PMID- 29312018
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 8
DP  - 2017
TI  - Neuroanatomical and Symptomatic Sex Differences in Individuals at Clinical High 
      Risk for Psychosis.
PG  - 291
LID - 10.3389/fpsyt.2017.00291 [doi]
LID - 291
AB  - Sex differences have been widely observed in clinical presentation, functional 
      outcome and neuroanatomy in individuals with a first-episode of psychosis, and 
      chronic patients suffering from schizophrenia. However, little is known about sex 
      differences in the high-risk stages for psychosis. The present study investigated 
      sex differences in cortical and subcortical neuroanatomy in individuals at 
      clinical high risk (CHR) for psychosis and healthy controls (CTL), and the 
      relationship between anatomy and clinical symptoms in males at CHR. Magnetic 
      resonance images were collected in 26 individuals at CHR (13 men) and 29 CTLs (15 
      men) to determine total and regional brain volumes and morphology, cortical 
      thickness, and surface area (SA). Clinical symptoms were assessed with the brief 
      psychiatric rating scale. Significant sex-by-diagnosis interactions were observed 
      with opposite directions of effect in male and female CHR subjects relative to 
      their same-sex controls in multiple cortical and subcortical areas. The right 
      postcentral, left superior parietal, inferior parietal supramarginal, and angular 
      gyri [<5% false discovery rate (FDR)] were thicker in male and thinner in female 
      CHR subjects compared with their same-sex CTLs. The same pattern was observed in 
      the right superior parietal gyrus SA at the regional and vertex level. Using a 
      recently developed surface-based morphology pipeline, we observed sex-specific 
      shape differences in the left hippocampus (<5% FDR) and amygdala (<10% FDR). 
      Negative symptom burden was significantly higher in male compared with female CHR 
      subjects (p = 0.04) and was positively associated with areal expansion of the 
      left amygdala in males (<5% FDR). Some limitations of the study include the 
      sample size, and data acquisition at 1.5 T. This study demonstrates 
      neuroanatomical sex differences in CHR subjects, which may be associated with 
      variations in symptomatology in men and women with psychotic symptoms.
FAU - Guma, Elisa
AU  - Guma E
AD  - Integrated Program in Neuroscience, Department of Psychiatry, Douglas Mental 
      Health University Institute, McGill University, Verdun, QC, Canada.
FAU - Devenyi, Gabriel A
AU  - Devenyi GA
AD  - Department of Psychiatry, Cerebral Imaging Center, Douglas Mental Health 
      University Institute, McGill University, Verdun, QC, Canada.
FAU - Malla, Ashok
AU  - Malla A
AD  - Prevention and Early Intervention Program for Psychosis, Department of 
      Psychiatry, Douglas Mental Health University Institute, McGill University, 
      Verdun, QC, Canada.
FAU - Shah, Jai
AU  - Shah J
AD  - Prevention and Early Intervention Program for Psychosis, Department of 
      Psychiatry, Douglas Mental Health University Institute, McGill University, 
      Verdun, QC, Canada.
FAU - Chakravarty, M Mallar
AU  - Chakravarty MM
AD  - Integrated Program in Neuroscience, Department of Psychiatry, Douglas Mental 
      Health University Institute, McGill University, Verdun, QC, Canada.
AD  - Department of Biological and Biomedical Engineering, Douglas Mental Health 
      University Institute, McGill University, Verdun, QC, Canada.
FAU - Pruessner, Marita
AU  - Pruessner M
AD  - Prevention and Early Intervention Program for Psychosis, Department of 
      Psychiatry, Douglas Mental Health University Institute, McGill University, 
      Verdun, QC, Canada.
AD  - Department of Psychology, University of Konstanz, Konstanz, Germany.
LA  - eng
PT  - Journal Article
DEP - 20171222
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC5744013
OTO - NOTNLM
OT  - brain morphometry
OT  - clinical high risk for psychosis
OT  - cortical thickness
OT  - sex differences
OT  - structural MRI image analysis
EDAT- 2018/01/10 06:00
MHDA- 2018/01/10 06:01
PMCR- 2017/12/22
CRDT- 2018/01/10 06:00
PHST- 2017/09/06 00:00 [received]
PHST- 2017/12/06 00:00 [accepted]
PHST- 2018/01/10 06:00 [entrez]
PHST- 2018/01/10 06:00 [pubmed]
PHST- 2018/01/10 06:01 [medline]
PHST- 2017/12/22 00:00 [pmc-release]
AID - 10.3389/fpsyt.2017.00291 [doi]
PST - epublish
SO  - Front Psychiatry. 2017 Dec 22;8:291. doi: 10.3389/fpsyt.2017.00291. eCollection 
      2017.