvolution
OT  - linear superposition hypothesis
OT  - multi-rate steady-state average deconvolution
OT  - stimulus sequencing scheme
EDAT- 2018/01/10 06:00
MHDA- 2018/01/10 06:01
PMCR- 2017/01/01
CRDT- 2018/01/10 06:00
PHST- 2017/07/26 00:00 [received]
PHST- 2017/11/27 00:00 [accepted]
PHST- 2018/01/10 06:00 [entrez]
PHST- 2018/01/10 06:00 [pubmed]
PHST- 2018/01/10 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2017.00697 [doi]
PST - epublish
SO  - Front Neurosci. 2017 Dec 12;11:697. doi: 10.3389/fnins.2017.00697. eCollection 
      2017.