PMID- 29311977 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200930 IS - 1664-042X (Print) IS - 1664-042X (Electronic) IS - 1664-042X (Linking) VI - 8 DP - 2017 TI - Links between Dietary Protein Sources, the Gut Microbiota, and Obesity. PG - 1047 LID - 10.3389/fphys.2017.01047 [doi] LID - 1047 AB - The association between the gut microbiota and obesity is well documented in both humans and in animal models. It is also demonstrated that dietary factors can change the gut microbiota composition and obesity development. However, knowledge of how diet, metabolism and gut microbiota mutually interact and modulate energy metabolism and obesity development is still limited. Epidemiological studies indicate an association between intake of certain dietary protein sources and obesity. Animal studies confirm that different protein sources vary in their ability to either prevent or induce obesity. Different sources of protein such as beans, vegetables, dairy, seafood, and meat differ in amino acid composition. Further, the type and level of other factors, such as fatty acids and persistent organic pollutants (POPs) vary between dietary protein sources. All these factors can modulate the composition of the gut microbiota and may thereby influence their obesogenic properties. This review summarizes evidence of how different protein sources affect energy efficiency, obesity development, and the gut microbiota, linking protein-dependent changes in the gut microbiota with obesity. FAU - Madsen, Lise AU - Madsen L AD - National Institute of Nutrition and Seafood Research, Bergen, Norway. AD - Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark. AD - BGI-Shenzhen, Shenzhen, China. FAU - Myrmel, Lene S AU - Myrmel LS AD - National Institute of Nutrition and Seafood Research, Bergen, Norway. FAU - Fjaere, Even AU - Fjaere E AD - National Institute of Nutrition and Seafood Research, Bergen, Norway. FAU - Liaset, Bjorn AU - Liaset B AD - National Institute of Nutrition and Seafood Research, Bergen, Norway. FAU - Kristiansen, Karsten AU - Kristiansen K AD - Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark. AD - BGI-Shenzhen, Shenzhen, China. LA - eng PT - Journal Article PT - Review DEP - 20171219 PL - Switzerland TA - Front Physiol JT - Frontiers in physiology JID - 101549006 PMC - PMC5742165 OTO - NOTNLM OT - diet OT - dietary fats OT - dietary proteins OT - gut microbiota OT - metabolism OT - mouse models OT - obesity OT - protein source EDAT- 2018/01/10 06:00 MHDA- 2018/01/10 06:01 PMCR- 2017/12/19 CRDT- 2018/01/10 06:00 PHST- 2017/09/01 00:00 [received] PHST- 2017/11/30 00:00 [accepted] PHST- 2018/01/10 06:00 [entrez] PHST- 2018/01/10 06:00 [pubmed] PHST- 2018/01/10 06:01 [medline] PHST- 2017/12/19 00:00 [pmc-release] AID - 10.3389/fphys.2017.01047 [doi] PST - epublish SO - Front Physiol. 2017 Dec 19;8:1047. doi: 10.3389/fphys.2017.01047. eCollection 2017.