PMID- 29312143
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 8
DP  - 2017
TI  - Understanding Autoimmune Diabetes through the Prism of the Tri-Molecular Complex.
PG  - 351
LID - 10.3389/fendo.2017.00351 [doi]
LID - 351
AB  - The strongest susceptibility allele for Type 1 Diabetes (T1D) is human leukocyte 
      antigen (HLA), which supports a central role for T cells as the drivers of 
      autoimmunity. However, the precise mechanisms that allow thymic escape and 
      peripheral activation of beta cell antigen-specific T cells are still largely 
      unknown. Studies performed with the non-obese diabetic (NOD) mouse have 
      challenged several immunological dogmas, and have made the NOD mouse a key 
      experimental system to study the steps of immunodysregulation that lead to 
      autoimmune diabetes. The structural similarities between the NOD I-A(g7) and 
      HLA-DQ8 have revealed the stability of the T cell receptor (TCR)/HLA/peptide 
      tri-molecular complex as an important parameter in the development of autoimmune 
      T cells, as well as afforded insights into the key antigens targeted in T1D. In 
      this review, we will provide a summary of the current understanding with regard 
      to autoimmune T cell development, the significance of the antigens targeted in 
      T1D, and the relationship between TCR affinity and immune regulation.
FAU - Bettini, Matthew L
AU  - Bettini ML
AD  - Pediatric Diabetes and Endocrinology, Baylor College of Medicine, Texas 
      Children's Hospital, McNair Medical Institute, Houston, TX, United States.
FAU - Bettini, Maria
AU  - Bettini M
AD  - Pediatric Diabetes and Endocrinology, Baylor College of Medicine, Texas 
      Children's Hospital, McNair Medical Institute, Houston, TX, United States.
LA  - eng
GR  - K22 AI104761/AI/NIAID NIH HHS/United States
GR  - R01 AI125301/AI/NIAID NIH HHS/United States
GR  - R56 DK104903/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20171214
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
PMC - PMC5735072
OTO - NOTNLM
OT  - T cell
OT  - autoimmunity
OT  - human leukocyte antigen
OT  - regulatory T cell
OT  - thymic selection
OT  - type 1 diabetes
EDAT- 2018/01/10 06:00
MHDA- 2018/01/10 06:01
PMCR- 2017/01/01
CRDT- 2018/01/10 06:00
PHST- 2017/07/31 00:00 [received]
PHST- 2017/11/30 00:00 [accepted]
PHST- 2018/01/10 06:00 [entrez]
PHST- 2018/01/10 06:00 [pubmed]
PHST- 2018/01/10 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2017.00351 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2017 Dec 14;8:351. doi: 10.3389/fendo.2017.00351. 
      eCollection 2017.